{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T01:36:07Z","timestamp":1790386567563,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T00:00:00Z","timestamp":1616025600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004837","name":"Ministerio de Ciencia e Innovaci\u00f3n","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004837","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003243","name":"Ministerstvo Zdravotnictv\u00ed Cesk\u00e9 Republiky","doi-asserted-by":"publisher","award":["AZV 17\u201029622A"],"award-info":[{"award-number":["AZV 17\u201029622A"]}],"id":[{"id":"10.13039\/501100003243","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2021,7,15]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>Esophageal atresia (EA) affects around 2.3\u20132.6 per 10,000 births world\u2010wide. Infants born with this condition require surgical correction soon after birth. Most survival studies of infants with EA are locally or regionally based. We aimed to describe survival across multiple world regions.<\/jats:p><\/jats:sec>Methods<\/jats:title>We included infants diagnosed with EA between 1980 and 2015 from 24 birth defects surveillance programs that are members of the International Clearinghouse for Birth Defects Surveillance and Research. We calculated survival as the proportion of liveborn infants alive at 1\u2009month, 1\u2010 and 5\u2010years, among all infants with EA, those with isolated EA, those with EA and additional anomalies or EA and a chromosomal anomaly or genetic syndrome. We also investigated trends in survival over the decades, 1980s\u20132010s.<\/jats:p><\/jats:sec>Results<\/jats:title>We included 6,466 liveborn infants with EA. Survival was 89.4% (95% CI 88.1\u201390.5) at 1\u2010month, 84.5% (95% CI 83.0\u201385.9) at 1\u2010year and 82.7% (95% CI 81.2\u201384.2) at 5\u2010years. One\u2010month survival for infants with isolated EA (97.1%) was higher than for infants with additional anomalies (89.7%) or infants with chromosomal or genetic syndrome diagnoses (57.3%) with little change at 1\u2010 and 5\u2010years. Survival at 1\u2009month improved from the 1980s to the 2010s, by 6.5% for infants with isolated EA and by 21.5% for infants with EA and additional anomalies.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Almost all infants with isolated EA survived to 5\u2009years. Mortality was higher for infants with EA and an additional anomaly, including chromosomal or genetic syndromes. Survival improved from the 1980s, particularly for those with additional anomalies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.1891","type":"journal-article","created":{"date-parts":[[2021,3,18]],"date-time":"2021-03-18T12:03:08Z","timestamp":1616068988000},"page":"945-957","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Survival of infants born with esophageal atresia among 24 international birth defects surveillance programs"],"prefix":"10.1002","volume":"113","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6940-6517","authenticated-orcid":false,"given":"Jane C.","family":"Bell","sequence":"first","affiliation":[{"name":"Child Population and Translational Health Research, Children's Hospital at Westmead Clinical School University of Sydney Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth","family":"Baynam","sequence":"additional","affiliation":[{"name":"The Western Australian Register of Developmental Anomalies, Department of Health Government of Western Australia Subiaco Australia"},{"name":"School of Medicine, Division of Pediatrics; and Telethon Kids Institute University of Western Australia Perth Western Australia Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3929-3619","authenticated-orcid":false,"given":"Jorieke E. H.","family":"Bergman","sequence":"additional","affiliation":[{"name":"University of Groningen, University Medical Center Groningen Department of Genetics Groningen The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Bermejo\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"ECEMC, Research Unit on Congenital Anomalies Institute of Rare Diseases Research (IIER), Instituto de Salud Carlos III Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lorenzo D.","family":"Botto","sequence":"additional","affiliation":[{"name":"International Center on Birth Defects (ICBD) of the International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR), Division of Medical Genetics University of Utah School of Medicine Salt Lake City Utah USA"},{"name":"Division of Medical Genetics, Department of Pediatrics University of Utah School of Medicine Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark A.","family":"Canfield","sequence":"additional","affiliation":[{"name":"Birth Defects Epidemiology and Surveillance Branch Texas Department of State Health Services Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saeed","family":"Dastgiri","sequence":"additional","affiliation":[{"name":"Tabriz Health Services Management Research Center, School of Medicine Tabriz University of Medical Sciences Tabriz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miriam","family":"Gatt","sequence":"additional","affiliation":[{"name":"Malta Congenital Anomalies Registry Directorate for Health Information and Research Guardamangia Malta"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6263-2562","authenticated-orcid":false,"given":"Boris","family":"Groisman","sequence":"additional","affiliation":[{"name":"National Network of Congenital Anomalies of Argentina (RENAC), National Center of Medical Genetics National Administration of Laboratories and Health Institutes (ANLIS), National Ministry of Health Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula","family":"Hurtado\u2010Villa","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Javeriana Cali Centro M\u00e9dico Imbanaco Cali Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karin","family":"Kallen","sequence":"additional","affiliation":[{"name":"Swedish National Board of Health and Welfare and Institution of Clinical Sciences, Lund University of Lund Stockholm Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Babak","family":"Khoshnood","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Paris, Center of Research in Epidemiology and Statistics\/CRESS\/Obstetrical Perinatal and Pediatric Epidemiology Research Team (EPOP\u00e9) INSERM, INRA Paris France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Konrad","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities US Centers for Disease Control and Prevention Atlanta Georgia USA"},{"name":"National Center on Birth Defects and Developmental Disabilities Carter Consulting, Incorporated Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danielle","family":"Landau","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Soroka University Medical Center Beersheva Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge S.","family":"Lopez\u2010Camelo","sequence":"additional","affiliation":[{"name":"ECLAMC Latin American Collaborative Study of Congenital Malformations Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Martinez","sequence":"additional","affiliation":[{"name":"Registro DAN (Registro de Defectos al Nacimiento), Departamento de Gen\u00e9tica Hospital Universitario Dr. Jos\u00e9 E. Gonz\u00e1lez. Universidad Aut\u00f3noma de Nuevo Le\u00f3n Monterrey Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margery","family":"Morgan","sequence":"additional","affiliation":[{"name":"CARIS (Congenital Anomaly Register & Information Services), Public Health Wales Singleton Hospital Swansea UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4886-0045","authenticated-orcid":false,"given":"Osvaldo M.","family":"Mutchinick","sequence":"additional","affiliation":[{"name":"RYVMCE, Department of Genetics Instituto Nacional de Ciencias M\u00e9dicas y Nutrici\u00f3n Salvador Zubir\u00e1n Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4326-890X","authenticated-orcid":false,"given":"Amy E.","family":"Nance","sequence":"additional","affiliation":[{"name":"Utah Department of Health, Bureau of Children with Special Health Care Needs Utah Birth Defect Network Salt Lake City Utah USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8318-4049","authenticated-orcid":false,"given":"Wendy","family":"Nembhard","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and the Arkansas Reproductive Health Monitoring System University of Arkansas for Medical Sciences, Fay W Boozman College of Medicine Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Pierini","sequence":"additional","affiliation":[{"name":"Institute of Clinical Physiology National Research Council\/Fondazione Toscana Gabriele Monasterio Pisa Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9437-2790","authenticated-orcid":false,"given":"Anke","family":"Rissmann","sequence":"additional","affiliation":[{"name":"Malformation Monitoring Centre Saxony\u2010Anhalt Medical Faculty Otto\u2010von\u2010Guericke University Magdeburg Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyi","family":"Shan","sequence":"additional","affiliation":[{"name":"Arkansas Children's Hospital Arkansas Children's Research Institute Little Rock Arkansas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonin","family":"Sipek","sequence":"additional","affiliation":[{"name":"Department of Medical Genetics Thomayer Hospital Prague Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"Szabova","sequence":"additional","affiliation":[{"name":"Slovak Medical University in Bratislava Faculty of Public Health Bratislava Slovak Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanna","family":"Tagliabue","sequence":"additional","affiliation":[{"name":"Cancer Registry Unit Fondazione IRCCS Istituto Nazionale dei Tumori Lombardy Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lyubov S.","family":"Yevtushok","sequence":"additional","affiliation":[{"name":"OMNI\u2010Net Ukraine Birth Defects Program Rivne Ukraine"},{"name":"Rivne Regional Medical Diagnostic Center Rivne Ukraine"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ignacio","family":"Zarante","sequence":"additional","affiliation":[{"name":"Instituto de Gen\u00e9tica Humana Pontificia Universidad Javeriana Bogot\u00e1 Bogota Colombia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natasha","family":"Nassar","sequence":"additional","affiliation":[{"name":"Child Population and Translational Health Research, Children's Hospital at Westmead Clinical School University of Sydney Sydney Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,3,18]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bjs.9019"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2014.302098"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23493"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/adc.88.5.391"},{"key":"e_1_2_9_6_1","unstructured":"EUROCATMember Registries. (2020a). Retrieved fromhttps:\/\/eu-rd-platform.jrc.ec.europa.eu\/eurocat\/eurocat-members\/registries_en"},{"key":"e_1_2_9_7_1","unstructured":"EUROCATPrevalence Charts and Tables. (2020b). Retrieved fromhttps:\/\/eu\u2010rd\u2010platform.jrc.ec.europa.eu\/eurocat\/eurocat\u2010data\/prevalence_en"},{"key":"e_1_2_9_8_1","unstructured":"International Clearinghouse Birth Defects Surveillance and Research.ICBDSR Program description. Retrieved fromhttp:\/\/www.icbdsr.org\/programme-description\/"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2005.11.009"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1145"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23067"},{"key":"e_1_2_9_12_1","unstructured":"National Birth Defects Prevention Network.NBDPN State Profiles. Retrieved fromhttps:\/\/www.nbdpn.org\/state_profiles.php"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1073"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-011-3014-1"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2011-300597"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.4.777"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0890-6238(93)90085-L"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.03.075"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2005.038158"},{"key":"e_1_2_9_20_1","unstructured":"StatsDirect statistical softwarehttp:\/\/www.statsdirect.comEngland: StatsDirect Ltd(2013). Retrieved fromhttps:\/\/www.statsdirect.com\/Default.aspx"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.surg.2014.03.016"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(09)61922-X"},{"key":"e_1_2_9_23_1","unstructured":"University of Arkansas for Medical Sciences.Arkansas Reproductive Health Monitoring System.2020Retrieved fromhttps:\/\/publichealth.uams.edu\/departmentsandunits\/centers\/arkansas-center-for-excellence-in-birth-defects-research-and-prevention\/surveillance\/"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jss.2014.04.033"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.22858"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2014.12.025"}],"container-title":["Birth Defects Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.1891","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bdr2.1891","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.1891","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T12:43:04Z","timestamp":1693312984000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdr2.1891"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,3,18]]},"references-count":25,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2021,7,15]]}},"alternative-id":["10.1002\/bdr2.1891"],"URL":"https:\/\/doi.org\/10.1002\/bdr2.1891","archive":["Portico"],"relation":{},"ISSN":["2472-1727","2472-1727"],"issn-type":[{"value":"2472-1727","type":"print"},{"value":"2472-1727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,3,18]]},"assertion":[{"value":"2021-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-03-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}