{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T22:47:59Z","timestamp":1767826079443,"version":"3.49.0"},"reference-count":35,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T00:00:00Z","timestamp":1687305600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K23 HD102589"],"award-info":[{"award-number":["K23 HD102589"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2023,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>TARP syndrome, characterized by <jats:bold>t<\/jats:bold>alipes equinovarus, <jats:bold>a<\/jats:bold>trial septal defect, <jats:bold>R<\/jats:bold>obin sequence, and <jats:bold>p<\/jats:bold>ersistent left superior vena cava, is an X\u2010linked recessive condition caused by deleterious variants in <jats:italic>RBM10<\/jats:italic>. Vitelline vascular remnants (VVR) are a rare vitelline duct anomaly with approximately 26 cases previously reported. There are no previously reported cases of VVRs in patients with TARP syndrome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>We present a male neonate diagnosed with TARP syndrome via trio whole exome sequencing who had classic features of this syndrome, although his course was additionally complicated by feeding intolerance with multiple episodes of abdominal distension. Serial imaging and contrast studies of the upper GI tract and small bowel demonstrated small bowel obstruction of unclear etiology. Given the poor prognosis associated with this condition, life\u2010sustaining measures were withdrawn, and he passed away at 38\u2009days of age. On autopsy, a VVR was unexpectedly identified with proximal bowel dilation, explaining his feeding intolerance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We highlight the importance of full post\u2010mortem examination in understanding the complete spectrum of manifestations of genetic syndromes and provide a review of the literature.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2212","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T07:22:08Z","timestamp":1687332128000},"page":"1216-1221","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Vitelline vascular remnant causing intestinal obstruction in a patient with TARP syndrome"],"prefix":"10.1002","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8947-5453","authenticated-orcid":false,"given":"Jacklyn","family":"Omorodion","sequence":"first","affiliation":[{"name":"Division of Genetics and Genomics, Department of Pediatrics Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Tannenbaum","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Department of Pediatrics Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John Patrick","family":"O'Neill","sequence":"additional","affiliation":[{"name":"Department of Pathology Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christy","family":"Cummings","sequence":"additional","affiliation":[{"name":"Division of Newborn Medicine, Department of Pediatrics Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8162-5031","authenticated-orcid":false,"given":"Monica H.","family":"Wojcik","sequence":"additional","affiliation":[{"name":"Division of Genetics and Genomics, Department of Pediatrics Boston Children's Hospital  Boston Massachusetts USA"},{"name":"Division of Newborn Medicine, Department of Pediatrics Boston Children's Hospital  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,21]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.32677\/IJCR.2020.v06.i11.017"},{"key":"e_1_2_8_3_1","first-page":"559","volume-title":"Pediatric gastrointestinal and liver disease","author":"Campbell B. 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