{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T15:43:13Z","timestamp":1757778193866,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,12,23]],"date-time":"2021-12-23T00:00:00Z","timestamp":1640217600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA24986701"],"award-info":[{"award-number":["R01CA24986701"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2022,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Individuals with Down syndrome (DS) have a higher prevalence of additional congenital anomalies, especially cardiovascular defects, compared to the general population. Several reports have indicated that the prevalence of DS among live births varies by race and ethnicity within the United States. We aim to examine variations in co\u2010occurring congenital anomalies by maternal race\/ethnicity among infants and fetuses diagnosed with DS born during 2013\u20132017.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>State birth defect surveillance systems (<jats:italic>N<\/jats:italic>\u00a0=\u200912) submitted data on infants and fetuses diagnosed with DS born during 2013\u20132017. We calculated the prevalence of co\u2010occurring major and minor congenital anomalies, by organ system, and four selected cardiovascular birth defects, all stratified by maternal race\/ethnicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 5,836 cases of DS, 79.7% had one or more co\u2010occurring congenital anomalies. There was a higher percentage of co\u2010occurring congenital anomalies among infants and fetuses born to Hispanic mothers. The lowest percentage of co\u2010occurring congenital anomalies, including three out of the four individual cardiovascular conditions examined, was among infants\/fetuses born to non\u2010Hispanic American Indian\/Alaska Native mothers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We describe differences in DS co\u2010occurrence with additional congenital anomalies among maternal racial\/ethnic groups. These data may help focus future research on differences among racial\/ethnic groups in the diagnosis and reporting of co\u2010occurring congenital anomalies in infants\/fetuses diagnosed with DS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.1975","type":"journal-article","created":{"date-parts":[[2021,12,24]],"date-time":"2021-12-24T05:53:42Z","timestamp":1640325222000},"page":"57-61","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Co\u2010occurrence of congenital anomalies by maternal race\/ethnicity among infants and fetuses with Down syndrome, 2013\u20132017: A U.S. population\u2010based analysis"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0461-1410","authenticated-orcid":false,"given":"Erin B.","family":"Stallings","sequence":"first","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer L.","family":"Isenburg","sequence":"additional","affiliation":[{"name":"National Center on Birth Defects and Developmental Disabilities Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9217-3723","authenticated-orcid":false,"given":"Dominique","family":"Heinke","sequence":"additional","affiliation":[{"name":"Massachusetts Department of Public Health Center for Birth Defects Research and Prevention  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie L.","family":"Sherman","sequence":"additional","affiliation":[{"name":"Department of Human Genetics Emory School of Medicine  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3489-401X","authenticated-orcid":false,"given":"Russell S.","family":"Kirby","sequence":"additional","affiliation":[{"name":"College of Public Health University of South Florida  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0978-5863","authenticated-orcid":false,"given":"Philip J.","family":"Lupo","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Section of Hematology\u2010Oncology Baylor College of Medicine  Houston Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"name":"for the National Birth Defects Prevention Network","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,12,23]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1002\/bdra.23341"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.1056\/NEJMra1706537"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.2105\/ajph.2014.302098"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.1038\/s41416-020-1019-z"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_1","DOI":"10.1016\/0010-4825(92)90023-G"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_1","DOI":"10.1002\/ajmg.a.37001"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_1","DOI":"10.2105\/AJPH.2013.301339"},{"doi-asserted-by":"publisher","key":"e_1_2_10_9_1","DOI":"10.1097\/GIM.0b013e3181634867"},{"doi-asserted-by":"publisher","key":"e_1_2_10_10_1","DOI":"10.1002\/bdr2.1854"},{"doi-asserted-by":"publisher","key":"e_1_2_10_11_1","DOI":"10.1002\/bdr2.1589"},{"unstructured":"National Birth Defect Prevention Network. (2017).Guidelines for Conducting Birth Defects Surveillance. Birth Defects Descriptions for NBDPN Core Recommended and Extended Conditions. Retrieved fromhttps:\/\/www.nbdpn.org\/guidelines.php","key":"e_1_2_10_12_1"},{"doi-asserted-by":"publisher","key":"e_1_2_10_13_1","DOI":"10.1002\/bdr2.1607"},{"key":"e_1_2_10_14_1","first-page":"1","article-title":"Key facts about the uninsured population","author":"Tolbert J.","year":"2019","journal-title":"Kaiser Family Foundation"}],"container-title":["Birth Defects Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.1975","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bdr2.1975","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.1975","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T08:16:29Z","timestamp":1693210589000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdr2.1975"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,23]]},"references-count":13,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,1,15]]}},"alternative-id":["10.1002\/bdr2.1975"],"URL":"https:\/\/doi.org\/10.1002\/bdr2.1975","archive":["Portico"],"relation":{},"ISSN":["2472-1727","2472-1727"],"issn-type":[{"type":"print","value":"2472-1727"},{"type":"electronic","value":"2472-1727"}],"subject":[],"published":{"date-parts":[[2021,12,23]]},"assertion":[{"value":"2021-09-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-12-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}