{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,4]],"date-time":"2026-11-04T20:04:43Z","timestamp":1793822683848,"version":"4.6.1"},"reference-count":34,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T00:00:00Z","timestamp":1655251200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2022,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>In this study, we present our long\u2010term treatment outcomes of bladder augmentation (BA), bladder neck closure, and Mitrofanoff clean intermittent catheterization (CIC) in managing bladder exstrophy (BE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a retrospective medical records' review of 33 children diagnosed as born with BE, followed up at a tertiary pediatric urology clinic from 1988 to 2020. Outcomes such as surgical interventions, presence of renal calculi, hydronephrosis, and continence status were extracted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median follow\u2010up of the group was 18.2 (4\u201326) years. Urinary system stones developed in 10 (30.3%) cases about 8.9\u2009years after BA. Stone development was two times more common in patients who underwent colocystoplasty (33.3%) than those who underwent ileocytoplasty (16.6%). The state of continence of the group was satisfactory in 26 (78.7%; excellent in 23; good in 3 cases) and unsatisfactory (wet) in 6 (18.1%) cases. At the last visit, ultrasonography revealed no hydronephrosis in 23 (69.6%) patients, and the voiding cystourethrogram demonstrated low\u2010grade vesicoureteral reflux in 10 (30.3%) and high\u2010grade vesicoureteral reflux in 2 (6%) patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>An elaborated plan of surgical reconstruction for classic BE can lead to satisfactory long\u2010term urinary continence in most patients. Ultimate predictors of outcome in BE repair are difficult to ascertain. Consistently, BA, bladder neck closure, and Mitrofanoff CIC continue to stand out at a critical point in the management of those patients with classic BE. Our study demonstrated that augmentation is required to achieve acceptable dryness with high satisfactory dryness rates in BE.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2056","type":"journal-article","created":{"date-parts":[[2022,6,15]],"date-time":"2022-06-15T09:13:58Z","timestamp":1655284438000},"page":"645-651","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Bladder augmentation in exstrophy vesicae: Long\u2010term results of a single experienced center"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8930-6692","authenticated-orcid":false,"given":"Hasan","family":"Demirkan","sequence":"first","affiliation":[{"name":"Department of Pediatric Urology Kanuni Sultan S\u00fcleyman Training and Research Hospital\/Health Sciences University  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0375-9760","authenticated-orcid":false,"given":"Mehmet \u00d6zg\u00fcr","family":"Kuzdan","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery Ba\u015fak\u015fehir \u00c7am and Sakura City Hospital\/Health Sciences University  \u0130stanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,6,15]]},"reference":[{"key":"e_1_2_13_2_1","volume-title":"Bladder Exstrophy","author":"Anand S.","year":"2021"},{"key":"e_1_2_13_3_1","volume-title":"Epispadias","author":"Anand S.","year":"2021"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2006.09.009"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2016.07.018"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2007.09.006"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1053\/ajkd.2002.34487"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2013.11.031"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.sla.0000133083.54934.ae"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1172-4-23"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000027525.81696.02"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0022-5347(17)36742-3"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1464-410x.2003.04000.x"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000139190.77295.cb"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1464-410x.1991.tb15402.x"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncpuro0407"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.juro.2011.07.022"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf02388714"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpurol.2007.07.009"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/ju.0000000000000505"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2004.07.029"},{"key":"e_1_2_13_22_1","volume-title":"Campbell\u2010Walsh urology","author":"Mathews R. 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