{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,31]],"date-time":"2025-10-31T08:04:59Z","timestamp":1761897899542,"version":"3.40.5"},"reference-count":69,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T00:00:00Z","timestamp":1690848000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003810","name":"Hospital de Cl\u00ednicas de Porto Alegre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007381","name":"Instituto Nacional de Gen\u00e9tica M\u00e9dica Populacional","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007381","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007381","name":"Instituto Nacional de Gen\u00e9tica M\u00e9dica Populacional","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007381","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003810","name":"Hospital de Cl\u00ednicas de Porto Alegre","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003810","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2023,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Zika virus (ZIKV) is a human teratogen that causes congenital Zika syndrome (CZS). AXL, TLR3, and STAT2 are proteins involved in the ZIKV's entry into cells (AXL) and host's immune response (TLR3 and STAT2). In this study, we evaluated the role of genetic polymorphisms in these three genes as risk factors to CZS, and highlighted which proteins that interact with them could be important for ZIKV infection and teratogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>We evaluate eighty\u2010eight children exposed to ZIKV during the pregnancy, 40 with CZS and 48 without congenital anomalies. The evaluated polymorphisms in <jats:italic>AXL<\/jats:italic> (rs1051008), <jats:italic>TLR3<\/jats:italic> (rs3775291), and <jats:italic>STAT2<\/jats:italic> (rs2066811) were genotyped using TaqMan\u00ae Genotyping Assays. A protein\u2013protein interaction network was created in STRING database and analyzed in Cytoscape software.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We did not find any statistical significant association among the polymorphisms and the occurrence of CZS. Through the analyses of the network composed by AXL, TLR3, STAT2 and their interactions targets, we found that EGFR and SRC could be important proteins for the ZIKV infection and its teratogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In summary, our results demonstrated that the evaluated polymorphisms do not seem to represent risk factors for CZS; however, EGFR and SRC appear to be important proteins that should be investigated in future studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2232","type":"journal-article","created":{"date-parts":[[2023,8,1]],"date-time":"2023-08-01T10:43:19Z","timestamp":1690886599000},"page":"1500-1512","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Investigation of the impact of <scp><i>AXL<\/i><\/scp>, <scp><i>TLR3<\/i><\/scp>, and <scp><i>STAT2<\/i><\/scp> in congenital Zika syndrome through genetic polymorphisms and protein\u2013protein interaction network analyses"],"prefix":"10.1002","volume":"115","author":[{"given":"Julia A.","family":"Gomes","sequence":"first","affiliation":[{"name":"Instituto Nacional de Gen\u00e9tica M\u00e9dica Populacional (INAGEMP)  Porto Alegre Brazil"},{"name":"Laborat\u00f3rio de Medicina Gen\u00f4mica (LMG), Centro de Pesquisa Experimental (CPE) Hospital de Cl\u00ednicas de Porto Alegre (HCPA)  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduarda","family":"Sgarioni","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Medicina Gen\u00f4mica (LMG), Centro de Pesquisa Experimental (CPE) Hospital de Cl\u00ednicas de Porto Alegre (HCPA)  Porto Alegre Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Gen\u00e9tica e Biologia Molecular (PPGBM), Departamento de Gen\u00e9tica Universidade Federal do Rio Grande do Sul (UFRGS)  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliano A.","family":"Boquett","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Gen\u00e9tica M\u00e9dica Populacional (INAGEMP)  Porto Alegre Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Sa\u00fade da Crian\u00e7a e do Adolescente (PPGSCA), Faculdade de Medicina Universidade Federal do Rio Grande do Sul (UFRGS)  Porto Alegre Brazil"},{"name":"Department of Neurology University of California  San Francisco California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thayne W.","family":"Kowalski","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Gen\u00e9tica M\u00e9dica Populacional (INAGEMP)  Porto Alegre Brazil"},{"name":"Laborat\u00f3rio de Medicina Gen\u00f4mica (LMG), Centro de Pesquisa Experimental (CPE) Hospital de Cl\u00ednicas de Porto Alegre (HCPA)  Porto Alegre Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Gen\u00e9tica e Biologia Molecular (PPGBM), Departamento de Gen\u00e9tica Universidade Federal do Rio Grande do Sul (UFRGS)  Porto Alegre Brazil"},{"name":"Sistema Nacional de Informa\u00e7\u00e3o sobre Agentes Teratog\u00eanicos (SIAT) Servi\u00e7o de Gen\u00e9tica M\u00e9dica, Hospital de Cl\u00ednicas de Porto Alegre (HCPA)  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucas R.","family":"Fraga","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Medicina Gen\u00f4mica (LMG), Centro de Pesquisa Experimental (CPE) Hospital de Cl\u00ednicas de Porto Alegre (HCPA)  Porto Alegre Brazil"},{"name":"Sistema Nacional de Informa\u00e7\u00e3o sobre Agentes Teratog\u00eanicos (SIAT) Servi\u00e7o de Gen\u00e9tica M\u00e9dica, Hospital de Cl\u00ednicas de Porto Alegre (HCPA)  Porto Alegre Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Medicina: Ci\u00eancias M\u00e9dicas (PPGCM)  Porto Alegre Brazil"},{"name":"Departamento de Ci\u00eancias Morfol\u00f3gicas, Instituto de Ci\u00eancias B\u00e1sicas da Sa\u00fade Universidade Federal do Rio Grande do Sul (UFRGS)  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana Cl\u00e1udia P.","family":"Ter\u00e7as\u2010Trettel","sequence":"additional","affiliation":[{"name":"Departamento de Enfermagem Universidade do Estado de Mato Grosso (UNEMAT)  Tangar\u00e1 da Serra Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Sa\u00fade Coletiva Universidade Federal de Mato Grosso (UFMT)  Cuiab\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana H.","family":"da Silva","sequence":"additional","affiliation":[{"name":"Secretaria Municipal de Sa\u00fade de Tangar\u00e1 da Serra  Tangar\u00e1 da Serra Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beth\u00e2nia F. R.","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"Funda\u00e7\u00e3o Hospital de Cl\u00ednicas do Acre (FUNDACRE)  Rio Branco Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marcial F.","family":"Galera","sequence":"additional","affiliation":[{"name":"Departamento de Pediatria, Faculdade de Medicina Universidade Federal de Mato Grosso (UFMT)  Cuiab\u00e1 Brazil"},{"name":"Hospital Universit\u00e1rio J\u00falio M\u00fcller (HUJM), Universidade Federal de Mato Grosso (UFMT) Empresa Brasileira de Servi\u00e7os Hospitalares (EBSERH)  Cuiab\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thalita M.","family":"de Oliveira","sequence":"additional","affiliation":[{"name":"Hospital Universit\u00e1rio J\u00falio M\u00fcller (HUJM), Universidade Federal de Mato Grosso (UFMT) Empresa Brasileira de Servi\u00e7os Hospitalares (EBSERH)  Cuiab\u00e1 Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Denise F.","family":"Carvalho de Andrade","sequence":"additional","affiliation":[{"name":"Universidade Estadual do Cear\u00e1 (UECE)  Fortaleza Brazil"},{"name":"Centro Universit\u00e1rio Christus (UNICHRISTUS)  Fortaleza Brazil"},{"name":"Faculdade Paulo Pican\u00e7o  Fortaleza Brazil"},{"name":"Hospital Geral Dr. C\u00e9sar Cals  Fortaleza Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Isabella F.","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Centro Universit\u00e1rio Christus (UNICHRISTUS)  Fortaleza Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lav\u00ednia","family":"Sch\u00fcler\u2010Faccini","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Gen\u00e9tica M\u00e9dica Populacional (INAGEMP)  Porto Alegre Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Gen\u00e9tica e Biologia Molecular (PPGBM), Departamento de Gen\u00e9tica Universidade Federal do Rio Grande do Sul (UFRGS)  Porto Alegre Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Sa\u00fade da Crian\u00e7a e do Adolescente (PPGSCA), Faculdade de Medicina Universidade Federal do Rio Grande do Sul (UFRGS)  Porto Alegre Brazil"},{"name":"Sistema Nacional de Informa\u00e7\u00e3o sobre Agentes Teratog\u00eanicos (SIAT) Servi\u00e7o de Gen\u00e9tica M\u00e9dica, Hospital de Cl\u00ednicas de Porto Alegre (HCPA)  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6339-4869","authenticated-orcid":false,"given":"Fernanda S. L.","family":"Vianna","sequence":"additional","affiliation":[{"name":"Instituto Nacional de Gen\u00e9tica M\u00e9dica Populacional (INAGEMP)  Porto Alegre Brazil"},{"name":"Laborat\u00f3rio de Medicina Gen\u00f4mica (LMG), Centro de Pesquisa Experimental (CPE) Hospital de Cl\u00ednicas de Porto Alegre (HCPA)  Porto Alegre Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Gen\u00e9tica e Biologia Molecular (PPGBM), Departamento de Gen\u00e9tica Universidade Federal do Rio Grande do Sul (UFRGS)  Porto Alegre Brazil"},{"name":"Sistema Nacional de Informa\u00e7\u00e3o sobre Agentes Teratog\u00eanicos (SIAT) Servi\u00e7o de Gen\u00e9tica M\u00e9dica, Hospital de Cl\u00ednicas de Porto Alegre (HCPA)  Porto Alegre Brazil"},{"name":"Programa de P\u00f3s\u2010Gradua\u00e7\u00e3o em Medicina: Ci\u00eancias M\u00e9dicas (PPGCM)  Porto Alegre Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,8]]},"reference":[{"volume-title":"Discovering the Brain","year":"1992","author":"Ackerman S.","key":"e_1_2_10_2_1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2019.01.018"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aay6736"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.764746"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23010489"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2016.02.010"},{"key":"e_1_2_10_8_1","unstructured":"Brasil. Minist\u00e9rio da Sa\u00fade. (2021).Situa\u00e7\u00e3o epidemiol\u00f3gica da s\u00edndrome cong\u00eanita associada \u00e0 infec\u00e7\u00e3o pelo v\u00edrus Zika 2015 a 2020. Available at:http:\/\/plataforma.saude.gov.br\/anomalias-congenitas\/boletim-epidemiologico-SVS-04-2021.pdf"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2016.07.018"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)00562-6"},{"key":"e_1_2_10_11_1","first-page":"642","article-title":"Immune recognition versus immune evasion systems in Zika virus infection","volume":"11","author":"Chan Y. T.","year":"2023","journal-title":"Biomedicine"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-017-0092-4"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1261\/rna.052571.115"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-080317-062231"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.04.014"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.38170"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0035-9203(52)90042-4"},{"key":"e_1_2_10_18_1","unstructured":"Ensembl database. (2023). Available on:https:\/\/www.ensembl.org\/index.html"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30902-3"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0135991"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/v13020325"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2022.2145061"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2016.05.009"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm11051351"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.14301"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-018-0116-y"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00354-15"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2019.03.003"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.03.058"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201847483"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201642627"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep30490"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15877"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2140-08.2008"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-019-0324-7"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3210"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2016.12.045"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2016650117"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapediatrics.2016.3982"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2014.03.013"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0810372105"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1089\/vim.2019.0082"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.03.012"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jped.2016.02.009"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0208543"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01018-18"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13577-021-00530-2"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/v6010069"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01050-20"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2207.151990"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1618029113"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2015.01.003"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01195-21"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-30342-3"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiz392"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2016-0343-OA"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/v11100970"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.1239303"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2015.12.008"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389557516666160321114917"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.04.011"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-00549-7_4"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1131"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1097\/RMR.0000000000000192"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1128\/CMR.00022-07"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2016.11.034"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12250-020-00264-9"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2016.11.011"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009183"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.0030059"}],"container-title":["Birth Defects Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.2232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,10,2]],"date-time":"2023-10-02T07:26:45Z","timestamp":1696231605000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdr2.2232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8]]},"references-count":69,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2023,10]]}},"alternative-id":["10.1002\/bdr2.2232"],"URL":"https:\/\/doi.org\/10.1002\/bdr2.2232","archive":["Portico"],"relation":{},"ISSN":["2472-1727","2472-1727"],"issn-type":[{"type":"print","value":"2472-1727"},{"type":"electronic","value":"2472-1727"}],"subject":[],"published":{"date-parts":[[2023,8]]},"assertion":[{"value":"2023-02-13","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-07-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-08-01","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}