{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T23:01:15Z","timestamp":1791846075422,"version":"4.3.4"},"reference-count":80,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2022,7,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gestation alcohol consumption produces fetal growth restriction and malformations by affecting the embryo\u2013fetal development. Recently a relationship between abnormal placentation and fetal malformation and intrauterine growth retardation has been suggested. However, the effects of perigestational alcohol ingestion up to early pregnancy on the placenta at term and its association with fetal abnormalities are little known.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In female mice, ethanol 10% in water was administered for 15\u2009days previous and up to days 4 (D4), 8 (D8), or 10 (D10) of gestation (TF), and gestation continues without ethanol exposure. Control females (CF) received ethanol\u2010free water. At day 18, feto\u2010placental units and implantation sites were studied.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>TF had increased resorptions and only fetuses from D8\u2010TF and D10\u2010TF had significantly increased weights versus CF. D4 and D10\u2010TF\u2010placentas had significantly reduced weights. All TF had increased junctional zone (JZ) and reduced labyrinth (Lab) areas (PAS\u2010histology and morphometry) compared with CF. Fetuses with mainly with craniofacial abnormalities and skeletal defects (Alizarin red staining), significantly increase; while the fetal bone density (alizarin color intensity, <jats:italic>ImageJ<\/jats:italic>) was reduced in D4, D8 and D10\u2010TF versus CF. Although all TF\u2010placentas were histo\u2010structural affected, TF\u2010abnormal fetuses had the most severe placental anomalies, with junctional abundant glycogenic cells into the labyrinth, disorganized labyrinthine vascularization with signs of leukocyte infiltrates and feto\u2010maternal blood mix.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Perigestational alcohol consumption up to early gestation induces at term fetal growth alterations, dysmorphology and defective skeleton, linked to deficient growth and abnormal morphogenesis of placenta, highlighting insight into the prenatal etiology of FASD.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2063","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T10:34:05Z","timestamp":1656671645000},"page":"611-630","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Abnormal growth and morphogenesis of placenta at term is linked to adverse fetal development after perigestational alcohol consumption up to early gestation in mouse"],"prefix":"10.1002","volume":"114","author":[{"given":"Gisela Soledad","family":"Gualdoni","sequence":"first","affiliation":[{"name":"Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires  Buenos Aires Argentina"},{"name":"Instituto de Biodiversidad y Biolog\u00eda Experimental y Aplicada (IBBEA) CONICET\u2010Universidad de Buenos Aires  Buenos Aires Argentina"},{"name":"Departamento de Biodiversidad y Biolog\u00eda Experimental (DBBE) Universidad de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leticia","family":"P\u00e9rez\u2010Tito","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camila","family":"Barril","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires  Buenos Aires Argentina"},{"name":"Instituto de Biodiversidad y Biolog\u00eda Experimental y Aplicada (IBBEA) CONICET\u2010Universidad de Buenos Aires  Buenos Aires Argentina"},{"name":"Departamento de Biodiversidad y Biolog\u00eda Experimental (DBBE) Universidad de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristian","family":"Sobarzo","sequence":"additional","affiliation":[{"name":"Facultad de Medicina, CONICET Universidad de Buenos Aires, Instituto de Investigaciones Biom\u00e9dicas (INBIOMED)  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisa","family":"Cebral","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Exactas y Naturales Universidad de Buenos Aires  Buenos Aires Argentina"},{"name":"Instituto de Biodiversidad y Biolog\u00eda Experimental y Aplicada (IBBEA) CONICET\u2010Universidad de Buenos Aires  Buenos Aires Argentina"},{"name":"Departamento de Biodiversidad y Biolog\u00eda Experimental (DBBE) Universidad de Buenos Aires  Buenos Aires Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,7]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/0892-0362(95)00005-C"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/0892-0362(95)98055-6"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(05)00014-6"},{"issue":"2","key":"e_1_2_9_5_1","first-page":"358","article-title":"Interactions between trophoblast cells and the maternal and fetal circulation in the mouse placenta","volume":"250","author":"Adamson S. 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