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After a conservative surgery, she started with interferon alpha\u20102a to avoid recurrence. She has remained in treatment with successful results during her follow up. Considerable reduction of both maxilla and mandible lesions and bone fill have been documented. In addition, her clinical history and phenotype were suggestive of Noonan syndrome. She has short stature, broad and short neck; hypertelorism (increased distance between the eyes); downslanting palpebral fissures; sparse eyebrows and eyelashes; posteriorly rotated ears with fleshy lobes; follicular keratosis over the face, and developmental delay. Her karyotype was 46, XX. Molecular analysis of RAS\/MAPK pathway genes showed a <jats:italic>SOS1<\/jats:italic> amino acid substitution of arginine to lysine at position 552 (p.R552K). This case presents the infrequent condition of Noonan syndrome with multiple giant cell lesions (NS\/MGCL) that would be the first patient as far as we know treated with surgery and interferon alpha\u20102a for her giant cell lesions.<\/jats:p>","DOI":"10.1002\/bdr2.1659","type":"journal-article","created":{"date-parts":[[2020,2,17]],"date-time":"2020-02-17T11:42:18Z","timestamp":1581939738000},"page":"732-739","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Noonan syndrome with multiple Giant cell lesions, management and treatment with surgery and interferon alpha\u20102a therapy: Case report"],"prefix":"10.1002","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0461-7393","authenticated-orcid":false,"given":"Fernando Adri\u00e1n","family":"Rodr\u00edguez","sequence":"first","affiliation":[{"name":"Institute of Maternal and Child Research, School of Medicine University of Chile  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Loreto","family":"Castell\u00f3n","sequence":"additional","affiliation":[{"name":"Maxillofacial Unit Hospital Dr. Luis Calvo Mackenna  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Regina","family":"Moreno","sequence":"additional","affiliation":[{"name":"Unidad de Gen\u00e9tica, Gen\u00e9tica \u2013 Cl\u00ednica Alemana  Temuco Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Paez","sequence":"additional","affiliation":[{"name":"Hemato \u2013 Oncology Unit Hospital Dr. Hern\u00e1n Henr\u00edquez Aravena  Temuco Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana In\u00e9s","family":"Aracena \u00c1lvarez","sequence":"additional","affiliation":[{"name":"Unit of Genetics and Metabolic diseases, Division of Pediatrics, School of Medicine Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"},{"name":"Unit of Genetics Hospital Dr. Luis Calvo Mackenna  Santiago Chile"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,17]]},"reference":[{"key":"e_1_2_8_2_1","first-page":"1993","volume-title":"Noonan syndrome (updated 2019 Aug 8)","author":"Allanson J. 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