{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:33:00Z","timestamp":1747146780931,"version":"3.40.5"},"reference-count":10,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T00:00:00Z","timestamp":1659139200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2022,8,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>During the Centers for Disease Control and Prevention's Zika Virus Response, birth defects surveillance programs adapted to monitor birth defects potentially related to Zika virus (ZIKV) infection during pregnancy. Pregnancy outcomes occurring during January 2016 to June 2017 in 22\u2009U.S. states and territories were used to estimate the prevalence of those brain and eye defects potentially related to ZIKV. Jurisdictions were divided into three groups: areas with widespread ZIKV transmission, areas with limited local ZIKV transmission, and areas without local ZIKV transmission. Prevalence estimates for selected brain and eye defects and microcephaly per 10,000 live births were estimated. Prevalence ratios (PRs) and 95% confidence intervals (CIs) were estimated using Poisson regression for areas with widespread and limited ZIKV transmission compared with areas without local ZIKV transmission. Defects with significantly higher prevalence in areas of widespread transmission were pooled, and PRs were calculated by quarter, comparing subsequent quarters to the first quarter (January\u2013March 2016). Nine defects had significantly higher prevalence in areas of widespread transmission. The highest PRs were seen in intracranial calcifications (PR\u00a0=\u00a012.6, 95% CI [7.4, 21.3]), chorioretinal abnormalities (12.5 [7.1, 22.3]), brainstem abnormalities (9.3 [4.7, 18.4]), and cerebral\/cortical atrophy (6.7 [4.2, 10.8]). The PR of the nine pooled defects was significantly higher in three quarters in areas with widespread transmission. The largest difference in prevalence was observed for defects consistently reported in infants with congenital ZIKV infection. Birth defects surveillance programs could consider monitoring a subset of birth defects potentially related to ZIKV in pregnancy.<\/jats:p>","DOI":"10.1002\/bdr2.2067","type":"journal-article","created":{"date-parts":[[2022,7,30]],"date-time":"2022-07-30T20:52:46Z","timestamp":1659214366000},"page":"805-811","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Prevalence of individual brain and eye defects potentially related to Zika virus in pregnancy in 22\u2009U.S. states and territories, January 2016 to June 2017"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2627-7756","authenticated-orcid":false,"given":"Augustina","family":"Delaney","sequence":"first","affiliation":[{"name":"Eagle Global Scientific, LLC  San Antonio Texas USA"},{"name":"Division of Birth Defects and Infant Disorders National Center on Birth Defects and Developmental Disabilities, CDC  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0589-5766","authenticated-orcid":false,"given":"Samantha M.","family":"Olson","sequence":"additional","affiliation":[{"name":"Division of Birth Defects and Infant Disorders National Center on Birth Defects and Developmental Disabilities, CDC  Atlanta Georgia USA"},{"name":"G<sub>2<\/sub>S Corporation  San Antonio Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6279-5561","authenticated-orcid":false,"given":"Nicole M.","family":"Roth","sequence":"additional","affiliation":[{"name":"Division of Birth Defects and Infant Disorders National Center on Birth Defects and Developmental Disabilities, CDC  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janet D.","family":"Cragan","sequence":"additional","affiliation":[{"name":"Division of Birth Defects and Infant Disorders National Center on Birth Defects and Developmental Disabilities, CDC  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4106-0953","authenticated-orcid":false,"given":"Shana","family":"Godfred\u2010Cato","sequence":"additional","affiliation":[{"name":"Division of Birth Defects and Infant Disorders National Center on Birth Defects and Developmental Disabilities, CDC  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ashley N.","family":"Smoots","sequence":"additional","affiliation":[{"name":"Division of Reproductive Health National Center for Chronic Disease Prevention and Health Promotion, CDC  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jane","family":"Fornoff","sequence":"additional","affiliation":[{"name":"llinois Department of Public Health  Springfield Illinois USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eirini","family":"Nestoridi","sequence":"additional","affiliation":[{"name":"Massachusetts Department of Public Health  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Valorie","family":"Eckert","sequence":"additional","affiliation":[{"name":"California Department of Public Health  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Allison","family":"Forkner","sequence":"additional","affiliation":[{"name":"Indiana State Department of Health  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Stolz","sequence":"additional","affiliation":[{"name":"New York State Department of Health  Albany New York USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Crawford","sequence":"additional","affiliation":[{"name":"Virginia Department of Health  Richmond Virginia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sook Ja","family":"Cho","sequence":"additional","affiliation":[{"name":"Minnesota Department of Health  St. Paul Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanda","family":"Elmore","sequence":"additional","affiliation":[{"name":"Florida Department of Health  Tallahassee Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6765-4963","authenticated-orcid":false,"given":"Peter","family":"Langlois","sequence":"additional","affiliation":[{"name":"University of Texas School of Public Health  Austin Texas USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4326-890X","authenticated-orcid":false,"given":"Amy","family":"Nance","sequence":"additional","affiliation":[{"name":"Utah Department of Health  Salt Lake City Utah USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lindsay","family":"Denson","sequence":"additional","affiliation":[{"name":"Oklahoma State Department of Health  Oklahoma City Oklahoma USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7894-0279","authenticated-orcid":false,"given":"Nina","family":"Forestieri","sequence":"additional","affiliation":[{"name":"North Carolina Department of Health and Human Services  Raleigh North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vinita O.","family":"Leedom","sequence":"additional","affiliation":[{"name":"South Carolina Department of Health and Environmental Control  Columbia South Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tri","family":"Tran","sequence":"additional","affiliation":[{"name":"Louisiana Department of Health  Baton Rouge Louisiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Valencia\u2010Prado","sequence":"additional","affiliation":[{"name":"Puerto Rico Department of Health  San Juan Puerto Rico USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5393-9984","authenticated-orcid":false,"given":"Paul","family":"Romitti","sequence":"additional","affiliation":[{"name":"University of Iowa  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jerusha E.","family":"Barton","sequence":"additional","affiliation":[{"name":"Georgia Department of Public Health  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kristen","family":"St. John","sequence":"additional","affiliation":[{"name":"Rhode Island Department of Health  Providence Rhode Island 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