{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T03:46:46Z","timestamp":1784605606900,"version":"3.55.0"},"reference-count":58,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T00:00:00Z","timestamp":1675900800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004586","name":"Funda\u00e7\u00e3o Carlos Chagas Filho de Amparo \u00e0 Pesquisa do Estado do Rio de Janeiro","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2023,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Gastroschisis is a congenital abnormality of the abdominal wall which worldwide prevalence is increasing with time. Up to now, young maternal age is the main factor associated with gastroschisis. Brazil has a great proportion of adolescent mothers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To estimate prevalence of gastroschisis in Brazil, explore the effect of very young maternal age, and analyze regional distribution and time trends.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cross\u2010sectional population\u2010based study using data from official national information systems from 2007 to 2020, covering 9,831 gastroschisis cases. Low maternal age was assessed as risk factor through odds ratio. Prevalence time trends by maternal age and geographic area were analyzed using joinpoint regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall prevalence of gastroschisis in Brazil was 2.47 per 10,000 births. From first to last biennium, there was a 23% relative increase. Last biennium prevalence was higher in the Central\u2010west region and lower in the Northeast.<\/jats:p><jats:p>Compared to mothers of 20\u201334\u2009years old (YO), the odds\u2010ratio for prevalence and 95% confidence intervals for gastroschisis were, as follows: (a) 10\u201314 YO\u20144.9 (4.3,5.5); (b) 15\u201319 YO\u20143.6 (3.5,3.8); and (c) 35\u201349 YO\u20140.3 (95% CI 0.3, 0.4).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Prevalence of gastroschisis in Brazil relatively increased 23% from 2007 to 2020. This happened in all maternal age groups. Differences between regions may be associated to data quality. Young mothers had a higher prevalence of gastroschisis and still higher for those under 15 YO. Mother age over 34 YO was a protective factor.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2156","type":"journal-article","created":{"date-parts":[[2023,2,9]],"date-time":"2023-02-09T13:45:35Z","timestamp":1675950335000},"page":"633-646","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Trends in prevalence of gastroschisis in Brazil from 2007 to 2020: A national population\u2010based cross\u2010sectional study"],"prefix":"10.1002","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3875-4751","authenticated-orcid":false,"given":"Claudia Tavares","family":"Regadas","sequence":"first","affiliation":[{"name":"Universidade Federal do Rio de Janeiro  Rio de Janeiro RJ Brazil"},{"name":"Hospital Federal dos Servidores do Estado  Rio de Janeiro RJ Brazil"},{"name":"Funda\u00e7\u00e3o Oswaldo Cruz  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0273-6911","authenticated-orcid":false,"given":"Claudia Caminha","family":"Escosteguy","sequence":"additional","affiliation":[{"name":"Hospital Federal dos Servidores do Estado  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5493-494X","authenticated-orcid":false,"given":"Sandra Costa","family":"Fonseca","sequence":"additional","affiliation":[{"name":"Universidade Federal Fluminense  Niter\u00f3i RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3361-3626","authenticated-orcid":false,"given":"Rejane Sobrino","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1757-3940","authenticated-orcid":false,"given":"Claudia Medina","family":"Coeli","sequence":"additional","affiliation":[{"name":"Universidade Federal do Rio de Janeiro  Rio de Janeiro RJ Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,2,9]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19138079"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.3701"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/archdischild-2019-318412"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2019.12.005"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01371903"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-4755-10-S1-S2"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1896"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/14767058.2018.1529163"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-50935-1"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1590\/S1679-49742021000100030"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2020.03.010"},{"key":"e_1_2_8_13_1","volume-title":"Statistical power analysis for the behavioral sciences","author":"Coehn J.","year":"1988"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.2000.tb11645.x"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.38116\/brua22art1"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/jech.2003.008466"},{"key":"e_1_2_8_17_1","unstructured":"Departamento de Inform\u00e1tica do Sistema \u00danico de Sa\u00fade [DATASUS]. (2020).Sistema de Informa\u00e7\u00f5es sobre Mortalidade (SIM).http:\/\/datasus1.saude.gov.br\/informacoes-de-saude\/tabnet"},{"key":"e_1_2_8_18_1","unstructured":"Departamento de Inform\u00e1tica do SUS [DATASUS]. (2022).Sistema de Informa\u00e7\u00f5es sobre Nascidos Vivos (SINASC).https:\/\/datasus.saude.gov.br\/informacoes-de-saude-tabnet\/"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1590\/0103-11042017S220"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2021.04.007"},{"key":"e_1_2_8_21_1","unstructured":"Empresa Brasileira de Pesquisa Agropecu\u00e1ria (Embrapa). (2022).Soja em n\u00fameros (safra 2020\/21).https:\/\/www.embrapa.br\/soja\/cultivos\/soja1\/dados\u2010economicos#:~:text=Consumo%20interno%20(processamento)%20de%20soja %24%2028%2C561%20bilh\u00f5es(2020)"},{"key":"e_1_2_8_22_1","unstructured":"Escola da Defensoria P\u00fablica do Estado de S\u00e3o Paulo [EDEPE]. (2018).Aborto legal.http:\/\/www.mpsp.mp.br\/portal\/page\/portal\/documentacao_e_divulgacao\/doc_biblioteca\/bibli_servicos_produtos\/BibliotecaDigital\/BibDigitalLivros\/TodosOsLivros\/Aborto_Legal.pdf"},{"issue":"12","key":"e_1_2_8_23_1","first-page":"700","article-title":"Interpreting estimates of treatment effects: Implications for managed care","volume":"33","author":"Faraone S. V.","year":"2008","journal-title":"Pharmacy & Therapeutics"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00383-010-2701-7"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2017.06.013"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/pd.4562"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12401"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0102-311X2008000200023"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2016.12.015"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6502a2"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.332.7536.250"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097-0258(20000215)19:3<335::aid-sim336>3.3.co;2-q"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1053\/jpsu.2002.36191"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2007.07.005"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep33333"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.25248\/REAS.e9725.2022"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12800"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2007.00820.x"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1590\/s0102-311x2009000800008"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.31607"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1590\/1806-9282.65.9.1209"},{"key":"e_1_2_8_42_1","unstructured":"National Cancer Institute. (2022).Joinpoint regression program Version 4.9.1.0. Statistical Methodology and Applications Branch.https:\/\/surveillance.cancer.gov\/help\/joinpoint\/tech-help\/citation"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1413-81232012000400017"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1590\/1413-812320141910.08512014"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12556"},{"key":"e_1_2_8_46_1","unstructured":"R CoreTeam. (2013).R: A language and environment for statistical computing (R\u20104.0.2). R Foundation for Statistical Computing.http:\/\/www.r-project.org\/"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-3401797"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1703"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23374"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12326"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.22237\/jmasm\/1257035100"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1157\/13043426"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-3016.2008.00990.x"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2019.104936"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1590\/0102-311X00214918"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60932-6"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2010.01.023"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2016.07.011"},{"key":"e_1_2_8_59_1","unstructured":"World Health Organization Center for Disease Control and Research & International Clearinghouse for Birth Defects Surveillance and Research. (2014).Annual Report 2014\u2014International Clearinghouse for Birth Defects Surveillance and Research (ICBDSR).http:\/\/www.icbdsr.org\/wp-content\/annual_report\/Report2014.pdf"}],"container-title":["Birth Defects Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.2156","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/bdr2.2156","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.2156","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T06:47:11Z","timestamp":1692686831000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdr2.2156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,9]]},"references-count":58,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,4]]}},"alternative-id":["10.1002\/bdr2.2156"],"URL":"https:\/\/doi.org\/10.1002\/bdr2.2156","archive":["Portico"],"relation":{},"ISSN":["2472-1727","2472-1727"],"issn-type":[{"value":"2472-1727","type":"print"},{"value":"2472-1727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,2,9]]},"assertion":[{"value":"2022-09-07","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-01-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-09","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}