{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:04:25Z","timestamp":1753862665571,"version":"3.41.2"},"reference-count":25,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,18]],"date-time":"2023-10-18T00:00:00Z","timestamp":1697587200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100009633","name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","doi-asserted-by":"publisher","award":["RO1\u2010HD051804"],"award-info":[{"award-number":["RO1\u2010HD051804"]}],"id":[{"id":"10.13039\/100009633","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>Talipes equinovarus (clubfoot) is a congenital lower foot deformity that results from a neuromuscular deficiency, but the precise etiology remains elusive. Vitamin D is important for fetal neuromuscular development. In this study, we investigated the association between dietary vitamin D intake during pregnancy and incidence of clubfoot in neonates, since such a question has thus far been overlooked.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a secondary analysis of data collected in the United States, between 2007 and 2011 for a case\u2013control study of children born with clubfoot. Participating mothers were interviewed by telephone about dietary and other health and life\u2010style indicators. Exposure to vitamin D was recorded as the average daily intake of dietary vitamin D over a period of 6\u2009months before pregnancy began. Odds ratios (ORs) and 95% confidence intervals (CIs) were estimated using logistic regression.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The dataset included 2667 study participants, of which 663 were cases. Logistic regression showed no significant association between dietary vitamin D or log<jats:sub>10<\/jats:sub>(Vitamin D) intake during pregnancy and incidence of clubfoot in neonates (OR\u2009=\u20091.00, CI\u2009=\u20091.00\u20131.00, OR\u2009=\u20091.51, CI\u2009=\u20090.83\u20132.82, respectively). No interaction in the regression model was found between vitamin D and other predictor variables. Results were not confounded by supplement intake of vitamin D during pregnancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Results show no evidence of an association between dietary vitamin D intake and incidence of clubfoot in neonates. The lack of association is not confounded by consumption of vitamin D supplements during pregnancy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2261","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T05:01:06Z","timestamp":1697691666000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Investigating the association between vitamin D dietary intake during pregnancy and incidence of clubfoot in neonates"],"prefix":"10.1002","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9676-1266","authenticated-orcid":false,"given":"Haitham T.","family":"Idriss","sequence":"first","affiliation":[{"name":"School of Public Health Imperial College of Science, Technology and Medicine  London UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martha M.","family":"Werler","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Boston University School of Public Health  Boston Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,10,18]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"ACOG. (2023).Vitamin D: Screening and supplementation during pregnancy (2011). ACOG (Accessed April 7 2023).https:\/\/www.acog.org\/clinical\/clinical-guidance\/committee-opinion\/articles\/2011\/07\/vitamin-d-screening-and-supplementation-during-pregnancy."},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2017.09.006"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-2250"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.21315\/mjms2018.25.4.12"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3475"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.21.4.290"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/BPO.0000000000001191"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.12672"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1242\/dev.160093"},{"key":"e_1_2_8_11_1","unstructured":"FAO. (2021).Food composition data (Fao.org) (Accessed 30 December 2022).http:\/\/www.fao.org\/3\/y4705e\/y4705E16.htm."},{"issue":"2","key":"e_1_2_8_12_1","first-page":"52","article-title":"Folic acid supplementation and pregnancy: More than just neural tube defect prevention","volume":"4","author":"Greenberg J. A.","year":"2011","journal-title":"Reviews in Obstetrics & Gynaecology"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jcot.2020.11.002"},{"key":"e_1_2_8_14_1","unstructured":"Physiopedia. (2020).Introduction to clubfoot (Accessed 30 December 2022).https:\/\/www.physio-pedia.com\/Introduction_to_Clubfoot."},{"volume-title":"Congenital clubfoot: Fundamentals of treatment","year":"1996","author":"Ponseti I. 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(2021).Vitamin D supplementation during pregnancy (Accessed 30 December 2022).https:\/\/apps.who.int\/iris\/bitstream\/handle\/10665\/85313\/9789241504935_eng.pdf;jsessionid=E7A5D37D6F57939CC42D6D82308B8355?sequence=1."},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2018-02713"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0174378"}],"container-title":["Birth Defects Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.2261","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T05:26:15Z","timestamp":1720675575000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdr2.2261"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,18]]},"references-count":25,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/bdr2.2261"],"URL":"https:\/\/doi.org\/10.1002\/bdr2.2261","archive":["Portico"],"relation":{},"ISSN":["2472-1727","2472-1727"],"issn-type":[{"type":"print","value":"2472-1727"},{"type":"electronic","value":"2472-1727"}],"subject":[],"published":{"date-parts":[[2023,10,18]]},"assertion":[{"value":"2023-05-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-26","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-10-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2261"}}