{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:32:37Z","timestamp":1747146757817,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T00:00:00Z","timestamp":1609372800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100006952","name":"Louisiana Board of Regents","doi-asserted-by":"publisher","award":["LEQSF(2019\u201020)\u2010RD\u2010A\u201028"],"award-info":[{"award-number":["LEQSF(2019\u201020)\u2010RD\u2010A\u201028"]}],"id":[{"id":"10.13039\/100006952","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Early\u2010life immune challenges and inflammation are risk factors for a range of developmental disorders. During the course of a study examining interactions between the common antipyretic acetaminophen (APAP; paracetamol) and interleukin\u20101\u03b2 (IL\u20101\u03b2)\u2010induced inflammation in neonatal mice we observed that subcutaneous (s.c.) injection of IL\u20101\u03b2 often leads to significantly shorter, blunt\u2010tipped tails. Three times during early development, on postnatal day 5 (P5), P8, and P11, C57BL\/6J pups were given s.c. injection of either .2 \u03bcg\/kg IL\u20101\u03b2 or 5 cc\/kg injection of saline vehicle followed, after a 45\u2009min delay, by a second injection, of either 103.9 mg\/kg APAP or saline. IL\u20101\u03b2 was observed to reduce tail length\u2014via a blunting of the tail tip\u2014in treated vs. untreated mice, an effect that was significant as early as P11 and persisted through the end of the study (~P74). Interestingly, IL\u20101\u03b2\u2010induced tail blunting was significantly lessened by APAP, an interaction that may have occurred as a result of the opposing actions of APAP and IL\u20101\u03b2 on cyclooxygenase\u20102. Although this specific hypothesis and the mechanisms underlying the effects of IL\u20101\u03b2 on tail length require further study, they add to the literature suggesting that IL\u20101\u03b2 may be a critical mediator of specific adverse effects of early\u2010life inflammation.<\/jats:p>","DOI":"10.1002\/bdr2.1862","type":"journal-article","created":{"date-parts":[[2020,12,31]],"date-time":"2020-12-31T12:15:52Z","timestamp":1609416952000},"page":"382-387","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Interleukin\u20101\u03b2 injection causes loss of tail tips in neonatal mice"],"prefix":"10.1002","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1400-7356","authenticated-orcid":false,"given":"Christopher","family":"Harshaw","sequence":"first","affiliation":[{"name":"Department of Psychology University of New Orleans New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna G.","family":"Warner","sequence":"additional","affiliation":[{"name":"Department of Psychology University of New Orleans New Orleans Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,12,31]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00274.2006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1196\/annals.1296.033"},{"issue":"1","key":"e_1_2_8_4_1","first-page":"1","article-title":"Fitting linear mixed\u2010effects models using lme4","volume":"62","author":"Bates D.","year":"2015","journal-title":"Journal of Statistical Software"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2006-0116OC"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0753-3322(97)87727-X"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1460-9568.2011.07723.x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1086\/341778"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2009.08.003"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1113\/eph8702271"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000126560"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-200112000-00020"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI117187"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","unstructured":"Kuznetsova A. 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