{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:31:49Z","timestamp":1785544309751,"version":"3.56.0"},"reference-count":39,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T00:00:00Z","timestamp":1672704000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2023,3,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study aimed to explore the relationship between maternal periconceptional supplementation with folic acid only (FAO) or with multiple micronutrients containing folic acid (MMFA) and non\u2010syndromic cleft lip\/palate in offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>The data came from a prenatal health care system and a birth defects surveillance system in Beijing, China, from 2013 to 2018. Information on maternal FAO\/MMFA supplementation was collected by questionnaire in the first trimester, and data on cleft lip\/palate were collected at delivery or termination of pregnancy. Inverse probability weighting (IPW) by the propensity score to adjust for the confounders and Poisson regression model was used to estimate risk ratios (RRs) and their 95% confidence intervals (CIs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 63,969 participants were included in the study. Compared to the no\u2010supplementation group, the adjusted RR for the supplementation group was 0.51 (95% CI: 0.40, 0.64). And the adjusted RRs for FAO and MMFA compared to the no\u2010supplementation group were 0.56 (95% CI: 0.40, 0.76) and 0.48 (95% CI: 0.35, 0.65), respectively. Compared to supplement FAO and MMFA with less than 8\u2009days out of 10\u2009days, the adjusted RRs for FAO and MMFA with 8 or more days out of 10\u2009days were 1.17 (95% CI: 0.78, 1.75), and 2.05 (95% CI: 1.37, 3.31), respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal supplementation with micronutrients, either FAO or MMFA, during the periconceptional period can reduce the risk for non\u2010syndromic cleft lip\/palate in offspring. However, women should be more cautious with MMFA supplementation.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2146","type":"journal-article","created":{"date-parts":[[2023,1,3]],"date-time":"2023-01-03T19:44:01Z","timestamp":1672775041000},"page":"545-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The relationship between maternal periconceptional micronutrient supplementation and non\u2010syndromic cleft lip\/palate in offspring"],"prefix":"10.1002","volume":"115","author":[{"given":"Chunyi","family":"Liu","sequence":"first","affiliation":[{"name":"Institute of Reproductive and Child Health, National Health Commission Key Laboratory of Reproductive Health Peking University Beijing China"},{"name":"Department of Epidemiology and Biostatistics, School of Public Health Peking University Beijing 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