{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,27]],"date-time":"2025-12-27T21:04:45Z","timestamp":1766869485448,"version":"3.40.5"},"reference-count":67,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Prenatal CNS disruptions can be associated with physically separate findings. Examples include cognitive issues in septo\u2010optic dysplasia and sporadic and <jats:italic>WNT1<\/jats:italic>\u2010related unilateral cerebellar hypoplasia, and physical findings such as thinning of the corpus callosum, ventriculomegaly, hippocampal abnormalities, olfactory tract and bulb hypoplasia, and distant cortical dysplasias with schizencephaly. Similar effects to toxicities with intraventricular hemorrhage in prematurity could occur earlier in development. CSF transportation of disruption by\u2010products would provide access to vulnerable areas through inflammatory effects on blood\u2013brain barrier permeability. Outcomes are influenced by location and volume of byproducts in the CSF, timing, transport, and inflammatory responses. A particular association of vermis disruption with cognitive issues may be related to CSF flow distortions that avoid toxin dilutions in the third ventricle. Symmetrical contralateral cortical dysplasia with schizencephaly may reflect immunovascular field\u2010related vulnerabilities seen in situations such as vitiligo.<\/jats:p>","DOI":"10.1002\/bdr2.2064","type":"journal-article","created":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T10:59:40Z","timestamp":1656673180000},"page":"847-854","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hypothesis: <scp>By\u2010products<\/scp> of vascular disruption carried in the <scp>CSF<\/scp> affect prenatal brain development"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6788-6876","authenticated-orcid":false,"given":"Mark","family":"Lubinsky","sequence":"first","affiliation":[{"name":"Wauwatosa Wisconsin USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1023\/A:1007074420772"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.1136\/jmedgenet-2015-103476"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.1148\/radiology.171.1.2928524"},{"issue":"1","key":"e_1_2_10_5_1","first-page":"85","article-title":"Schizencephaly: Correlation of clinical findings with MR characteristics","volume":"13","author":"Barkovich A. J.","year":"1992","journal-title":"American Journal of Neuroradiology"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_1","DOI":"10.1007\/s12311-010-0225-2"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_1","DOI":"10.1210\/jc.2003-030527"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_1","DOI":"10.3174\/ajnr.A4738"},{"doi-asserted-by":"publisher","key":"e_1_2_10_9_1","DOI":"10.1016\/j.siny.2016.04.014"},{"doi-asserted-by":"publisher","key":"e_1_2_10_10_1","DOI":"10.1093\/jnen\/nly058"},{"doi-asserted-by":"publisher","key":"e_1_2_10_11_1","DOI":"10.1111\/jnc.13720"},{"doi-asserted-by":"publisher","key":"e_1_2_10_12_1","DOI":"10.1002\/ajmg.a.30862"},{"doi-asserted-by":"publisher","key":"e_1_2_10_13_1","DOI":"10.1073\/pnas.0805165106"},{"doi-asserted-by":"publisher","key":"e_1_2_10_14_1","DOI":"10.1038\/ncomms2230"},{"doi-asserted-by":"publisher","key":"e_1_2_10_15_1","DOI":"10.1136\/jmedgenet-2013-101750"},{"doi-asserted-by":"publisher","key":"e_1_2_10_16_1","DOI":"10.1542\/peds.2007-1825"},{"doi-asserted-by":"publisher","key":"e_1_2_10_17_1","DOI":"10.1016\/j.brainres.2015.12.060"},{"doi-asserted-by":"publisher","key":"e_1_2_10_18_1","DOI":"10.1007\/s12975-016-0480-8"},{"doi-asserted-by":"publisher","key":"e_1_2_10_19_1","DOI":"10.3389\/fnana.2017.00064"},{"doi-asserted-by":"publisher","key":"e_1_2_10_20_1","DOI":"10.1080\/08977190701272933"},{"doi-asserted-by":"publisher","key":"e_1_2_10_21_1","DOI":"10.1186\/s12974-014-0200-9"},{"doi-asserted-by":"publisher","key":"e_1_2_10_22_1","DOI":"10.1186\/1742-2094-10-100"},{"doi-asserted-by":"publisher","key":"e_1_2_10_23_1","DOI":"10.1177\/028418519303400403"},{"doi-asserted-by":"publisher","key":"e_1_2_10_24_1","DOI":"10.1007\/s00234-018-2056-7"},{"doi-asserted-by":"publisher","key":"e_1_2_10_25_1","DOI":"10.1177\/10935266221080134"},{"doi-asserted-by":"publisher","key":"e_1_2_10_26_1","DOI":"10.1038\/nrneurol.2015.13"},{"doi-asserted-by":"publisher","key":"e_1_2_10_27_1","DOI":"10.1002\/ajmg.a.36395"},{"doi-asserted-by":"publisher","key":"e_1_2_10_28_1","DOI":"10.1007\/s00234-001-0719-1"},{"doi-asserted-by":"publisher","key":"e_1_2_10_29_1","DOI":"10.1177\/0271678X16630991"},{"doi-asserted-by":"publisher","key":"e_1_2_10_30_1","DOI":"10.1002\/bdr2.1160"},{"issue":"75","key":"e_1_2_10_31_1","first-page":"2012","article-title":"Schizencephaly prevalence, prenatal diagnosis and clues to etiology: A register\u2010based study","volume":"39","author":"Howe D. T.","year":"2012","journal-title":"Ultrasound in Obstetrics & Gynecology"},{"doi-asserted-by":"publisher","key":"e_1_2_10_32_1","DOI":"10.1016\/j.brainres.2018.08.009"},{"doi-asserted-by":"publisher","key":"e_1_2_10_33_1","DOI":"10.1007\/s00381-017-3480-4"},{"doi-asserted-by":"publisher","key":"e_1_2_10_34_1","DOI":"10.1038\/s10038-019-0565-9"},{"doi-asserted-by":"publisher","key":"e_1_2_10_35_1","DOI":"10.1093\/pch\/pxx118"},{"doi-asserted-by":"publisher","key":"e_1_2_10_36_1","DOI":"10.4103\/bc.BC_3_18"},{"doi-asserted-by":"publisher","key":"e_1_2_10_37_1","DOI":"10.4324\/9781315692289-3"},{"doi-asserted-by":"publisher","key":"e_1_2_10_38_1","DOI":"10.1186\/s12881-018-0639-0"},{"doi-asserted-by":"publisher","key":"e_1_2_10_39_1","DOI":"10.1111\/j.1750-3639.2009.00293.x"},{"doi-asserted-by":"publisher","key":"e_1_2_10_40_1","DOI":"10.1542\/peds.2007-1041"},{"doi-asserted-by":"publisher","key":"e_1_2_10_41_1","DOI":"10.1002\/(SICI)1096-8628(19970331)69:3<235::AID-AJMG4>3.0.CO;2-K"},{"doi-asserted-by":"publisher","key":"e_1_2_10_42_1","DOI":"10.1002\/(SICI)1096-8628(19970331)69:3<235::AID-AJMG4>3.0.CO;2-K"},{"doi-asserted-by":"publisher","key":"e_1_2_10_43_1","DOI":"10.1002\/ajmg.a.31303"},{"doi-asserted-by":"publisher","key":"e_1_2_10_44_1","DOI":"10.1016\/j.neuroscience.2017.03.026"},{"doi-asserted-by":"publisher","key":"e_1_2_10_45_1","DOI":"10.1016\/j.molmed.2012.12.001"},{"doi-asserted-by":"publisher","key":"e_1_2_10_46_1","DOI":"10.1002\/uog.13217"},{"doi-asserted-by":"publisher","key":"e_1_2_10_47_1","DOI":"10.1093\/jnen\/nlx017"},{"doi-asserted-by":"publisher","key":"e_1_2_10_48_1","DOI":"10.1016\/j.jped.2020.10.006"},{"doi-asserted-by":"publisher","key":"e_1_2_10_49_1","DOI":"10.1016\/j.pneurobio.2017.01.002"},{"doi-asserted-by":"publisher","key":"e_1_2_10_50_1","DOI":"10.3174\/ajnr.A3872"},{"doi-asserted-by":"publisher","key":"e_1_2_10_51_1","DOI":"10.1016\/j.nic.2016.03.006"},{"doi-asserted-by":"publisher","key":"e_1_2_10_52_1","DOI":"10.1055\/s-0030-1248265"},{"doi-asserted-by":"publisher","key":"e_1_2_10_53_1","DOI":"10.1007\/s003810000389"},{"doi-asserted-by":"publisher","key":"e_1_2_10_54_1","DOI":"10.1007\/s00431-007-0666-x"},{"doi-asserted-by":"publisher","key":"e_1_2_10_55_1","DOI":"10.1093\/brain\/awx191"},{"doi-asserted-by":"publisher","key":"e_1_2_10_56_1","DOI":"10.1016\/B978-0-12-809405-1.00020-1"},{"doi-asserted-by":"publisher","key":"e_1_2_10_57_1","DOI":"10.1016\/j.ejpn.2003.12.005"},{"doi-asserted-by":"publisher","key":"e_1_2_10_58_1","DOI":"10.1016\/j.spen.2017.08.010"},{"issue":"2","key":"e_1_2_10_59_1","first-page":"389","article-title":"MR evaluation of the hippocampus in patients with congenital malformations of the brain","volume":"22","author":"Sato N.","year":"2001","journal-title":"American Journal of Neuroradiology"},{"doi-asserted-by":"publisher","key":"e_1_2_10_60_1","DOI":"10.3174\/ajnr.A3959"},{"doi-asserted-by":"publisher","key":"e_1_2_10_61_1","DOI":"10.1155\/2018\/7692182"},{"doi-asserted-by":"publisher","key":"e_1_2_10_62_1","DOI":"10.1186\/s40478-014-0080-3"},{"key":"e_1_2_10_63_1","first-page":"P2","article-title":"Optic nerve hypoplasia in patients with septo optic dysplasia (SOD) and isolated optic nerve hypoplasia (ONH)","volume":"17","author":"Stone E.","year":"2008","journal-title":"Endocrine Abstracts"},{"doi-asserted-by":"publisher","key":"e_1_2_10_64_1","DOI":"10.1227\/NEU.0000000000000524"},{"doi-asserted-by":"publisher","key":"e_1_2_10_65_1","DOI":"10.1002\/cnm.3532"},{"doi-asserted-by":"publisher","key":"e_1_2_10_66_1","DOI":"10.1067\/mpd.2002.121822"},{"doi-asserted-by":"publisher","key":"e_1_2_10_67_1","DOI":"10.1002\/ana.23736"},{"doi-asserted-by":"publisher","key":"e_1_2_10_68_1","DOI":"10.1007\/s12975-015-0428-4"}],"container-title":["Birth Defects Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.2064","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bdr2.2064","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.2064","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T20:39:05Z","timestamp":1692736745000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdr2.2064"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":67,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1002\/bdr2.2064"],"URL":"https:\/\/doi.org\/10.1002\/bdr2.2064","archive":["Portico"],"relation":{},"ISSN":["2472-1727","2472-1727"],"issn-type":[{"type":"print","value":"2472-1727"},{"type":"electronic","value":"2472-1727"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"2022-04-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}