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Our objectives were to estimate the prevalence of these disorders among individuals with CHDs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Using IBM\u00ae MarketScan\u00ae Databases, we identified adults age 18\u201349\u2009years with \u22652 outpatient anxiety\/depressive disorder claims on separate dates or \u22651 inpatient anxiety\/depressive disorder claim in 2017. CHDs were defined as \u22652 outpatient CHD claims \u226530\u2009days apart or \u22651 inpatient CHD claim documented in 2007\u20132017. We used log\u2010binomial regression to estimate adjusted prevalence ratios (aPR) and 95% confidence intervals (CI) for associations between CHDs and anxiety\/depressive disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 13,807 adults with CHDs, 12.4% were diagnosed with an anxiety or depressive disorder. Adults with CHDs, compared to the 5,408,094 without CHDs, had higher prevalence of PTSD (0.8% vs. 0.5%; aPR: 1.5 [CI: 1.2\u20131.8]), anxiety disorders (9.9% vs. 7.5%; aPR: 1.3 [CI: 1.3\u20131.4]), and depressive disorders (6.3% vs. 4.9%; aPR: 1.3 [CI: 1.2\u20131.4]). Among individuals with CHDs, female sex (aPR range: 1.6\u20133.3) and inpatient admission (aPR range 1.1\u20131.9) were associated with anxiety\/depressive disorders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Over 1 in 8 adults with CHDs had diagnosed PTSD and\/or other anxiety\/depressive disorders, 30\u201350% higher than adults without CHDs. PTSD was rare, but three times more common in women with CHDs than men. Screening and referral for services for these conditions in people with CHDs may be beneficial.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.1971","type":"journal-article","created":{"date-parts":[[2021,12,22]],"date-time":"2021-12-22T05:39:22Z","timestamp":1640151562000},"page":"124-135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Post\u2010traumatic stress disorder, anxiety, and depression among adults with congenital heart defects"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2779-3747","authenticated-orcid":false,"given":"Regina M.","family":"Simeone","sequence":"first","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3063-1781","authenticated-orcid":false,"given":"Karrie F.","family":"Downing","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5674-3079","authenticated-orcid":false,"given":"William V.","family":"Bobo","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Mayo Clinic  Jacksonville Florida USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1078-6855","authenticated-orcid":false,"given":"Scott D.","family":"Grosse","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3514-9134","authenticated-orcid":false,"given":"Amber D.","family":"Khanna","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Division of Cardiology, School of Medicine University of Colorado Anschutz Medical Campus  Aurora Colorado USA"},{"name":"Department of Pediatrics, Division of Cardiology, School of Medicine University of Colorado Anschutz Medical Campus  Aurora Colorado USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9773-9009","authenticated-orcid":false,"given":"Sherry L.","family":"Farr","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,12,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.013450"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0277-9536(99)00399-8"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.books.9780890425596"},{"key":"e_1_2_8_5_1","unstructured":"American Psychiatric Association. 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