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Since nausea and vomiting are common experiences during the first trimester of pregnancy, this antiemetic has been the main drug used during this period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>To evaluate the effects of ondansetron on the embryo\u2010fetal development, which are still very contradictory, pregnant rats were exposed to therapeutic doses of ondansetron (1.7 or 2.5 mg\/kg) daily, from gestational day (GD) 6 to 15.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No clinical signs of toxicity were observed in dams during the treatment. Although the hemato\u2010biochemical parameters were similar among the groups, histological changes, as well as a reduction in the weight of kidney were found in the treated dams. After fetal examination, no visceral and skeletal abnormalities were observed in treated fetuses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In conclusion, therapeutic doses of ondansetron have low teratogenic potential in rats. 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