{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:10:38Z","timestamp":1781050238751,"version":"3.54.1"},"reference-count":51,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T00:00:00Z","timestamp":1596153600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["#5U01DD000491"],"award-info":[{"award-number":["#5U01DD000491"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Arkansas (AR) had the highest prevalence of gastroschisis in a recent study including 15 U.S. states. Our objective was to evaluate trends in prevalence and the spatiotemporal distribution of gastroschisis in AR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Infants with gastroschisis, born 1998\u20132015, were identified from the Arkansas Reproductive Health Monitoring System. Birth record data were used as denominators for calculations. Maternal residence at delivery was geocoded for spatial analyses. Annual prevalence rates (PRs) were calculated. Joinpoint regression analysis was performed to examine trends in gastroschisis and report the annual percent changes (APCs) in PRs. Spatiotemporal analyses identified counties with unusually high PRs of gastroschisis. Poisson regression, including county, year, and county*year indicators, was fit to evaluate the PRs of gastroschisis, while adjusting for county\u2010level maternal variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We identified 401 cases of gastroschisis among 694,459 live births. The overall PR of gastroschisis was 5.8\/10,000 live births. The prevalence of gastroschisis had a significant APC of +5.3% (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.0001) between 1998 and 2012, followed by a nonsignificant yearly average decrease of \u221217% through 2015 (<jats:italic>p<\/jats:italic> = 0.2). The Emerging Hot Spot Analysis and SaTScan identified an overlapping five\u2010county cluster from 2006 to 2013. Poisson regression model, including county (inside vs. outside cluster), time (before vs. after 2006), and county*time indicators, was fit to evaluate the PRs of gastroschisis. The model did not confirm the presence of a spatiotemporal cluster, once it adjusted for county\u2010level maternal characteristics (<jats:italic>p<\/jats:italic> = <jats:italic>.<\/jats:italic>549).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Close monitoring of rates of gastroschisis is warranted to determine if the PRs of gastroschisis continue to decline in AR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.1772","type":"journal-article","created":{"date-parts":[[2020,7,31]],"date-time":"2020-07-31T08:40:16Z","timestamp":1596184816000},"page":"1484-1494","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Trends in prevalence and spatiotemporal distribution of gastroschisis in Arkansas, 1998\u20132015"],"prefix":"10.1002","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0868-8420","authenticated-orcid":false,"given":"Nahed O.","family":"ELHassan","sequence":"first","affiliation":[{"name":"Department of Pediatrics (Neonatology), Arkansas Children's Hospital University of Arkansas for Medical Sciences  Little Rock Arkansas USA"},{"name":"Arkansas Center for Birth Defects Research and Prevention  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sean G.","family":"Young","sequence":"additional","affiliation":[{"name":"Arkansas Center for Birth Defects Research and Prevention  Little Rock Arkansas USA"},{"name":"Department of Environmental and Occupational Health, Fay W. Boozman College of Public Heath University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yevgeniya","family":"Gokun","sequence":"additional","affiliation":[{"name":"Arkansas Center for Birth Defects Research and Prevention  Little Rock Arkansas USA"},{"name":"Department of Biostatistics, Fay W. Boozman College of Public Heath University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fei","family":"Wan","sequence":"additional","affiliation":[{"name":"Arkansas Center for Birth Defects Research and Prevention  Little Rock Arkansas USA"},{"name":"Department of Biostatistics, Fay W. Boozman College of Public Heath University of Arkansas for Medical Sciences  Little Rock Arkansas USA"},{"name":"Division of Public Health Sciences Washington University in St. Louis  St Louis Missouri USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8318-4049","authenticated-orcid":false,"given":"Wendy N.","family":"Nembhard","sequence":"additional","affiliation":[{"name":"Arkansas Center for Birth Defects Research and Prevention  Little Rock Arkansas USA"},{"name":"Department of Epidemiology, Fay W. Boozman College of Public Heath University of Arkansas for Medical Sciences  Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-012-1196-3"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2018.1744"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000360080"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.11.052"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20642"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1000367"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-018-4308-3"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1529163"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50935-1"},{"key":"e_1_2_8_11_1","unstructured":"Center for Disease Control. 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