{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,11]],"date-time":"2026-03-11T12:44:33Z","timestamp":1773233073862,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T00:00:00Z","timestamp":1593648000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003478","name":"Ministry of Health, Labour and Welfare","doi-asserted-by":"publisher","award":["H23\u2010iyaku\u2010ippan\u2010006"],"award-info":[{"award-number":["H23\u2010iyaku\u2010ippan\u2010006"]}],"id":[{"id":"10.13039\/501100003478","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The aim of this study was to evaluate the prevalence of folic acid (FA) prescription to prenatal and postpartum women who have also been prescribed antiepileptic drugs (AED) in Japan.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The data set used in this study included women covered by health insurance between 2005 and 2016. The prevalence of FA prescriptions between 180\u2009days before pregnancy and 180\u2009days postpartum was determined from a large administrative database, with the FA prescription classified according to dose and timing.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For 33,941 women meeting our eligibility criteria, the mean maternal age at delivery was 32.3\u2009years. At least one AED was prescribed to 225 of 33,941 women between 180\u2009days before pregnancy and 180\u2009days postpartum. FA was prescribed to 32 of 225 women (14.2%) during the same period. FA was prescribed to 8.8% of women with AED within 90\u2009days before pregnancy and to 19.8% during the first trimester. FA was prescribed to 10.9% during the first 30\u2009days after conception, all of whom were prescribed FA before the pregnancy. The maximum FA dose prescribed within 90\u2009days before pregnancy was 5 mg\/day for 5 of 12 women (41.7%) and\u2009&gt;5 mg\/day for 4 of 12 women (33.3%). The maximum FA dose prescribed during the first trimester was 5 mg\/day for 14 of 22 women (63.6%) and\u2009&gt;5 mg\/day for 8 of 22 women (36.4%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The concurrent prescription of FA with AEDs in Japan was an uncommon therapeutic approach both before and during pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.1748","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T08:04:45Z","timestamp":1593677085000},"page":"1224-1233","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Folic acid prescribed to prenatal and postpartum women who are also prescribed antiepileptic drugs in Japan: Data from a health administrative database"],"prefix":"10.1002","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0901-368X","authenticated-orcid":false,"given":"Tomofumi","family":"Ishikawa","sequence":"first","affiliation":[{"name":"Laboratory of Clinical Pharmacy Tohoku University Graduate School of Pharmaceutical Sciences  Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taku","family":"Obara","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Sciences Tohoku University Hospital  Sendai Miyagi Japan"},{"name":"Tohoku Medical Megabank Organization Tohoku University  Sendai Miyagi Japan"},{"name":"Environment and Genome Research Center Tohoku University Graduate School of Medicine  Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kazutaka","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Epileptology Tohoku University Graduate School of Medicine  Sendai Miyagi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hidekazu","family":"Nishigori","sequence":"additional","affiliation":[{"name":"Fukushima Medical Center for Children and Women Fukushima Medical University  Fukushima Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Keiko","family":"Miyakoda","sequence":"additional","affiliation":[{"name":"Clinical &amp; 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