{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:09:57Z","timestamp":1787065797752,"version":"build-2736575974"},"reference-count":25,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T00:00:00Z","timestamp":1566345600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1 TR001085"],"award-info":[{"award-number":["UL1 TR001085"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2019,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Our goal was to develop an approach that can systematically identify potential associations between medication prescribed in pregnancy and spontaneous preterm birth (sPTB) by mining large administrative \u201cclaims\u201d databases containing hundreds of medications. One such association that we illustrate emerged with antiviral medications used for herpes treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>IBM MarketScan\u00ae databases (2007\u20132016) were used. A pregnancy cohort was established using International Classification of Diseases (ICD\u20109\/10) codes. Multiple hypothesis testing and the Benjamini\u2013Hochberg procedure that limited false discovery rate at 5% revealed, among 863 medications, five that showed odds ratios (ORs) &lt;1. The statistically strongest was an association between antivirals and sPTB that we illustrate as a real example of our approach, specifically for treatment of genital herpes (GH). Three groups of women were identified based on diagnosis of GH and treatment during the first 36\u2009weeks of pregnancy: (a) GH without treatment; (b) GH treated with antivirals; (c) no GH or treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 2,538,255 deliveries. 0.98% women had a diagnosis of GH. Among them, 60.0% received antiviral treatment. Women with treated GH had OR\u2009&lt;\u20091, (OR [95% CI] = 0.91 [0.85, 0.98]). In contrast, women with untreated GH had a small increased risk of sPTB (OR [95% CI] =1.22 [1.14, 1.32]).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Data\u2010driven approaches can effectively generate new hypotheses on associations between medications and sPTB. This analysis led us to examine the association with GH treatment. While unknown confounders may impact these findings, our results indicate that women with untreated GH have a modest increased risk of sPTB.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bdr2.1580","type":"journal-article","created":{"date-parts":[[2019,8,21]],"date-time":"2019-08-21T08:45:04Z","timestamp":1566377104000},"page":"1145-1153","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Data\u2010driven queries between medications and spontaneous preterm birth among 2.5 million pregnancies"],"prefix":"10.1002","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9441-521X","authenticated-orcid":false,"given":"Ivana","family":"Mari\u0107","sequence":"first","affiliation":[{"name":"Department of Pediatrics Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia D.","family":"Winn","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evgeniya","family":"Borisenko","sequence":"additional","affiliation":[{"name":"School of Engineering, Stanford University Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5138-7389","authenticated-orcid":false,"given":"Kari A.","family":"Weber","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald J.","family":"Wong","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natali","family":"Aziz","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yair J.","family":"Blumenfeld","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasser Y.","family":"El\u2010Sayed","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David K.","family":"Stevenson","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7438-4914","authenticated-orcid":false,"given":"Gary M.","family":"Shaw","sequence":"additional","affiliation":[{"name":"Department of Pediatrics Stanford University School of Medicine Stanford California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,8,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-015-1878-8"},{"issue":"6","key":"e_1_2_8_3_1","first-page":"1489","article-title":"Clinical management guidelines for obstetrician\u2010gynecologists. No. 82 June 2007. Management of herpes in pregnancy","volume":"109","author":"ACOG Practice Bulletin","year":"2007","journal-title":"Obstetrics and Gynecology"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23573"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semperi.2015.08.002"},{"issue":"1","key":"e_1_2_8_6_1","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate \u2010 a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini Y.","year":"1995","journal-title":"Journal of the Royal Statistical Society. Series B: Methodological"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-12943-x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.914"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1198\/016214504000000089"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3949\/ccjm.74.3.217"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(08)60074-4"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-8-25"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwu242"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3407"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3284"},{"issue":"1","key":"e_1_2_8_16_1","first-page":"1","article-title":"Births: Final data for 2016","volume":"67","author":"Martin J. A.","year":"2018","journal-title":"National Vital Statistics Reports"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.3612"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2011.02.029"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12978-017-0292-7"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1177\/0956462417727194"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.1100"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1017\/9781316275498"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpt.949"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/clpt.2011.83"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003377"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2006.07.051"}],"container-title":["Birth Defects Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdr2.1580","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.1580","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bdr2.1580","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.1580","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,22]],"date-time":"2024-07-22T06:06:58Z","timestamp":1721628418000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdr2.1580"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,8,21]]},"references-count":25,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2019,10]]}},"alternative-id":["10.1002\/bdr2.1580"],"URL":"https:\/\/doi.org\/10.1002\/bdr2.1580","archive":["Portico"],"relation":{},"ISSN":["2472-1727","2472-1727"],"issn-type":[{"value":"2472-1727","type":"print"},{"value":"2472-1727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,8,21]]},"assertion":[{"value":"2019-05-14","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-05","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-21","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}