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In the <jats:italic>LgDel<\/jats:italic> mouse model of 22q11.2 deletion syndrome (22q11DS), morphogenesis of multiple structures involved in feeding and swallowing are dysmorphic. We asked whether changes in maternal dietary Vitamin A intake can modify cranial nerve, hindbrain and pharyngeal arch artery development in the embryo as well as lung pathology that can be a sign of aspiration dysphagia in <jats:italic>LgDel<\/jats:italic> pups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Three defined amounts of vitamin A (4, 10, and 16\u2009IU\/g) were provided in the maternal diet. Cranial nerve, hindbrain and pharyngeal arch artery development was evaluated in embryos and inflammation in the lungs of pups to determine the impact of altering maternal diet on these phenotypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Reduced maternal vitamin A intake improved whereas increased intake exacerbated lung inflammation in <jats:italic>LgDel<\/jats:italic> pups. These changes were accompanied by increased incidence and\/or severity of pharyngeal arch artery and cranial nerve V (CN V) abnormalities in <jats:italic>LgDel<\/jats:italic> embryos as well as altered expression of <jats:italic>Cyp26b1<\/jats:italic> in the hindbrain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our studies demonstrate that variations in maternal vitamin A intake can influence the incidence and severity of phenotypes in a mouse model 22q11.2 deletion syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.1709","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T09:06:50Z","timestamp":1589965610000},"page":"1194-1208","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Variations in maternal vitamin A intake modifies phenotypes in a mouse model of 22q11.2 deletion 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