{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,13]],"date-time":"2025-05-13T14:33:23Z","timestamp":1747146803721,"version":"3.40.5"},"reference-count":58,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T00:00:00Z","timestamp":1695168000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2023,11,15]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>The relationship between maternal age (MA<\/jats:styled-content>) and birth defects (BD<\/jats:styled-content>) has been extensively studied while much less research, mostly with discordant results, has focused on the risk of paternal age (PA<\/jats:styled-content>) for BD<\/jats:styled-content>. Furthermore, no consensus has been reached on the best way to control the association of PA<\/jats:styled-content> with MA.<\/jats:styled-content><\/jats:p><\/jats:sec>Objectives<\/jats:title>The aim of the study was to evaluate the risk of PA increase, at 1\u2010year intervals, for selected BD, especially controlling for the confounding effect of MA.<\/jats:p><\/jats:sec>Methods<\/jats:title>The sample comprised of 27,944 liveborns presenting 1 of 18 selected isolated BD. Conditional logistic regressions were applied to evaluate the risk of advanced PA and its yearly increase, adjusting by MA and other variables.<\/jats:p><\/jats:sec>Results<\/jats:title>Of the 18 analyzed BD, only the risk for preaxial polydactyly (PreP) showed a significant association with increasing PA, while advanced MA was of low risk. For esophageal and anal atresia, associations with both PA and MA increases were observed.<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Results support the hypothesis of advanced PA as a risk factor for PreP and helps clarify the so far unexplained nonrandom association between this defect and Down syndrome.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2252","type":"journal-article","created":{"date-parts":[[2023,9,20]],"date-time":"2023-09-20T11:09:03Z","timestamp":1695208143000},"page":"1866-1875","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Paternal age and risk for selected birth defects in a large South American sample"],"prefix":"10.1002","volume":"115","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7924-0776","authenticated-orcid":false,"given":"Juan A.","family":"Gili","sequence":"first","affiliation":[{"name":"Laboratorio de Epidemiolog\u00eda Gen\u00e9tica, Centro de Educaci\u00f3n M\u00e9dica e 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