{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,6]],"date-time":"2025-11-06T01:06:13Z","timestamp":1762391173498,"version":"3.41.2"},"reference-count":42,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,13]],"date-time":"2023-12-13T00:00:00Z","timestamp":1702425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>For over two decades, a daily folic acid (FA) supplementation has been recommended for women of childbearing age with epilepsy. This recommendation is based on evidence that FA administration before conception and during pregnancy can decrease the risk of fetal malformations in the general population, improve cognitive development, and reduce the risk of autistic traits in children exposed in utero to antiepileptic drugs (AEDs).<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to evaluate FA supplementation rate in nonpregnant women of childbearing age with epilepsy and its relation to AED type and number.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed the computerized database and the medical records of all the women who had a first visit to our outpatient epilepsy clinic (Shamir\u2010Assaf Harofeh Medical Center, Zerifin, Israel) during a 10\u2010year period (2012\u20132021).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Only 61 (22%) of 282 nonpregnant women of childbearing age with epilepsy treated with AEDs received FA supplementation. Ninety\u2010two (33%) of the women were treated with AED polytherapy, and 41 (15%) received valproic acid in monotherapy or polytherapy. FA supplementation rate was higher in women aged \u226440 versus &gt;40 (25% vs. 8.5%) (<jats:italic>p<\/jats:italic>\u2009=\u2009.004). No correlation was found between FA supplementation and AED type or number.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FA supplementation rate was low and was unaffected by AED treatment. Patient and physician\u2010targeted interventions should be implemented to increase FA prescription and patient adherence.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2283","type":"journal-article","created":{"date-parts":[[2023,12,14]],"date-time":"2023-12-14T09:20:18Z","timestamp":1702545618000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Folic acid supplementation in women of childbearing age with epilepsy: No association with type or number of antiepileptic drugs"],"prefix":"10.1002","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5415-7482","authenticated-orcid":false,"given":"Revital","family":"Gandelman\u2010Marton","sequence":"first","affiliation":[{"name":"Neurology Department Shamir\u2010Assaf Harofeh Medical Center  Zerifin Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jacques","family":"Theitler","sequence":"additional","affiliation":[{"name":"Neurology Department Shamir\u2010Assaf Harofeh Medical Center  Zerifin Israel"},{"name":"Faculty of Medicine Tel Aviv University  Tel Aviv Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000200669"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2019.106260"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001182"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0131130"},{"issue":"2","key":"e_1_2_8_6_1","first-page":"160","article-title":"Association of Folic Acid Supplementation during pregnancy with the risk of autistic traits in children exposed to antiepileptic drugs in utero","volume":"75","author":"Bj\u00f8rk M.","year":"2018","journal-title":"Journal of American Medical Association Neurology"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2013.2270"},{"issue":"4","key":"e_1_2_8_8_1","first-page":"32","article-title":"Mechanisms of teratogenesis: Folic acid and antiepileptic therapy","volume":"42","author":"Dansky L. V.","year":"1992","journal-title":"Neurology"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2014.12.026"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1528-1167.2009.02130.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2017.05.007"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1748"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907328"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00381-023-05910-7"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0387-7604(02)00163-8"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eplepsyres.2019.106250"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000005031"},{"issue":"1","key":"e_1_2_8_18_1","first-page":"34","article-title":"Epilepsy and pregnancy","volume":"28","author":"Li Y.","year":"2022","journal-title":"Continuum"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0803531"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(12)70323-X"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000008757"},{"key":"e_1_2_8_22_1","unstructured":"Ministry of Health. (2021).Births in Israel.https:\/\/www.gov.il\/he\/departments\/publications\/reports\/live-birth-in-israel"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2014.07.015"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2014.12.039"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0140-6736(91)90133-A"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1093\/nutrit\/nuy025"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1177\/17562864221101687"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2014.12.006"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pediatrneurol.2017.12.007"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1579"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2011.1433"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2020.107688"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13709"},{"issue":"4","key":"e_1_2_8_34_1","first-page":"391","article-title":"Association of maternal prenatal vitamin use with risk for autism spectrum disorder recurrence in young siblings","volume":"76","author":"Schmidt R. J.","year":"2019","journal-title":"Journal of American Medical Association Psychiatry"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(80)90886-7"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.00322"},{"key":"e_1_2_8_37_1","unstructured":"The Association of Family Physician in Israel. (n.d.).https:\/\/www.health.gov.il\/hozer\/bz01_2018.pdf"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000001772"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1097\/WCO.0000000000000659"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2020.107569"},{"issue":"11","key":"e_1_2_8_41_1","first-page":"1130","article-title":"Cancer risk in children of mothers with epilepsy and high\u2010dose folic acid use during pregnancy","volume":"79","author":"Vegrim H. M.","year":"2022","journal-title":"Journal of American Medical Association Neurology"},{"issue":"11","key":"e_1_2_8_42_1","article-title":"Monotherapy treatment of epilepsy in pregnancy: Congenital malformation outcomes in the child","volume":"11","author":"Weston J.","year":"2016","journal-title":"Cochrane Database of Systematic Reviews"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/epi.13007"}],"container-title":["Birth Defects Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.2283","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,11]],"date-time":"2024-07-11T05:26:10Z","timestamp":1720675570000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdr2.2283"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,13]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,1]]}},"alternative-id":["10.1002\/bdr2.2283"],"URL":"https:\/\/doi.org\/10.1002\/bdr2.2283","archive":["Portico"],"relation":{},"ISSN":["2472-1727","2472-1727"],"issn-type":[{"type":"print","value":"2472-1727"},{"type":"electronic","value":"2472-1727"}],"subject":[],"published":{"date-parts":[[2023,12,13]]},"assertion":[{"value":"2023-08-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2283"}}