{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T09:51:17Z","timestamp":1779270677128,"version":"3.51.4"},"reference-count":25,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T00:00:00Z","timestamp":1684972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2023,6,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To assess demographics and outcomes up to 3\u2009years of age among children with cytomegalovirus (CMV) infection in California neonatal intensive care units (NICUs) during 2010\u20132021.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The California Perinatal Quality Care Collaborative (CPQCC) collects data on all very low birth weight (VLBW, birth weight\u2009\u2264\u20091500\u2009g) and acutely ill infants with birth weight\u2009&gt;\u20091500\u2009g across 92% of NICUs in California. VLBW infants and those with neurological conditions are referred to a statewide high\u2010risk infant follow\u2010up (HRIF) program. CMV infection was defined as a positive culture or PCR identified during the NICU hospitalization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>During 2010\u20132021, CMV reporting rates averaged 3.5\/1000 VLBW infants (<jats:italic>n<\/jats:italic>\u2009=\u2009205) and 1.1\/1000 infants &gt;1500\u2009g (<jats:italic>n<\/jats:italic>\u2009=\u2009128). Among all 333 infants with CMV, 314 (94%) were discharged home alive, 271 (86%) were referred for HRIF and 205 (65%) had \u22651 visit. Whereas infants born to mothers &lt;20\u2009years of age had highest CMV reporting rates and those born to Hispanic mothers comprised 49% of all infected infants, they had the highest loss of follow\u2010up. At the 12\u2010month visit (<jats:italic>n<\/jats:italic>\u2009=\u2009152), 19 (13%) infants with CMV had bilateral blindness and 18 (12%) had hearing loss. At the 24\u2010month visit, 5 (5%) of 103 had severe cerebral palsy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Among infants admitted to the NICU, those with CMV diagnoses may over represent infants with more severe CMV disease and outcomes. The CPQCC and HRIF program findings may help inform implementation of surveillance for congenital CMV infection in other U.S. states and guide strategies to reduce disparities in access to services.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2203","type":"journal-article","created":{"date-parts":[[2023,5,25]],"date-time":"2023-05-25T08:48:55Z","timestamp":1685004535000},"page":"1093-1100","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Early childhood outcomes of <scp>NICU<\/scp> graduates with cytomegalovirus infection in <scp>California<\/scp>"],"prefix":"10.1002","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2499-4786","authenticated-orcid":false,"given":"Tatiana M.","family":"Lanzieri","sequence":"first","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianyao","family":"Lu","sequence":"additional","affiliation":[{"name":"California Perinatal Quality Care Collaborative (CPQCC)  Stanford California USA"},{"name":"Stanford University School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mihoko V.","family":"Bennett","sequence":"additional","affiliation":[{"name":"California Perinatal Quality Care Collaborative (CPQCC)  Stanford California USA"},{"name":"Stanford University School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan R.","family":"Hintz","sequence":"additional","affiliation":[{"name":"California Perinatal Quality Care Collaborative (CPQCC)  Stanford California USA"},{"name":"Stanford University School of Medicine  Stanford California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Sugerman","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sheila C.","family":"Dollard","sequence":"additional","affiliation":[{"name":"Division of Viral Diseases, National Center for Immunization and Respiratory Diseases Centers for Disease Control and Prevention  Atlanta Georgia USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Megan H.","family":"Pesch","sequence":"additional","affiliation":[{"name":"Department of Pediatrics University of Michigan  Ann Arbor Michigan USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria A. L.","family":"Jocson","sequence":"additional","affiliation":[{"name":"California Children's Services (CCS), Department of Health Care Services Integrated Systems of Care  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henry C.","family":"Lee","sequence":"additional","affiliation":[{"name":"California Perinatal Quality Care Collaborative (CPQCC)  Stanford California USA"},{"name":"University of California San Diego  San Diego California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,5,25]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"American Academy of Pediatrics. (2018).Cytomegalovirus infection. In: Kimberlin DW Brady MT Jackson MA Long SS (eds.)Red book: 2018 Report of the committee on infectious diseases 31st ed. American Academy of Pediatrics."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1080\/00365549950163969"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.104.1.55"},{"key":"e_1_2_8_5_1","unstructured":"California Perinatal Quality Care Collaborative. (2022).NICU data manual of definitions."},{"key":"e_1_2_8_6_1","unstructured":"California Perinatal Quality Care Collaborative. (2023).Quality improvement projects."},{"key":"e_1_2_8_7_1","unstructured":"Department of Health Care Services California Children's Services. (2016).High risk infant follow\u2010up program letter."},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2431-13-59"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2016-2128"},{"issue":"196","key":"e_1_2_8_10_1","article-title":"Racial and ethnic differences in the prevalence of congenital cytomegalovirus infection","volume":"200","author":"Fowler K. B.","year":"2018","journal-title":"The Journal of Pediatrics"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2017-0635"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2010.03.002"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2011-000118"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-0076"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcv.2007.10.015"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpeds.2019.08.050"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(83)92138-4"},{"key":"e_1_2_8_18_1","volume-title":"Congenital cytomegalovirus surveillance in the United States","author":"Raines K.","year":"2022"},{"key":"e_1_2_8_19_1","unstructured":"Raines K. Rau A. Clark R. H. Sugerman D. E. &Lanzieri T. M.(2023).Congenital cytomegalovirus among infants in U.S. neonatal intensive care units during 2010\u20102020. Abstract submitted to the 2023 Congenital Cytomegalovirus Public Health and Policy Conference."},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpedi.1982.03970460026006"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.30020"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0039-1683958"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-2217"},{"key":"e_1_2_8_24_1","unstructured":"Vermont Oxford Network. (2022).Databases and reporting."},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2019.4532"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1097\/INF.0b013e31822d9640"}],"container-title":["Birth Defects Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.2203","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,20]],"date-time":"2023-08-20T04:45:50Z","timestamp":1692506750000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdr2.2203"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,25]]},"references-count":25,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2023,6,15]]}},"alternative-id":["10.1002\/bdr2.2203"],"URL":"https:\/\/doi.org\/10.1002\/bdr2.2203","archive":["Portico"],"relation":{},"ISSN":["2472-1727","2472-1727"],"issn-type":[{"value":"2472-1727","type":"print"},{"value":"2472-1727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,5,25]]},"assertion":[{"value":"2023-02-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-10","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-05-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}