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Each of these movements are controlled by many different factors that are tightly regulated by several integral morphogenetic signaling pathways. Subject to both genetic and environmental influences, interruption at nearly any stage can disrupt lip, nasal, or palate fusion and result in a cleft. Here, we discuss many of the genetic risk factors that may contribute to the presentation of orofacial clefts in patients, and several of the key signaling pathways and underlying cellular mechanisms that control lip and palate formation, as identified primarily through investigating equivalent processes in animal models, are examined.<\/jats:p>","DOI":"10.1002\/bdr2.1754","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T07:20:11Z","timestamp":1594797611000},"page":"1588-1634","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":74,"title":["Genetics and signaling mechanisms of orofacial clefts"],"prefix":"10.1002","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3315-8157","authenticated-orcid":false,"given":"Kurt","family":"Reynolds","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine University of California Davis, School of Medicine  Sacramento California USA"},{"name":"Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children\u2010Northern California; University of California Davis, School of Medicine  Sacramento California USA"},{"name":"Biochemistry, Molecular, Cellular, and Developmental Biology (BMCDB) Graduate Group, University of California  Davis California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuwen","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine University of California Davis, School of Medicine  Sacramento California USA"},{"name":"Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children\u2010Northern California; University of California Davis, School of Medicine  Sacramento California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Medicine University of California Davis, School of Medicine  Sacramento California USA"},{"name":"Institute for Pediatric Regenerative Medicine, Shriners Hospitals for Children\u2010Northern California; 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