{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T15:13:50Z","timestamp":1793805230930,"version":"4.6.1"},"reference-count":39,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T00:00:00Z","timestamp":1570060800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2019,11]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Using the National Birth Defects Prevention Network (NBDPN) annual data report, U.S. national prevalence estimates for major birth defects are developed based on birth cohort 2010\u20132014.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Data from 39\u2009U.S. population\u2010based birth defects surveillance programs (16 active case\u2010finding, 10 passive case\u2010finding with case confirmation, and 13 passive without case confirmation) were used to calculate pooled prevalence estimates for major defects by case\u2010finding approach. Fourteen active case\u2010finding programs including at least live birth and stillbirth pregnancy outcomes monitoring approximately one million births annually were used to develop national prevalence estimates, adjusted for maternal race\/ethnicity (for all conditions examined) and maternal age (trisomies and gastroschisis). These calculations used a similar methodology to the previous estimates to examine changes over time.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The adjusted national birth prevalence estimates per 10,000 live births ranged from 0.62 for interrupted aortic arch to 16.87 for clubfoot, and 19.93 for the 12 critical congenital heart defects combined. While the birth prevalence of most birth defects studied remained relatively stable over 15\u2009years, an increasing prevalence was observed for gastroschisis and Down syndrome. Additionally, the prevalence for atrioventricular septal defect, tetralogy of Fallot, omphalocele, and trisomy 18 increased in this period compared to the previous periods. Active case\u2010finding programs generally had higher prevalence rates for most defects examined, most notably for anencephaly, anophthalmia\/microphthalmia, trisomy 13, and trisomy 18.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>National estimates of birth defects prevalence provide data for monitoring trends and understanding the impact of these conditions. Increasing prevalence rates observed for selected conditions warrant further examination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bdr2.1589","type":"journal-article","created":{"date-parts":[[2019,10,3]],"date-time":"2019-10-03T08:49:56Z","timestamp":1570092596000},"page":"1420-1435","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":857,"title":["National population\u2010based estimates for major birth defects, 2010\u20132014"],"prefix":"10.1002","volume":"111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7300-0672","authenticated-orcid":false,"given":"Cara T.","family":"Mai","sequence":"first","affiliation":[{"name":"Division of Congenital and Developmental Disorders, National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer L.","family":"Isenburg","sequence":"additional","affiliation":[{"name":"Division of Congenital and Developmental Disorders, National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Canfield","sequence":"additional","affiliation":[{"name":"Birth Defects Epidemiology and Surveillance Branch Texas Department of State Health Services  Austin Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert E.","family":"Meyer","sequence":"additional","affiliation":[{"name":"North Carolina Birth Defects Monitoring Program State Center for Health Statistics  Raleigh North Carolina"},{"name":"Department of Maternal and Child Health, University of North Carolina at Chapel Hill  Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adolfo","family":"Correa","sequence":"additional","affiliation":[{"name":"University of Mississippi Medical Center  Jackson Mississippi"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clinton J.","family":"Alverson","sequence":"additional","affiliation":[{"name":"Division of Congenital and Developmental Disorders, National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0978-5863","authenticated-orcid":false,"given":"Philip J.","family":"Lupo","sequence":"additional","affiliation":[{"name":"Baylor College of Medicine  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiffany","family":"Riehle\u2010Colarusso","sequence":"additional","affiliation":[{"name":"Division of Congenital and Developmental Disorders, National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sook Ja","family":"Cho","sequence":"additional","affiliation":[{"name":"Birth Defects Monitoring &amp; Analysis Unit Minnesota Department of Health  St. Paul Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Deepa","family":"Aggarwal","sequence":"additional","affiliation":[{"name":"California Birth Defects Monitoring Program California Department of Public Health  Richmond California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3489-401X","authenticated-orcid":false,"given":"Russell S.","family":"Kirby","sequence":"additional","affiliation":[{"name":"Department of Community and Family Health, College of Public Health University of South Florida  Tampa Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"National Birth Defects Prevention Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,3]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12889-015-2223-2"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6602a1"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199911113412001"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20658"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20294"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2014.302098"},{"issue":"1","key":"e_1_2_7_8_1","first-page":"1","article-title":"Update on overall prevalence of major birth defects\u2014Atlanta, Georgia, 1978\u20132005","volume":"57","author":"Centers for Disease Control and Prevention","year":"2008","journal-title":"Morbidity and Mortality Weekly Report"},{"key":"e_1_2_7_9_1","unstructured":"Centers for Disease Control and Prevention National Vital Statistics Report. 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