{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T17:28:04Z","timestamp":1793467684713,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T00:00:00Z","timestamp":1662422400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2023,1,15]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>We describe clinical characteristics, pregnancy, and infant outcomes in pregnant people with laboratory\u2010confirmed SARS\u2010CoV\u20102 infection by trimester of infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Study Design<\/jats:title>\n                    <jats:p>We analyzed data from the Surveillance for Emerging Threats to Mothers and Babies Network and included people with infection in 2020, with known timing of infection and pregnancy outcome. Outcomes are described by trimester of infection. Pregnancy outcomes included live birth and pregnancy loss (&lt;20\u2009weeks and \u226520\u2009weeks gestation). Infant outcomes included preterm birth (&lt;37\u2009weeks gestation), small for gestational age, birth defects, and neonatal intensive care unit admission. Adjusted prevalence ratios (aPR) were calculated for pregnancy and selected infant outcomes by trimester of infection, controlling for demographics.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Of 35,200 people included in this analysis, 50.8% of pregnant people had infection in the third trimester, 30.8% in the second, and 18.3% in the first. Third trimester infection was associated with a higher frequency of preterm birth compared to first or second trimester infection combined (17.8% vs. 11.8%; aPR 1.44 95% CI: 1.35\u20131.54). Prevalence of birth defects was 553.4\/10,000 live births, with no difference by trimester of infection.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>There were no signals for increased birth defects among infants in this population relative to national baseline estimates, regardless of timing of infection. However, the prevalence of preterm birth in people with SARS\u2010CoV\u20102 infection in pregnancy in our analysis was higher relative to national baseline data (10.0\u201310.2%), particularly among people with third trimester infection. Consequences of COVID\u201019 during pregnancy support recommended COVID\u201019 prevention strategies, including vaccination.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bdr2.2081","type":"journal-article","created":{"date-parts":[[2022,9,6]],"date-time":"2022-09-06T05:35:18Z","timestamp":1662442518000},"page":"145-159","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Pregnancy and infant outcomes by trimester of\n                    <scp>SARS\u2010CoV<\/scp>\n                    \u20102 infection in pregnancy\u2013\n                    <scp>SET\u2010NET<\/scp>\n                    , 22 jurisdictions, January 25, 2020\u2013December 31, 2020"],"prefix":"10.1002","volume":"115","author":[{"given":"Varsha","family":"Neelam","sequence":"first","affiliation":[{"name":"Centers for Disease Control and Prevention COVID\u201019 Response, Epidemiology Task Force  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily L.","family":"Reeves","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention COVID\u201019 Response, Epidemiology Task Force  Atlanta Georgia USA"},{"name":"Eagle Global Scientific, LLC  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9343-3355","authenticated-orcid":false,"given":"Kate R.","family":"Woodworth","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention COVID\u201019 Response, Epidemiology Task Force  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily","family":"O'Malley Olsen","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention COVID\u201019 Response, Epidemiology Task Force  Atlanta Georgia USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Megan 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S.","family":"Hamdan","sequence":"additional","affiliation":[{"name":"Houston Health Department  Houston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzann","family":"Beauregard","sequence":"additional","affiliation":[{"name":"New Hampshire Department of Health and Human Services  Concord New Hampshire USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Esther M.","family":"Ellis","sequence":"additional","affiliation":[{"name":"U.S. Virgin Islands Department of Health  Christiansted Virgin Islands USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Y.","family":"Seo","sequence":"additional","affiliation":[{"name":"Chicago Department of Public Health  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Bennett","sequence":"additional","affiliation":[{"name":"Centers for Disease Control and Prevention COVID\u201019 Response, Epidemiology Task Force  Atlanta 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(2022).Preterm birth among pregnant persons with severe acute respiratory syndrome coronavirus 2 infection.Journal of Perinatology.https:\/\/doi.org\/10.1038\/s41372-022-01467-6","DOI":"10.1038\/s41372-022-01467-6"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2018.01.011"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2008.05.059"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajogmf.2022.100715"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqaa089"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2021-0246-SA"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/pds.5440"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7103e1"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10995-020-03106-y"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6944e3"}],"container-title":["Birth Defects Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.2081","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bdr2.2081","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.2081","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T17:53:06Z","timestamp":1692640386000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdr2.2081"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,6]]},"references-count":37,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,1,15]]}},"alternative-id":["10.1002\/bdr2.2081"],"URL":"https:\/\/doi.org\/10.1002\/bdr2.2081","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.21203\/rs.3.rs-1670249\/v1","asserted-by":"object"}]},"ISSN":["2472-1727","2472-1727"],"issn-type":[{"value":"2472-1727","type":"print"},{"value":"2472-1727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,6]]},"assertion":[{"value":"2022-05-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-08-04","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}