{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T15:57:51Z","timestamp":1780502271112,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2020,9,11]],"date-time":"2020-09-11T00:00:00Z","timestamp":1599782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The enteric nervous system (ENS), a component of the peripheral nervous system in the intestinal walls, regulates motility, secretion, absorption, and blood flow. Neural crest (NC) migration, fundamental for ENS development, may be altered by central nervous system development alterations, such as neural tube defects (NTD). Intestinal innervation anomalies have been correlated to NTD. We aim to describe the ENS on a fetus with NTD and fetuses without congenital defects (FWCD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Cases<\/jats:title><jats:p>Two male and four female FWCD, 18\u201320\u2009weeks\u2010gestation (WG), and a 25 WG female anencephalic fetus. Samples from the pancreatoduodenal groove, jejunum, cecum, rectum, and appendix were analyzed by immunohistochemistry. Nervous plexuses were marked with Neuron\u2010specific enolase and S\u2010100; enteric glial cells with CD56; neuroendocrine cells with chromogranin and synaptophysin, and interstitial cells of Cajal (ICC) with CD117.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results and conclusion<\/jats:title><jats:p>The anencephalic fetus presented a rudimentary brainstem with a cerebellum. Partial frontal, temporal, and occipital bones were found. A large atrial septal defect, an enlarged kidney with a duplex collecting system and a single adrenal gland were found. NSE, S100, and CD56, showed the presence of the myenteric and submucous plexuses of the ENS; scarce interplexus reactivity may indicate inadequate development. Pancreatic and gut neuroendocrine cells, identified with chromogranin and CD56, showed that the enteroendocrine system is present. Findings on FWCD using these markers are consistent with literature descriptions. Vagal NC migration appears to be unaffected despite the presence of anencephaly, although maturation of the ENS may be altered.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.1797","type":"journal-article","created":{"date-parts":[[2020,9,24]],"date-time":"2020-09-24T17:30:37Z","timestamp":1600968637000},"page":"1720-1732","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Neural crest derivatives and neuroendocrine cells in the gut of anencephalic and fetuses without congenital defects"],"prefix":"10.1002","volume":"112","author":[{"given":"Samuel","family":"Bencomo\u2010Loeppky","sequence":"first","affiliation":[{"name":"Facultad de Medicina y Ciencias Biom\u00e9dicas Universidad Aut\u00f3noma de Chihuahua  Chihuahua Chihuahua Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Arturo","family":"Garc\u00eda\u2010Rizk","sequence":"additional","affiliation":[{"name":"Facultad de Medicina y Ciencias Biom\u00e9dicas Universidad Aut\u00f3noma de Chihuahua  Chihuahua Chihuahua Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo Alberto","family":"Cervantes\u2010Flores","sequence":"additional","affiliation":[{"name":"Facultad de Medicina y Ciencias Biom\u00e9dicas Universidad Aut\u00f3noma de Chihuahua  Chihuahua Chihuahua Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3455-9481","authenticated-orcid":false,"given":"Margarita","family":"Levario\u2010Carrillo","sequence":"additional","affiliation":[{"name":"Facultad de Medicina y Ciencias Biom\u00e9dicas Universidad Aut\u00f3noma de Chihuahua  Chihuahua Chihuahua Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ricardo","family":"Fierro Murga","sequence":"additional","affiliation":[{"name":"Facultad de Medicina y Ciencias Biom\u00e9dicas Universidad Aut\u00f3noma de Chihuahua  Chihuahua Chihuahua Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra Alicia","family":"Reza\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Facultad de Medicina y Ciencias Biom\u00e9dicas Universidad Aut\u00f3noma de Chihuahua  Chihuahua Chihuahua Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha","family":"Loya\u2010Loya","sequence":"additional","affiliation":[{"name":"Facultad de Odontolog\u00eda Universidad Aut\u00f3noma de Chihuahua  Chihuahua Chihuahua Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5918-8851","authenticated-orcid":false,"given":"Dora Virginia","family":"Ch\u00e1vez\u2010Corral","sequence":"additional","affiliation":[{"name":"Facultad de Medicina y Ciencias Biom\u00e9dicas Universidad Aut\u00f3noma de Chihuahua  Chihuahua Chihuahua Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,11]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjsrh-2018-200300"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0016-6480(82)90228-3"},{"key":"e_1_2_8_4_1","volume-title":"Embriolog\u00eda humana y biolog\u00eda del desarrollo","author":"Arteaga Mart\u00ednez S. 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