{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T04:40:18Z","timestamp":1721882418531},"reference-count":28,"publisher":"Wiley","issue":"3-4","license":[{"start":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T00:00:00Z","timestamp":1639612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2022,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the relationship between prepregnancy maternal body mass index (BMI) and congenital anomalies (CAs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Design<\/jats:title><jats:p>Case\u2010control study on data collected by the registry of CAs of Tuscany (Italy) and birth certificates from 2005 to 2017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main exposure<\/jats:title><jats:p>Maternal prepregnancy BMI.<\/jats:p><\/jats:sec><jats:sec><jats:title>Main outcome measures<\/jats:title><jats:p>Any major CAs and groups of organ\u2010specific anomalies. Odds ratios (ORs) were estimated using logistic regression models adjusted for maternal factors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Maternal BMI \u226525 was significantly associated with all nervous system anomalies (OR\u00a0=\u00a01.61, 95% confidence interval [95% CI] 1.13\u20132.29) and with neural tube defects (OR\u00a0=\u00a02.03, 95% CI 1.00\u20134.12); maternal underweight was significantly associated with orofacial clefts (OR\u00a0=\u00a01.67, 95% CI 1.12\u20132.48). After stratification by education, in the low education group, mothers with BMI \u226525 had an increased risk of nervous system anomalies (OR\u00a0=\u00a02.19, 95% CI 1.01\u20134.76), whereas underweight mothers had an increased risk of nervous system anomalies (OR\u00a0=\u00a03.89, 95% CI 1.44\u201310.53), orofacial clefts (OR\u00a0=\u00a02.59, 95% CI 1.24\u20135.42), and urinary anomalies (OR\u00a0=\u00a01.74, 95% CI 1.07\u20132.82). In the medium\/high education group, the only significantly increased risk was found in mothers with BMI \u226525 for nervous system anomalies (OR\u00a0=\u00a01.50, 95% CI 1.00\u20132.25).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Main results have shown a positive association of maternal BMI \u226525 with nervous system anomalies and maternal underweight with orofacial clefts. The study has also evidenced the impact of social status and provided clues to the role of maternal ethnic background.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.1970","type":"journal-article","created":{"date-parts":[[2021,12,16]],"date-time":"2021-12-16T09:36:00Z","timestamp":1639647360000},"page":"116-123","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Association between maternal body mass index and congenital anomalies: A case\u2010control study in Tuscany (Italy)"],"prefix":"10.1002","volume":"114","author":[{"given":"Lorena","family":"Mezzasalma","sequence":"first","affiliation":[{"name":"Unit of Epidemiology of Rare Diseases and Congenital Anomalies Institute of Clinical Physiology, National Council of Research  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Santoro","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology of Rare Diseases and Congenital Anomalies Institute of Clinical Physiology, National Council of Research  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alessio","family":"Coi","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology of Rare Diseases and Congenital Anomalies Institute of Clinical Physiology, National Council of Research  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"Pierini","sequence":"additional","affiliation":[{"name":"Unit of Epidemiology of Rare Diseases and Congenital Anomalies Institute of Clinical Physiology, National Council of Research  Pisa Italy"},{"name":"Fondazione Toscana Gabriele Monasterio  Pisa Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,16]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ede.0000147122.97061.bb"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12687-018-0387-z"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12084"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1597\/04-012.1"},{"key":"e_1_2_9_6_1","unstructured":"EUROCAT(2021a).European network of population\u2010based registries for the epidemiological surveillance of congenital anomalies. 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