{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T13:07:00Z","timestamp":1791205620389,"version":"4.1.0"},"reference-count":326,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T00:00:00Z","timestamp":1684800000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2023,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Some per\u2010 and poly\u2010fluoroalkyl substances (PFAS) cause neonatal mortality and lower birth weight in rodents. We constructed an Adverse Outcome Pathway (AOP) network for neonatal mortality and lower birth weight in rodents, comprising three putative AOPs. We then assessed strengths of the evidence for the AOPs and applicability to PFAS. Finally, we considered the relevance of this AOP network to human health.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Literature searches targeted PFAS, peroxisome proliferator\u2010activated receptor (PPAR) agonists, other nuclear receptors, relevant tissues, and developmental targets. We used reviews of established biology and described results of studies with prenatal PFAS exposure that assessed birth weight and neonatal survival. Molecular initiating events (MIEs) and key events (KEs) were proposed and strengths of KE relationships (KERs), applicability to PFAS, and human relevance were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Neonatal mortality has been observed in rodents following gestational exposure to most longer chain PFAS studied, often coincident with lower birth weight. In AOP 1, PPAR\u03b1 activation and PPAR\u03b3 activation or downregulation are MIEs; placental insufficiency, fetal nutrient restriction, neonatal hepatic glycogen deficit, and hypoglycemia are KEs leading to neonatal mortality and lower birth weight. In AOP 2, constitutive androstane receptor (CAR) and pregnane X receptor (PXR) activation upregulates Phase II metabolism, lowering maternal circulating thyroid hormones. In AOP 3, disrupted pulmonary surfactant function and <jats:bold>PPAR\u03b3<\/jats:bold> downregulation cause neonatal airway collapse and mortality from respiratory failure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>It is likely that different components of this AOP network will apply to different PFAS, largely determined by which nuclear receptors they activate. The MIEs and KEs in this AOP network can occur in humans, but differences in PPAR structure and function, and the timeline of liver and lung development, suggest that humans may be less susceptible to this AOP network. This putative AOP network elucidates knowledge gaps and research needed to better understand the developmental toxicity of PFAS.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2185","type":"journal-article","created":{"date-parts":[[2023,5,23]],"date-time":"2023-05-23T11:49:54Z","timestamp":1684842594000},"page":"1011-1062","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["A putative adverse outcome network for neonatal mortality and lower birth weight in rodents: Applicability to per\u2010 and polyfluoroalkyl substances and relevance to human health"],"prefix":"10.1002","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5881-1768","authenticated-orcid":false,"given":"John M.","family":"Rogers","sequence":"first","affiliation":[{"name":"ToxStrategies LLC  Raleigh North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8931-617X","authenticated-orcid":false,"given":"Melissa M.","family":"Heintz","sequence":"additional","affiliation":[{"name":"ToxStrategies LLC  Asheville North Carolina USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chad M.","family":"Thompson","sequence":"additional","affiliation":[{"name":"ToxStrategies LLC  Katy Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurie C.","family":"Haws","sequence":"additional","affiliation":[{"name":"ToxStrategies LLC  Austin Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,5,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2008.10.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2008.05.061"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfm110"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-016-1888-3"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3159"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2017.01.114"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfs318"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.1c01304"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425255.2016.1223626"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/etc.34"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.10334"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.01.074"},{"key":"e_1_2_8_14_1","unstructured":"ATSDR. (2021).Toxicological profile for perfluoroalkyls.https:\/\/www.atsdr.cdc.gov\/toxprofiles\/tp200.pdf"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2013-1401"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2020.11.008"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1040866"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.23004"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/s1097-2765(00)80209-9"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/142082"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2018.07.025"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/0278-6915(93)90225-n"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2011.06.012"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP6233"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2020.152565"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecoenv.2022.114314"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/ftox.2022.881347"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.2741\/1062"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01965164"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/758562"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2010.07.004"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-197210000-00004"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0960-894x(01)00188-3"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061738"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxlet.2013.01.025"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2011.09.006"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2014.0066"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/69.1.244"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2009.01.004"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-14384-z"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.10598"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1053\/plac.1999.0522"},{"key":"e_1_2_8_43_1","first-page":"33","volume-title":"Endocrine and hormonal toxicology","author":"Capen C. C.","year":"1999"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425255.2013.754010"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/0192623320905803"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.913901"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20205055"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfn147"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C100462200"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrb.10045"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.20981"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2020.106204"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2022.107631"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2021.107056"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP4372"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.emcon.2021.10.004"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.612320"},{"key":"e_1_2_8_58_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408444.2013.835784"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-017-2094-7"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1097\/JOM.0b013e3181965d80"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408440591007304"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1080\/15287390802361763"},{"key":"e_1_2_8_63_1","first-page":"328","article-title":"Postnatal thrombosis (PNT) in newborn rat by hypolipemic agents. Preliminary results. [Abstract]","volume":"12","author":"Dange M.","year":"1975","journal-title":"Teratology"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2014.12.012"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.1998.274.2.R339"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9112395"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M605623200"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.1080\/jmf.11.4.258.261"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1400331"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2012-1064"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.114.121798"},{"issue":"4","key":"e_1_2_8_72_1","first-page":"221","article-title":"Lung development","volume":"3","author":"DiFiore J. W.","year":"1994","journal-title":"Seminars in Pediatric Surgery"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M600931200"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909731106"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.etap.2015.12.009"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI28859"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI88894"},{"key":"e_1_2_8_78_1","unstructured":"DuPont. (2010).An oral (gavage) reproduction\/developmental toxicity screening study of H\u201028548 in mice (U.S. EPA OPPTS 870.4300)."},{"key":"e_1_2_8_79_1","unstructured":"DuPont\u201024009. (2008).Repeated dose oral toxicity 7\u2010day gavage study in rats."},{"key":"e_1_2_8_80_1","unstructured":"DuPont\u201024447. (2008).A 28\u2010day oral (gavage) toxicity study of H\u201028397 in rats with a 28\u2010day recovery. OECD Test Guideline 407. L. Study conducted by WIL Research Laboratories."},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.115.228239"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.70.12.3454"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb18649.x"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2011.12.014"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-010-0572-2"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.3109\/10408444.2013.835786"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph19042385"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2022.116136"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu11122870"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.8.6715"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-020-02961-6"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04601.x"},{"key":"e_1_2_8_93_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986708786848677"},{"key":"e_1_2_8_94_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13231"},{"key":"e_1_2_8_95_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1900132"},{"key":"e_1_2_8_96_1","doi-asserted-by":"publisher","DOI":"10.1293\/tox.2018-0042"},{"key":"e_1_2_8_97_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.140.6.1453"},{"key":"e_1_2_8_98_1","doi-asserted-by":"publisher","DOI":"10.1124\/dmd.110.035568"},{"key":"e_1_2_8_99_1","doi-asserted-by":"publisher","DOI":"10.1210\/me.2015-1145"},{"key":"e_1_2_8_100_1","doi-asserted-by":"publisher","DOI":"10.1016\/0026-0495(87)90177-6"},{"key":"e_1_2_8_101_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00093.2015"},{"key":"e_1_2_8_102_1","doi-asserted-by":"publisher","DOI":"10.1210\/mend.13.9.0341"},{"key":"e_1_2_8_103_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqaa106"},{"key":"e_1_2_8_104_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI107519"},{"key":"e_1_2_8_105_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.1977.232.5.E456"},{"key":"e_1_2_8_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri1748"},{"key":"e_1_2_8_107_1","doi-asserted-by":"publisher","DOI":"10.1021\/tx00037a003"},{"key":"e_1_2_8_108_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1999.8737"},{"key":"e_1_2_8_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2014.03.012"},{"key":"e_1_2_8_110_1","doi-asserted-by":"publisher","DOI":"10.1159\/000085895"},{"key":"e_1_2_8_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2017.09.003"},{"key":"e_1_2_8_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrb.20059"},{"key":"e_1_2_8_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrb.10046"},{"key":"e_1_2_8_114_1","doi-asserted-by":"publisher","DOI":"10.1530\/jme-15-0313"},{"key":"e_1_2_8_115_1","doi-asserted-by":"publisher","DOI":"10.3390\/toxics10110684"},{"key":"e_1_2_8_116_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11213474"},{"key":"e_1_2_8_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0168-8278(02)00212-x"},{"key":"e_1_2_8_118_1","doi-asserted-by":"publisher","DOI":"10.1159\/000243363"},{"key":"e_1_2_8_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2015.08.002"},{"key":"e_1_2_8_120_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf00304510"},{"key":"e_1_2_8_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-020-02936-7"},{"key":"e_1_2_8_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2022.133873"},{"key":"e_1_2_8_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-020-02939-4"},{"key":"e_1_2_8_124_1","doi-asserted-by":"publisher","DOI":"10.2217\/fca-2017-0019"},{"key":"e_1_2_8_125_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1007248007372"},{"key":"e_1_2_8_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.510230312"},{"key":"e_1_2_8_127_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/21.12.2159"},{"key":"e_1_2_8_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2007.03.006"},{"key":"e_1_2_8_129_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2008-1518"},{"key":"e_1_2_8_130_1","doi-asserted-by":"publisher","DOI":"10.1095\/biolreprod.105.045914"},{"key":"e_1_2_8_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2009.02.021"},{"key":"e_1_2_8_132_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.37.63"},{"key":"e_1_2_8_133_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24142545"},{"key":"e_1_2_8_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2021.152789"},{"key":"e_1_2_8_135_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13643-016-0263-z"},{"key":"e_1_2_8_136_1","doi-asserted-by":"publisher","DOI":"10.1159\/000047172"},{"key":"e_1_2_8_137_1","doi-asserted-by":"publisher","DOI":"10.3727\/105221618X15293258688953"},{"key":"e_1_2_8_138_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.00051"},{"key":"e_1_2_8_139_1","doi-asserted-by":"publisher","DOI":"10.1002\/9780470720684.ch10"},{"key":"e_1_2_8_140_1","doi-asserted-by":"publisher","DOI":"10.2337\/db09-0824"},{"key":"e_1_2_8_141_1","doi-asserted-by":"publisher","DOI":"10.1051\/jbio:2008034"},{"key":"e_1_2_8_142_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-239749"},{"key":"e_1_2_8_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/ppul.21030"},{"key":"e_1_2_8_144_1","doi-asserted-by":"publisher","DOI":"10.1002\/tox.21996"},{"key":"e_1_2_8_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm4024"},{"key":"e_1_2_8_146_1","doi-asserted-by":"publisher","DOI":"10.1515\/bchm.1997.378.7.651"},{"key":"e_1_2_8_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmet.2014.02.002"},{"key":"e_1_2_8_148_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005176-198300201-00003"},{"key":"e_1_2_8_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2008.10.008"},{"key":"e_1_2_8_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2011.01.002"},{"key":"e_1_2_8_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2008.11.021"},{"key":"e_1_2_8_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0169-409x(99)00005-8"},{"key":"e_1_2_8_153_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00204-015-1522-9"},{"key":"e_1_2_8_154_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.24.18.7931-7940.2004"},{"key":"e_1_2_8_155_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200412022"},{"key":"e_1_2_8_156_1","doi-asserted-by":"publisher","DOI":"10.2133\/dmpk.23.8"},{"key":"e_1_2_8_157_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/120.9.1016"},{"key":"e_1_2_8_158_1","doi-asserted-by":"publisher","DOI":"10.1002\/jemt.20046"},{"key":"e_1_2_8_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2006.04.001"},{"key":"e_1_2_8_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2005.06.003"},{"key":"e_1_2_8_161_1","doi-asserted-by":"publisher","DOI":"10.1159\/000242173"},{"key":"e_1_2_8_162_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9102306"},{"key":"e_1_2_8_163_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature03029"},{"key":"e_1_2_8_164_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.0c04651"},{"key":"e_1_2_8_165_1","doi-asserted-by":"publisher","DOI":"10.1039\/c8tx00008e"},{"key":"e_1_2_8_166_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1432-1033.1996.0001u.x"},{"key":"e_1_2_8_167_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.143.7.8898"},{"key":"e_1_2_8_168_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201900214R"},{"key":"e_1_2_8_169_1","doi-asserted-by":"publisher","DOI":"10.1093\/jn\/129.4.820"},{"key":"e_1_2_8_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2004.09.008"},{"key":"e_1_2_8_171_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfm128"},{"key":"e_1_2_8_172_1","first-page":"119","volume-title":"Developmental toxicology","author":"Lau C.","year":"1994"},{"key":"e_1_2_8_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2020.152522"},{"key":"e_1_2_8_174_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfj105"},{"key":"e_1_2_8_175_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfg122"},{"key":"e_1_2_8_176_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00376.2018"},{"key":"e_1_2_8_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13961"},{"key":"e_1_2_8_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2006.05.013"},{"key":"e_1_2_8_179_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00372.2015"},{"key":"e_1_2_8_180_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.8b06978"},{"key":"e_1_2_8_181_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S310163"},{"key":"e_1_2_8_182_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9060677"},{"key":"e_1_2_8_183_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11010086"},{"key":"e_1_2_8_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2009.01.027"},{"key":"e_1_2_8_185_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/9210748"},{"key":"e_1_2_8_186_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.140.3.6602"},{"key":"e_1_2_8_187_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00048.2018"},{"key":"e_1_2_8_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2005.07.019"},{"key":"e_1_2_8_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2009.08.002"},{"key":"e_1_2_8_190_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313601200"},{"key":"e_1_2_8_191_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00055"},{"key":"e_1_2_8_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2012.11.040"},{"key":"e_1_2_8_193_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.179440"},{"key":"e_1_2_8_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2019.02.017"},{"key":"e_1_2_8_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2013.11.006"},{"key":"e_1_2_8_196_1","doi-asserted-by":"publisher","DOI":"10.1515\/dmdi-2013-0009"},{"key":"e_1_2_8_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envres.2008.06.001"},{"key":"e_1_2_8_198_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2014.8"},{"key":"e_1_2_8_199_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp700103m"},{"key":"e_1_2_8_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/0960-0760(94)90089-2"},{"key":"e_1_2_8_201_1","doi-asserted-by":"publisher","DOI":"10.1210\/endo.142.7.8280"},{"key":"e_1_2_8_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2013.01.005"},{"key":"e_1_2_8_203_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0131"},{"key":"e_1_2_8_204_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19051396"},{"key":"e_1_2_8_205_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2022.08.011"},{"key":"e_1_2_8_206_1","doi-asserted-by":"publisher","DOI":"10.1080\/10408444.2016.1271972"},{"key":"e_1_2_8_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2021.153024"},{"key":"e_1_2_8_208_1","doi-asserted-by":"publisher","DOI":"10.1289\/EHP5297"},{"key":"e_1_2_8_209_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI1567"},{"key":"e_1_2_8_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0031-3955(16)34968-9"},{"key":"e_1_2_8_211_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-198710000-00014"},{"key":"e_1_2_8_212_1","doi-asserted-by":"publisher","DOI":"10.1021\/jp304412p"},{"key":"e_1_2_8_213_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.jom.0000052958.59271.10"},{"key":"e_1_2_8_214_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00420-007-0213-0"},{"key":"e_1_2_8_215_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.051052"},{"key":"e_1_2_8_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2019.110663"},{"key":"e_1_2_8_217_1","doi-asserted-by":"publisher","DOI":"10.1621\/nrs.13002"},{"key":"e_1_2_8_218_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0112655"},{"key":"e_1_2_8_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2010.07.008"},{"key":"e_1_2_8_220_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.53.1.14"},{"key":"e_1_2_8_221_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2015.02.012"},{"key":"e_1_2_8_222_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0008055"},{"key":"e_1_2_8_223_1","doi-asserted-by":"publisher","DOI":"10.1203\/01.PDR.0000047643.26484.48"},{"key":"e_1_2_8_224_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3512"},{"key":"e_1_2_8_225_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/22.3.519"},{"key":"e_1_2_8_226_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/572405"},{"key":"e_1_2_8_227_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2022.107408"},{"key":"e_1_2_8_228_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010433"},{"key":"e_1_2_8_229_1","doi-asserted-by":"publisher","DOI":"10.1006\/taap.1998.8413"},{"key":"e_1_2_8_230_1","doi-asserted-by":"publisher","DOI":"10.1677\/joe.0.1760247"},{"key":"e_1_2_8_231_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.toxrep.2020.12.019"},{"key":"e_1_2_8_232_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI88893"},{"key":"e_1_2_8_233_1","doi-asserted-by":"publisher","DOI":"10.1006\/gcen.2000.7520"},{"key":"e_1_2_8_234_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2004-1350"},{"key":"e_1_2_8_235_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00125-016-4061-x"},{"key":"e_1_2_8_236_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0006796"},{"key":"e_1_2_8_237_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2018.00265"},{"key":"e_1_2_8_238_1","doi-asserted-by":"publisher","DOI":"10.3109\/00498254.2013.847990"},{"key":"e_1_2_8_239_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113137"},{"key":"e_1_2_8_240_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.8455205"},{"key":"e_1_2_8_241_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2011.226399"},{"key":"e_1_2_8_242_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2017.05.013"},{"key":"e_1_2_8_243_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfn025"},{"key":"e_1_2_8_244_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2009.01.007"},{"key":"e_1_2_8_245_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2007.06.095"},{"key":"e_1_2_8_246_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yrtph.2014.10.003"},{"key":"e_1_2_8_247_1","doi-asserted-by":"publisher","DOI":"10.1530\/eje.0.1320206"},{"key":"e_1_2_8_248_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mce.2006.02.009"},{"key":"e_1_2_8_249_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2004-2265"},{"key":"e_1_2_8_250_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.10.6885"},{"key":"e_1_2_8_251_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0211"},{"key":"e_1_2_8_252_1","doi-asserted-by":"publisher","DOI":"10.2337\/diab.24.12.1101"},{"key":"e_1_2_8_253_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0300-483x(02)00511-5"},{"key":"e_1_2_8_254_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/68.1.249"},{"key":"e_1_2_8_255_1","doi-asserted-by":"publisher","DOI":"10.1002\/aja.1001310202"},{"key":"e_1_2_8_256_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20041837"},{"issue":"8","key":"e_1_2_8_257_1","first-page":"449","article-title":"Placental glycogen metabolism in diabetic pregnancy","volume":"27","author":"Shafrir E.","year":"1991","journal-title":"Israel Journal of Medical Sciences"},{"key":"e_1_2_8_258_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ydbio.2012.08.021"},{"key":"e_1_2_8_259_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-0528.1971.tb00214.x"},{"key":"e_1_2_8_260_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi00072a015"},{"issue":"10","key":"e_1_2_8_261_1","first-page":"2611","article-title":"Cell lineages and oval cell progenitors in rat liver development","volume":"51","author":"Shiojiri N.","year":"1991","journal-title":"Cancer Research"},{"key":"e_1_2_8_262_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfh130"},{"key":"e_1_2_8_263_1","doi-asserted-by":"publisher","DOI":"10.1071\/RD11219"},{"key":"e_1_2_8_264_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.05-5410fje"},{"key":"e_1_2_8_265_1","doi-asserted-by":"publisher","DOI":"10.1186\/1465-9921-11-69"},{"key":"e_1_2_8_266_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.placenta.2022.05.015"},{"key":"e_1_2_8_267_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1530-0277.1986.tb05614.x"},{"key":"e_1_2_8_268_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2016.08.006"},{"key":"e_1_2_8_269_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)30189-9"},{"key":"e_1_2_8_270_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2019.104656"},{"key":"e_1_2_8_271_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.cir.98.19.2088"},{"key":"e_1_2_8_272_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-81265-1_27"},{"key":"e_1_2_8_273_1","doi-asserted-by":"publisher","DOI":"10.1097\/EDE.0000000000000903"},{"key":"e_1_2_8_274_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2005-0371"},{"key":"e_1_2_8_275_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2021.153056"},{"key":"e_1_2_8_276_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2018.12.065"},{"key":"e_1_2_8_277_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfab113"},{"key":"e_1_2_8_278_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfaa043"},{"key":"e_1_2_8_279_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfl135"},{"key":"e_1_2_8_280_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.39.97"},{"key":"e_1_2_8_281_1","doi-asserted-by":"publisher","DOI":"10.1159\/000501906"},{"key":"e_1_2_8_282_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.3780334"},{"key":"e_1_2_8_283_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddaa249"},{"key":"e_1_2_8_284_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-015-1500-x"},{"key":"e_1_2_8_285_1","doi-asserted-by":"publisher","DOI":"10.1016\/0300-483x(79)90026-x"},{"key":"e_1_2_8_286_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1996.tb18620.x"},{"key":"e_1_2_8_287_1","doi-asserted-by":"publisher","DOI":"10.1080\/15298668091425310"},{"key":"e_1_2_8_288_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2016.185"},{"key":"e_1_2_8_289_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0773.1989.tb00648.x"},{"key":"e_1_2_8_290_1","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.120.000071"},{"key":"e_1_2_8_291_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfl014"},{"key":"e_1_2_8_292_1","doi-asserted-by":"publisher","DOI":"10.1289\/ehp.1408837"},{"key":"e_1_2_8_293_1","doi-asserted-by":"publisher","DOI":"10.1002\/etc.4124"},{"key":"e_1_2_8_294_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfu199"},{"key":"e_1_2_8_295_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4612306"},{"key":"e_1_2_8_296_1","doi-asserted-by":"publisher","DOI":"10.1677\/jme.0.0310541"},{"key":"e_1_2_8_297_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21165723"},{"key":"e_1_2_8_298_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.0c06569"},{"key":"e_1_2_8_299_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7652557"},{"key":"e_1_2_8_300_1","doi-asserted-by":"publisher","DOI":"10.1053\/plac.2002.0855"},{"key":"e_1_2_8_301_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.est.2c00957"},{"key":"e_1_2_8_302_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2023.162579"},{"key":"e_1_2_8_303_1","volume-title":"Placental insufficiency","author":"Wardinger J. E.","year":"2022"},{"key":"e_1_2_8_304_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddy343"},{"key":"e_1_2_8_305_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202000963"},{"key":"e_1_2_8_306_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfp055"},{"key":"e_1_2_8_307_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-015-8736-9"},{"key":"e_1_2_8_308_1","doi-asserted-by":"publisher","DOI":"10.1155\/2008\/527048"},{"key":"e_1_2_8_309_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-2275(20)32207-0"},{"key":"e_1_2_8_310_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reprotox.2011.09.009"},{"key":"e_1_2_8_311_1","doi-asserted-by":"publisher","DOI":"10.1093\/toxsci\/kfn166"},{"key":"e_1_2_8_312_1","doi-asserted-by":"publisher","DOI":"10.1155\/2010\/282896"},{"key":"e_1_2_8_313_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemphyslip.2010.01.003"},{"key":"e_1_2_8_314_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2009.10.025"},{"key":"e_1_2_8_315_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.13.9116"},{"key":"e_1_2_8_316_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2022.153281"},{"key":"e_1_2_8_317_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.35.527"},{"key":"e_1_2_8_318_1","doi-asserted-by":"publisher","DOI":"10.2131\/jts.33.219"},{"key":"e_1_2_8_319_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2014.102"},{"key":"e_1_2_8_320_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2021.108633"},{"key":"e_1_2_8_321_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M302847200"},{"key":"e_1_2_8_322_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddz290"},{"key":"e_1_2_8_323_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj1080325"},{"key":"e_1_2_8_324_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbagrm.2015.10.001"},{"key":"e_1_2_8_325_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envpol.2020.115535"},{"key":"e_1_2_8_326_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chemosphere.2023.137748"},{"key":"e_1_2_8_327_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2014.06.020"}],"container-title":["Birth Defects Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.2185","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T04:46:12Z","timestamp":1692506772000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdr2.2185"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,23]]},"references-count":326,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,6,15]]}},"alternative-id":["10.1002\/bdr2.2185"],"URL":"https:\/\/doi.org\/10.1002\/bdr2.2185","archive":["Portico"],"relation":{},"ISSN":["2472-1727","2472-1727"],"issn-type":[{"value":"2472-1727","type":"print"},{"value":"2472-1727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,23]]},"assertion":[{"value":"2022-12-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-04-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-23","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}