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This review explores the secondary goal of CLARITY\u2010BPA: to identify endpoints or technologies from CLARITY\u2010BPA and prior\/concurrent literature from these laboratories that may enhance the capacity of rodent toxicity studies to detect endocrine disrupting chemicals (EDCs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A systematic literature search was conducted with search terms for BPA and the CLARITY\u2010BPA participants. Relevant studies employed a laboratory rodent model and reported results on 1 of the 10 organs\/organ systems evaluated in CLARITY\u2010BPA (brain and behavior, cardiac, immune, mammary gland, ovary, penile function, prostate gland and urethra, testis and epididymis, thyroid hormone and metabolism, and uterus). Study design and findings were summarized, and a risk\u2010of\u2010bias assessment was conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Several endpoints and methods were identified as potentially helpful to detect effects of EDCs. For example, molecular and quantitative morphological approaches were sensitive in detecting alterations in early postnatal development of the brain, ovary, and mammary glands. Hormone challenge studies mimicking human aging reported increased susceptibility of the prostate to disease following developmental BPA exposure. Statistical analyses for nonmonotonic dose responses, and computational approaches assessing multiple treatment\u2010related outcomes concurrently in linked hormone\u2010sensitive organ systems, reported effects at low BPA doses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This review provided an opportunity to evaluate the unique insights provided by nontraditional assessments in CLARITY\u2010BPA to identify technologies and endpoints to enhance detection of EDCs in future studies.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2238","type":"journal-article","created":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T11:55:43Z","timestamp":1693396543000},"page":"1345-1397","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Evaluating endocrine disrupting chemicals: A perspective on the novel assessments in <scp>CLARITY\u2010BPA<\/scp>"],"prefix":"10.1002","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2880-1179","authenticated-orcid":false,"given":"Kembra L.","family":"Howdeshell","sequence":"first","affiliation":[{"name":"Division of Translational Toxicology National Institute of Environmental Health Sciences (NIEHS)  Research Triangle Park North Carolina USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brandiese E. 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