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The objectives of this article are to review the impact of SLE on pregnancy and current management strategies, including commonly used therapies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a review of available literature on the clinical course of SLE, diagnosis, management and pregnancy complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>SLE has a variable clinical course characterized by flares and periods of remission and can present unique challenges in the management of obstetric patients. Pregnancy in patients with SLE is associated with multiple risks, including fetal loss, preterm birth, fetal growth restriction, and hypertensive disease. With advancements in disease treatment, many women have favorable pregnancy outcomes, but appropriate preconception counseling and disease management remain important tools in reducing complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Given the implications SLE can have on women of reproductive age and in pregnancy, understanding the disease course and management is important in order to optimize pregnancy outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.1790","type":"journal-article","created":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T07:22:07Z","timestamp":1600327327000},"page":"1115-1125","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Pregnancy in systemic lupus erythematosus"],"prefix":"10.1002","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9852-8553","authenticated-orcid":false,"given":"Aleksandra","family":"Poli\u0107","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Morsani College of Medicine, University of South Florida  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah G.","family":"Obi\u010dan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Morsani College of Medicine, University of South Florida  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,9]]},"reference":[{"issue":"1","key":"e_1_2_11_2_1","doi-asserted-by":"crossref","first-page":"e44","DOI":"10.1097\/AOG.0000000000002708","article-title":"Low\u2010dose aspirin use during pregnancy","volume":"132","author":"ACOG Committee Opinion (No. 743)","year":"2018","journal-title":"Obstetrics & Gynecology"},{"issue":"2","key":"e_1_2_11_3_1","doi-asserted-by":"crossref","first-page":"e97","DOI":"10.1097\/AOG.0000000000003070","article-title":"Fetal growth restriction","volume":"133","author":"ACOG Practice Bulletin (No. 204)","year":"2019","journal-title":"Obstetrics & Gynecology"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.20999"},{"issue":"9","key":"e_1_2_11_5_1","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1002\/1529-0131(199909)42:9<1785::AID-ANR1>3.0.CO;2-#","article-title":"Guidelines for referral and management of systemic lupus erythematosus in adults","volume":"42","author":"American College of Rheumatology Ad Hoc Committee on Systemic Lupus Erythematosus Guidelines","year":"1999","journal-title":"Arthritis and Rheumatism"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2016-209770"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40930"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/acr.22791"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.13-6-580"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-200104270-00006"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.08-0761"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/MJT.0b013e3182491e02"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autrev.2009.12.008"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-014-8572-6"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006250-200306000-00031"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-142-12_Part_1-200506210-00004"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.3MR0615-272RR"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2007.05.046"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2011.11.016"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.22641"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.21663"},{"issue":"7298","key":"e_1_2_11_22_1","first-page":"1365","article-title":"Risk of miscarriage in pregnant users of NSAIDs. 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