{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T01:16:06Z","timestamp":1782782166019,"version":"3.54.5"},"reference-count":47,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T00:00:00Z","timestamp":1582761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["PA #96043"],"award-info":[{"award-number":["PA #96043"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["PA #02081"],"award-info":[{"award-number":["PA #02081"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["FOA #DD09\u2010001"],"award-info":[{"award-number":["FOA #DD09\u2010001"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["FOA #DD13\u2010003"],"award-info":[{"award-number":["FOA #DD13\u2010003"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["NOFO #DD18\u2010001"],"award-info":[{"award-number":["NOFO #DD18\u2010001"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Neural tube defects (NTD)s are common birth defects with a multifactorial etiology. Findings from human studies examining environmental (non\u2010inherited) exposures tend to be inconclusive. In particular, although animal studies of alcohol exposure and NTDs support its teratogenic potential, human studies are equivocal. Using data from the National Birth Defects Prevention Study (NBDPS), associations between maternal periconceptional (1\u2009month before through 1\u2009month after conception) alcohol consumption and NTDs in offspring were examined.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>NTD cases and unaffected live born singleton controls with expected dates of delivery from October 1997\u2013December 2011 were enrolled in the NBDPS. Interview reports of alcohol consumption (quantity, frequency, variability, type) from 1,922 case and 11,251 control mothers were analyzed. Crude and adjusted odds ratios (aOR)s and 95% confidence intervals (CI)s for alcohol consumption and all NTDs combined and selected subtypes (spina bifida, anencephaly, encephalocele) were estimated using unconditional logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among mothers in the NBDPS, 28% of NTD case and 35% of control mothers reported any periconceptional alcohol consumption. For each measure of alcohol consumption, inverse associations were observed for all NTDs combined (aORs = 0.6\u20131.0). Results for NTD subtypes tended to be similar, but CIs for spina bifida and encephalocele were more likely to include the null.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings suggest a lack of positive associations between maternal periconceptional alcohol consumption and NTDs. Future studies should continue to evaluate the association between maternal alcohol consumption and NTDs in offspring accounting for methodological limitations such as potential misclassification from self\u2010reported alcohol consumption.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.1656","type":"journal-article","created":{"date-parts":[[2020,2,27]],"date-time":"2020-02-27T11:24:46Z","timestamp":1582802686000},"page":"427-439","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Association between maternal periconceptional alcohol consumption and neural tube defects: Findings from the National Birth Defects Prevention Study, 1997\u20132011"],"prefix":"10.1002","volume":"112","author":[{"given":"Adia R.","family":"Louden","sequence":"first","affiliation":[{"name":"Department of Epidemiology Rollins School of Public Health, Emory University  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonathan","family":"Suhl","sequence":"additional","affiliation":[{"name":"Department of Epidemiology College of Public Health, The University of Iowa  Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2803-8030","authenticated-orcid":false,"given":"Vijaya","family":"Kancherla","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Rollins School of Public Health, Emory University  Atlanta Georgia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin M.","family":"Caspers Conway","sequence":"additional","affiliation":[{"name":"Department of Epidemiology College of Public Health, The University of Iowa  Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Makelarski","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology University of Chicago  Chicago Illinois"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8420-5040","authenticated-orcid":false,"given":"Meredith M.","family":"Howley","sequence":"additional","affiliation":[{"name":"Congenital Malformations Registry New York State Department of Health  Albany New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1605-9536","authenticated-orcid":false,"given":"Adrienne T.","family":"Hoyt","sequence":"additional","affiliation":[{"name":"Department of Health and Human Performance University of Houston  Houston Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard S.","family":"Olney","sequence":"additional","affiliation":[{"name":"Genetic Disease Screening Program California Department of Public Health  Richmond, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9115-5128","authenticated-orcid":false,"given":"Andrew F.","family":"Olshan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Gillings School of Global Public Health, University of North Carolina  Chapel Hill North Carolina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5393-9984","authenticated-orcid":false,"given":"Paul A.","family":"Romitti","sequence":"additional","affiliation":[{"name":"Department of Epidemiology College of Public Health, The University of Iowa  Iowa City Iowa"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the National Birth Defects Prevention Study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,2,27]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1432.006"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1177\/000992288402300505"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420260305"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(96)00255-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph10083263"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.13548"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199911113412006"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwr254"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwp226"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2008.06.028"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-010-1372-y"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6816a1"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddq384"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-062012-170354"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20461"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2015.10.012"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwh259"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.orcp.2016.04.005"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907328"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420460110"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dym157"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.1320440210"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-2243(92)90238-T"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.4161\/epi.4.7.9925"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23122"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.82.1.91"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1984.tb05831.x"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.c.30057"},{"key":"e_1_2_7_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1994.tb00022.x"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-012-9404-x"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.10012"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23384"},{"key":"e_1_2_7_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm146"},{"key":"e_1_2_7_35_1","volume-title":"SAS 9.4 (Version 9.4)","author":"SAS Institute Inc","year":"2013"},{"key":"e_1_2_7_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.09.039"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008894"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/81.3.669"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-007-0251-y"},{"key":"e_1_2_7_40_1","volume-title":"USDA national nutrient database for standard reference, release 16","author":"United States Department of Agriculture","year":"2004"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.2011.01682.x"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/23.6.1218"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2016.19193"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.85.7.982"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-8223(21)03057-1"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114086"},{"issue":"1","key":"e_1_2_7_47_1","first-page":"1","article-title":"Updated estimates of neural tube defects prevented by mandatory folic Acid fortification \u2010 United States, 1995\u20102011","volume":"64","author":"Williams J.","year":"2015","journal-title":"MMWR. Morbidity and Mortality Weekly Report"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182a6643c"}],"container-title":["Birth Defects Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdr2.1656","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.1656","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bdr2.1656","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.1656","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T23:44:27Z","timestamp":1694043867000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdr2.1656"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,27]]},"references-count":47,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1002\/bdr2.1656"],"URL":"https:\/\/doi.org\/10.1002\/bdr2.1656","archive":["Portico"],"relation":{},"ISSN":["2472-1727","2472-1727"],"issn-type":[{"value":"2472-1727","type":"print"},{"value":"2472-1727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,2,27]]},"assertion":[{"value":"2019-09-24","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-27","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}