{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T09:43:49Z","timestamp":1777974229508,"version":"3.51.4"},"reference-count":38,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T00:00:00Z","timestamp":1630972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Our aim was to describe the neuroimaging and clinical evaluations of children with antenatal Zika\u2010virus (ZIKV) exposure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The Colombian National Institute of Health performed serial clinical evaluations of children with probable antenatal ZIKV exposure (i.e., born to ZIKV symptomatic mothers or born with birth defects compatible with ZIKV infection, regardless of laboratory results) over 2\u2009years that included head circumference (HC), eye examination, and neurodevelopmental assessments. Clinical neuroimaging studies (head computed tomography and\/or brain magnetic resonance imaging) were analyzed for abnormalities, two\u2010dimensional measurements were made of the right and left frontal and occipital cortical thickness. Two abnormal patterns were defined: Pattern 1 (sum of four areas of cortex &lt;6\u00a0cm) and Pattern 2 (sum of four areas of cortex \u22656\u00a0cm and\u2009&lt;\u200910\u00a0cm).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Thirty\u2010one children had a neuroimaging study; in 24, cortical thickness was measured. The median age at the first visit was 8 (range: 6\u20139) months and 22 (range: 19\u201342) months at the last evaluation. In the 24 cases with cortical measurements, three were normal, 12 were in Pattern 1, and nine were in Pattern 2. Children within Pattern 1 had lower mean HC at birth and in follow\u2010up (both <jats:italic>p<\/jats:italic>\u2009&lt;\u2009.05) and a higher frequency of structural eye abnormalities (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.01). A trend towards poorer neuromotor development was seen in Pattern 1, although not statistically significant (<jats:italic>p<\/jats:italic>\u00a0=\u00a0.06).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Brain imaging classification based on cortical measurements correlate with ophthalmologic abnormalities and HC. Cortical thickness may be a marker for clinical outcomes in children with congenital ZIKV infection.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.1947","type":"journal-article","created":{"date-parts":[[2021,9,7]],"date-time":"2021-09-07T12:20:44Z","timestamp":1631017244000},"page":"1299-1312","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical and neurodevelopmental outcomes based on brain imaging studies in a Colombian cohort of children with probable antenatal Zika virus exposure"],"prefix":"10.1002","volume":"113","author":[{"given":"Marcela","family":"Daza","sequence":"first","affiliation":[{"name":"Research Division Vysnova Partners  Bethesda Maryland USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcela","family":"Mercado","sequence":"additional","affiliation":[{"name":"Division of Research in Public Health National Institute of Health of Colombia  Bogota Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4224-2692","authenticated-orcid":false,"given":"Cynthia A.","family":"Moore","sequence":"additional","affiliation":[{"name":"Division of Birth Defects and Infant Disorders National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Diana","family":"Valencia","sequence":"additional","affiliation":[{"name":"Division of Birth Defects and Infant Disorders National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Fernanda","family":"Lengua","sequence":"additional","affiliation":[{"name":"Department of Child Neurology Hospital Naval  Cartagena Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne","family":"Newton","sequence":"additional","affiliation":[{"name":"Division of Birth Defects and Infant Disorders National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Blanca","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Division of Health Sciences, School of Medicine Universidad Pedag\u00f3gica y Tecnol\u00f3gica de Colombia  Tunja Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Van T.","family":"Tong","sequence":"additional","affiliation":[{"name":"Division of Birth Defects and Infant Disorders National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro","family":"Acevedo","sequence":"additional","affiliation":[{"name":"Colombian Society of Pediatric Ophthalmology and Strabismus  Bogot\u00e1 Republic of Columbia Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Suzanne M.","family":"Gilboa","sequence":"additional","affiliation":[{"name":"Division of Birth Defects and Infant Disorders National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha L.","family":"Ospina","sequence":"additional","affiliation":[{"name":"National Institute of Health  Bogota DC Republic of Columbia Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah B.","family":"Mulkey","sequence":"additional","affiliation":[{"name":"Prenatal Pediatrics Institute Children's National Hospital  Washington District of Columbia USA"},{"name":"Department of Neurology The George Washington University School of Medicine and Health Sciences  Washington District of Columbia USA"},{"name":"Department of Pediatrics The George Washington University School of Medicine and Health Sciences  Washington District of Columbia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,9,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0883073818780105"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2017-021304"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.3174\/ajnr.A5216"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e3181b783f7"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02790-9"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1699-5"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2020.9303"},{"key":"e_1_2_11_9_1","unstructured":"Cuevas Ortiz E. 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