{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,19]],"date-time":"2025-08-19T10:48:44Z","timestamp":1755600524363,"version":"3.40.5"},"reference-count":48,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:00:00Z","timestamp":1589932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Men of reproductive age increasingly use recreational drugs. While many of these substances may reduce the quantity and quality of sperm, less is known about the effects of these exposures on their offspring. We performed a scoping review to summarize the available literature and identify areas for future research on the outcome of live\u2010born offspring of fathers who were exposed to recreational drugs before conception.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic search was conducted of the Medline, EMBASE, and Web of Science databases, which included keywords for the following substances: cannabis\u2010related products, cocaine, heroin, hallucinogens, ecstasy and amphetamines. In total, 2,983 records were screened, and 129 publications were selected for full\u2010text assessment. Publications were included if (a) the timing of exposure included the preconceptional period, and (b) if outcomes in live\u2010born offspring were compared with an unexposed group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We included 30 publications, of which 15 animal studies and 15 human studies. Animal studies showed neurocognitive abnormalities, in particular in male offspring. Interestingly, these outcomes depend significantly on the method of exposure (i.e., fixed\u2010dose administration vs. variable self\u2010administration, which mimics addiction). Human studies were limited to specific congenital malformations and childhood cancers, which showed small increased odds ratios.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>While animal studies describe impaired neurocognitive outcomes following paternal exposure to recreational drugs, data in humans is currently lacking. Human studies require sound methodology in order to confirm findings on congenital malformations and childhood cancers. In addition, future neurocognitive studies require parental neurocognitive assessments to correct for confounding effects (i.e., role of genetics).<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.1702","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T10:26:52Z","timestamp":1589970412000},"page":"970-988","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Paternal exposure to recreational drugs before conception and its effect on live\u2010born offspring: A scoping review"],"prefix":"10.1002","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6638-8405","authenticated-orcid":false,"given":"Ruud H.J.","family":"Verstegen","sequence":"first","affiliation":[{"name":"Division of Clinical Pharmacology and Toxicology, Department of Paediatrics The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guo","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology and Toxicology, Department of Paediatrics The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6780-0585","authenticated-orcid":false,"given":"Karin P.S.","family":"Langenberg\u2010Ververgaert","sequence":"additional","affiliation":[{"name":"Department of Translational Research Princess M\u00e1xima Center for Pediatric Oncology  Utrecht The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6979-4182","authenticated-orcid":false,"given":"Lily Yuxi","family":"Ren","sequence":"additional","affiliation":[{"name":"Hospital Library The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irena","family":"Nulman","sequence":"additional","affiliation":[{"name":"Division of Clinical Pharmacology and Toxicology, Department of Paediatrics The Hospital for Sick Children  Toronto Ontario Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,20]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1939-4640.1989.tb00051.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2009.08.002"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.313.7051.195"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0015-0282(16)53288-9"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890901)64:5<1169::AID-CNCR2820640534>3.0.CO;2-I"},{"issue":"20","key":"e_1_2_7_7_1","first-page":"5730","article-title":"Pre\u2010 and postconception factors associated with sporadic heritable and nonheritable retinoblastoma","volume":"49","author":"Bunin G. R.","year":"1989","journal-title":"Cancer Research"},{"key":"e_1_2_7_8_1","unstructured":"Health Canada. (2019).The 2017 Canadian Tobacco Alcohol and Drugs Survey (CTADS). Retrieved fromhttps:\/\/www.canada.ca\/en\/health\u2010canada\/services\/canadian\u2010tobacco\u2010alcohol\u2010drugs\u2010survey\/2017\u2010summary.html"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-044620-9.50034-8"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19970711)71:1<42::AID-AJMG8>3.0.CO;2-S"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12993-016-0107-y"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2017.05.054"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)66654-0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0027-5107(74)80052-7"},{"issue":"3","key":"e_1_2_7_15_1","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1007\/BF00051316","article-title":"Parents' use of cocaine and marijuana and increased risk of rhabdomyosarcoma in their children","volume":"4","author":"Grufferman S.","year":"1993","journal-title":"Cancer Causes & Control"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2005.12.003"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a113917"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1037\/adb0000542"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.k4372"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.21582"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.155.7.765"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15527"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ntt.2019.04.003"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2018.1554521"},{"issue":"3","key":"e_1_2_7_25_1","first-page":"289","article-title":"The effect of heroin addiction on human sperm parameters, histone\u2010to\u2010protamine transition, and serum sexual hormones levels","volume":"16","author":"Nazmara Z.","year":"2019","journal-title":"Urology Journal"},{"key":"e_1_2_7_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2019.05.028"},{"key":"e_1_2_7_27_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deu116"},{"key":"e_1_2_7_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000248"},{"key":"e_1_2_7_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.9.1026"},{"issue":"4","key":"e_1_2_7_30_1","first-page":"301","article-title":"Evaluation of Enkephalin\u2010degrading enzymes in sperm from heroin\u2010addicted men","volume":"13","author":"Rezaei\u2010Mojaz S.","year":"2020","journal-title":"International Journal of Fertility and Sterility"},{"key":"e_1_2_7_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19890515)63:10<1904::AID-CNCR2820631006>3.0.CO;2-W"},{"key":"e_1_2_7_32_1","doi-asserted-by":"publisher","DOI":"10.1159\/000365687"},{"key":"e_1_2_7_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a008894"},{"issue":"7","key":"e_1_2_7_34_1","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1158\/1055-9965.1230.13.7","article-title":"Parental exposure to medications and hydrocarbons and ras mutations in children with acute lymphoblastic leukemia: A report from the Children's oncology group","volume":"13","author":"Shu X. O.","year":"2004","journal-title":"Cancer Epidemiology, Biomarkers & Prevention"},{"key":"e_1_2_7_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.10017"},{"volume-title":"Key substance use and mental health indicators in the United States: Results from the 2018 National Survey on Drug Use and Health","year":"2019","author":"Substance Abuse and Mental Health Services Administration","key":"e_1_2_7_36_1"},{"key":"e_1_2_7_37_1","doi-asserted-by":"publisher","DOI":"10.7326\/M18-0850"},{"key":"e_1_2_7_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2006.00700.x"},{"key":"e_1_2_7_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3280"},{"key":"e_1_2_7_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.10859"},{"key":"e_1_2_7_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12258"},{"key":"e_1_2_7_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009666"},{"key":"e_1_2_7_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.8"},{"key":"e_1_2_7_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14310"},{"key":"e_1_2_7_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2019.02.043"},{"key":"e_1_2_7_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2018.03.012"},{"issue":"10","key":"e_1_2_7_47_1","first-page":"1036","article-title":"Distribution of tritiated cocaine in selected genital and nongenital organs following administration to male mice","volume":"116","author":"Yazigi R. A.","year":"1992","journal-title":"Archives of Pathology & Laboratory Medicine"},{"key":"e_1_2_7_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0897-1897(03)00054-5"},{"key":"e_1_2_7_49_1","first-page":"421","article-title":"Parental alcohol consumption and the risk of congenital heart diseases in offspring: An updated systematic review and meta\u2010analysis","volume":"27","author":"Zhang S.","year":"2019","journal-title":"European Journal of Preventive Cardiology"}],"container-title":["Birth Defects Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1002%2Fbdr2.1702","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.1702","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bdr2.1702","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.1702","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T15:28:52Z","timestamp":1693927732000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdr2.1702"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5,20]]},"references-count":48,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2020,8]]}},"alternative-id":["10.1002\/bdr2.1702"],"URL":"https:\/\/doi.org\/10.1002\/bdr2.1702","archive":["Portico"],"relation":{},"ISSN":["2472-1727","2472-1727"],"issn-type":[{"type":"print","value":"2472-1727"},{"type":"electronic","value":"2472-1727"}],"subject":[],"published":{"date-parts":[[2020,5,20]]},"assertion":[{"value":"2020-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-04-21","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-05-20","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}