{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T19:38:08Z","timestamp":1791574688746,"version":"4.3.4"},"reference-count":34,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100012856","name":"Alberta Children's Hospital Research Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012856","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Marfan syndrome (MFS) is an autosomal dominant hereditary disorder which affects cardiovascular structure and function. With medical advances, more women with MFS experience pregnancy, which may increase maternal and neonatal risk. Existing research has been limited by small or clinical samples. This study examines the association of MFS and adverse maternal, neonatal, and obstetric outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a cross\u2010sectional study using the discharge abstract database, containing all labor and delivery hospitalizations in Canada (excluding Quebec) from fiscal years 2004\u20132015 where women delivered a live\u2010 or stillbirth. We measured maternal and neonatal morbidity, preterm births (&lt;37\u2009weeks), small\u2010for\u2010gestational\u2010age births, perinatal mortality, and adverse maternal cardiovascular events. For each outcome, we calculated the absolute risk for women with and without MFS and used generalized estimating equations with a logit function to calculate odds.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 2,682,461 women delivered a live or stillborn infant in Canada during the study period, with 135 birth events to women with MFS. Women with MFS did not have significantly higher odds of severe maternal morbidity during their delivery (aOR:1.3; 95%CI: 0.4\u20134.0). Similarly, their infants did not have significantly higher odds of neonatal morbidity. However, infants born to women with MFS were significantly more likely to be born preterm (aOR:2.6; 95%CI: 1.6\u20134.3) and to be small\u2010for\u2010gestational\u2010age (aOR:1.8; 95%CI:1.0\u20133.1).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This population\u2010based study indicates that, although some women with MFS may experience higher odds of maternal and\/or neonatal morbidity during labor and delivery, the majority of women with MFS can have healthy births with proper clinical management.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.1829","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T11:05:45Z","timestamp":1603969545000},"page":"1802-1808","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Maternal, pregnancy, and neonatal outcomes for women with Marfan syndrome"],"prefix":"10.1002","volume":"112","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5008-1457","authenticated-orcid":false,"given":"Kaylee","family":"Ramage","sequence":"first","affiliation":[{"name":"Department of Community Health Sciences University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Grabowska","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candice","family":"Silversides","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Toronto  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hude","family":"Quan","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy","family":"Metcalfe","sequence":"additional","affiliation":[{"name":"Department of Community Health Sciences University of Calgary  Calgary Alberta Canada"},{"name":"Department of Medicine University of Calgary  Calgary Alberta Canada"},{"name":"Department of Obstetrics &amp; Gynaecology University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.2312"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/AOG.0b013e3182a603bb"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.113.002105"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/heartjnl-2019-314817"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/1471-0528.12515"},{"key":"e_1_2_12_7_1","first-page":"1","volume-title":"xPharm: The comprehensive pharmacology reference","author":"De Backer J.","year":"2007"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2012.03.051"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0233697"},{"key":"e_1_2_12_10_1","first-page":"23","volume-title":"Cardiac problems in pregnancy","author":"Elkayam U.","year":"1995"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.21037\/acs.2017.10.07"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0034-1376179"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-6-64"},{"issue":"3","key":"e_1_2_12_14_1","doi-asserted-by":"crossref","first-page":"96","DOI":"10.24095\/hpcdp.29.3.01","article-title":"Validation of perinatal data in the discharge abstract database of the Canadian Institute for Health Information","volume":"29","author":"Joseph K. 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