{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,16]],"date-time":"2026-06-16T01:28:03Z","timestamp":1781573283072,"version":"3.54.5"},"reference-count":54,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T00:00:00Z","timestamp":1691712000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2023,10,15]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Sugammadex is a modified gamma\u2010cyclodextrin that has been developed with the goal of reversing the steroidal neuromuscular blocking agents. The aim of the present study is to investigate the effects of different sugammadex doses on embryologic and neural tube development in an early\u2010stage chick embryo model.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 100 specific pathogen\u2010free, fertilized domestic chicken eggs were randomly divided into five groups (<jats:italic>n<\/jats:italic>\u2009=\u200920, each), and placed in an automatic cycle incubator. The eggs in the \u201ccontrol (C)\u201d group were incubated without administration of any drug till the end of the experiment. Sub\u2010blastodermic administration of 0.9% NaCl as vehicle control (VC) and different doses of sugammadex solutions prepared with the latter [2\u2009mg\/mL (LD), 4\u2009mg\/mL (MD), 16\u2009mg\/mL (HD)] were performed at 30\u2009hr of incubation. All embryos were removed from the eggs at 72\u2009hr when they were expected to reach Hamburger\u2010Hamilton (HH) stages 19\u201320, then they were fixed, and evaluated histo\u2010morphologically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Embryonic development was not observed in 11 eggs (1 in C, 1 in VC; 3 in LD, 3 in MD, and 3 in HD). All the developed embryos were compatible with the HH stages 19\u201320. A neural tube closure defect was detected in one embryo in the HD group. No statistically significant difference was found between the groups in terms of embryonic and neural tube developments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No significant association was found between the drug and adverse outcomes; however, a trend with dosing was seen. Further studies are required before conclude on safety and extrapolate these results to human beings.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2237","type":"journal-article","created":{"date-parts":[[2023,8,11]],"date-time":"2023-08-11T13:20:35Z","timestamp":1691760035000},"page":"1598-1607","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The influence of different sugammadex doses on neural tube development in early\u2010stage chick embryos"],"prefix":"10.1002","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3299-6706","authenticated-orcid":false,"given":"Asude","family":"Ayhan","sequence":"first","affiliation":[{"name":"Department of Anaesthesiology and Reanimation Baskent University School of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6955-9839","authenticated-orcid":false,"given":"Ekin","family":"Efe","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Baskent University School of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3047-0305","authenticated-orcid":false,"given":"Pinar A.","family":"Fidan","sequence":"additional","affiliation":[{"name":"Department of Histology and Embryology Baskent University School of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3243-7843","authenticated-orcid":false,"given":"Oguzhan E.","family":"Efe","sequence":"additional","affiliation":[{"name":"Department of Pharmacology Baskent University School of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6166-2601","authenticated-orcid":false,"given":"Eylem Gul","family":"Ates","sequence":"additional","affiliation":[{"name":"Department of Biostatistics Baskent University School of Medicine  Ankara Turkey"},{"name":"Institutional Big Data Management Unit Middle East Technical University  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0471-3177","authenticated-orcid":false,"given":"Fikret","family":"Sahinturk","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Baskent University School of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0153-3012","authenticated-orcid":false,"given":"Selim","family":"Ayhan","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery Baskent University School of Medicine  Ankara Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,8,11]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/s20195546"},{"key":"e_1_2_10_3_1","unstructured":"Administration U. 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