{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T18:48:28Z","timestamp":1770490108368,"version":"3.49.0"},"reference-count":29,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,2,23]],"date-time":"2019-02-23T00:00:00Z","timestamp":1550880000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2019,4,15]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>The birth prevalence of orofacial clefts (OFCs) has been widely studied, but results are considerable varied, and epidemiological studies in southern China are few in numbers. To address this gap, we carried out a register\u2010based study to estimate the birth prevalence of OFCs in Bao'an district, Shenzhen, China.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data of perinatal infants born between 2003 and 2017 were extracted from Shenzhen Maternal and Child Health Management System. The overall OFCs birth prevalence with 95% confidence interval (CI) as well as subgroup analysis based on selected demographic factors was conducted. Cochran\u2013Armitage trend tests were applied to evaluate the time trend by 5\u2010year intervals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The overall birth prevalence of OFCs, cleft lip with or without cleft palate (CL\/P) and cleft palate only (CPO) was 1.30 (95% CI 1.21\u20131.39), 1.00 (95% CI 0.92\u20131.08), and 0.30 (95% CI 0.25\u20130.34) per 1,000 births, respectively. An overall declining tendency was observed in the OFCs (from 1.83 to 1.04 per 1,000 births), specifically CL\/P (from 1.53 to 0.69 per 1,000 births) birth prevalence over 5\u2010year intervals, with statistical significance (<jats:italic>p<\/jats:italic> &lt; 0.01). Subgroup analysis revealed that the CL\/P and CPO birth prevalence was differed by infant gender, household registration, maternal age, and parity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings had firstly reported the birth prevalence of OFCs in Bao'an district, and might help other researchers to plan more comprehensive public health strategies to reduce the occurrence of OFCs in further generation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.1467","type":"journal-article","created":{"date-parts":[[2019,2,26]],"date-time":"2019-02-26T04:54:02Z","timestamp":1551156842000},"page":"353-359","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Birth prevalence of orofacial clefts among perinatal infants: A register\u2010based study in Bao'an district, Shenzhen, China"],"prefix":"10.1002","volume":"111","author":[{"given":"Ya Li","family":"Luo","sequence":"first","affiliation":[{"name":"Department of Health Care Bao'an Maternal and Child Health Hospital  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Preventive Medicine Bao'an Maternal and Child Health Hospital  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao Hui","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Continuing Medical Education Health and Family Planning Capacity Building and Continuing Education Center of Shenzhen Municipality  China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue Hua","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Health Care Bao'an Maternal and Child Health Hospital  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Quan","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Health Care Bao'an Maternal and Child Health Hospital  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7710-1959","authenticated-orcid":false,"given":"Yu Li","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Health Care Bao'an Maternal and Child Health Hospital  Shenzhen China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,2,23]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1597\/03-034.1"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jom.0000214466.06076.07"},{"key":"e_1_2_6_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23133"},{"key":"e_1_2_6_5_1","first-page":"33","volume-title":"Basic demographic characteristics. 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