{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:23:21Z","timestamp":1772670201369,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T00:00:00Z","timestamp":1660089600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2022,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Favipiravir is one of the essential antiviral drugs used for the treatment of coronavirus disease (COVID\u201019) in some countries. However, there is not enough information about used, especially in pregnancy. Therefore, in this study, it was aimed to determine the developmental toxicity of favipiravir on fetal bone development and embryonic development.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, 16 pregnant wistar albino rats were used. The rats were divided into four groups: Control (saline) and Group A (50\u2009mg\/kg\u2009\u00d7\u20095\u2009days), Group B (50\u2009mg\/kg\u2009\u00d7\u20091\u2009days\u2009+\u200920\u2009mg\/kg\u2009\u00d7\u20094\u2009days), Group C (20\u2009mg\/kg\u2009\u00d7\u20095\u2009days). Solutions were administered to the rats by oral gavage from the 10th to 14th days of pregnancy, twice a day. The skeletal system development of fetuses was examined with double skeletal staining and immunohistochemical staining methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 72 fetuses from pregnant rats, 18 in each group, were included in the study. As a result, depending on favipiravir dose increase, in experimental groups, it was determined that the statistically significant decrease on the ossification rates of anterior and posterior extremity bones, and length and weight of fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Exposure to favipiravir during pregnancy impairs bone metabolism and bone formation\u2010resorption stages and may cause developmental delay.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2073","type":"journal-article","created":{"date-parts":[[2022,8,10]],"date-time":"2022-08-10T08:18:31Z","timestamp":1660119511000},"page":"1092-1100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Investigation of developmental toxicity of favipiravir on fetal bone and embryonic development"],"prefix":"10.1002","volume":"114","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0633-9542","authenticated-orcid":false,"given":"Abdulkadir","family":"Bilir","sequence":"first","affiliation":[{"name":"Faculty of Medicine, Anatomy Department Afyonkarahisar Health Sciences University  Afyonkarahisar Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2378-1183","authenticated-orcid":false,"given":"Emre","family":"Atay","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Anatomy Department Afyonkarahisar Health Sciences University  Afyonkarahisar Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0027-5138","authenticated-orcid":false,"given":"Fatma","family":"Firat","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, Histology and Embryology Department Afyonkarahisar Health Sciences University  Afyonkarahisar Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2006-9940","authenticated-orcid":false,"given":"Yunus Emre","family":"Kundakci","sequence":"additional","affiliation":[{"name":"Faculty of Health Sciences, Physical Therapy and Rehabilitation Department Afyonkarahisar Health Sciences University  Afyonkarahisar Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,8,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1177\/0748233718823146"},{"issue":"3","key":"e_1_2_9_3_1","first-page":"157","article-title":"Nubia's mother: Being pregnant in the timeof experimental vaccines and therapeuticsfor Ebola","volume":"14","author":"Caluwaerts S.","year":"2017","journal-title":"CaluwaertsReproductive Health"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0002790"},{"issue":"3","key":"e_1_2_9_5_1","first-page":"378","article-title":"Calcification of the rabbit fetal skeleton","volume":"50","author":"Danielson M.","year":"1986","journal-title":"Growth"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2018.03.003"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.01897-20"},{"key":"e_1_2_9_8_1","volume-title":"Favimol prescribing information","author":"Favimol","year":"2020"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.2183\/pjab.93.027"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10238-020-00671-y"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00223-017-0259-2"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/QCO.0000000000000532"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijid.2020.10.069"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2014441117"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2020.198073"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2020.100159"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1055"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.137.5.8612556"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2013.31.4_suppl.149"},{"key":"e_1_2_9_20_1","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1007\/978-3-030-21573-6","volume-title":"Bone metabolism. 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