{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T13:32:07Z","timestamp":1790775127123,"version":"4.1.0"},"reference-count":54,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2022,9,27]],"date-time":"2022-09-27T00:00:00Z","timestamp":1664236800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["U01DD000493"],"award-info":[{"award-number":["U01DD000493"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","award":["U01DD001037"],"award-info":[{"award-number":["U01DD001037"]}],"id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2023,2]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Nausea and vomiting of pregnancy (NVP) occurs in approximately 70% of pregnant people. Treatments include pharmacologic and herbal\/natural products. Research on the associations between NVP and its treatments and birth defects is limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We used data from the case\u2013control National Birth Defects Prevention Study (1997\u20132011) to examine whether first\u2010trimester NVP or its specific treatments were associated with 37 major birth defects. Odds ratios (aOR) and 95% confidence intervals (CIs) were adjusted for sociodemographic and reproductive factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Mothers of 66.6% of 28,628 cases and 69.9% of 11,083 controls reported first\u2010trimester NVP. Compared to no NVP, mothers with NVP had \u226510% reduction in risk of cardiac and noncardiac defects overall, and of 18 specific defects. Over\u2010the\u2010counter antiemetic use, compared to untreated NVP, was associated with \u226510% increase in risk for nine defect groups (heterotaxy, hypoplastic left heart syndrome [HLHS], aortic stenosis, cataracts, anophthalmos\/microphthalmos, biliary atresia, transverse limb deficiency, omphalocele, and gastroschisis), whereas use of prescription antiemetics increased risk \u226510% for seven defect groups (tetralogy of Fallot, HLHS, spina bifida, anopthlamos\/microphthalmos, cleft palate, craniosynostosis, and diaphragmatic hernia). We observed increased risks for promethazine and tetralogy of Fallot (aOR: 1.49, 95% CI: 1.05\u20132.10), promethazine and craniosynostosis (1.44, 1.08\u20131.92), ondansetron and cleft palate (1.66, 1.18\u20132.31), pyridoxine and heterotaxy (3.91, 1.49\u201310.27), and pyridoxine and cataracts (2.57, 1.12\u20135.88).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>NVP does not increase risks of birth defects. Our findings that some treatments for NVP increase risk of specific birth defects should be investigated further before clinical recommendations are made.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/bdr2.2096","type":"journal-article","created":{"date-parts":[[2022,9,28]],"date-time":"2022-09-28T02:29:05Z","timestamp":1664332145000},"page":"275-289","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The association of nausea and vomiting of pregnancy, its treatments, and select birth defects: Findings from the National Birth Defect Prevention Study"],"prefix":"10.1002","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4385-9686","authenticated-orcid":false,"given":"Nina L.","family":"Schrager","sequence":"first","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha E.","family":"Parker","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martha M.","family":"Werler","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for\u2009the\u2009National\u2009Birth\u2009Defects\u2009Prevention\u2009Study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,9,27]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.22865"},{"key":"e_1_2_8_3_1","doi-asserted-by":"crossref","unstructured":"Andersen J. Jimenez\u2010Solem E. &Poulsen H.(2013).Ondansetron use in early pregnancy and the risk of congenital malformations\u2014A register based nationwide cohort study. Paper presented at the International Society for Pharmacoepidemiology.","DOI":"10.1155\/2013\/364526"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.14433"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6602a1"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2007.12.006"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jclinepi.2019.07.014"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2002-34469"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a009880"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.autneu.2016.05.002"},{"key":"e_1_2_8_11_1","unstructured":"CDC. 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