{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:04:33Z","timestamp":1753862673140,"version":"3.41.2"},"reference-count":45,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T00:00:00Z","timestamp":1704412800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Orofacial clefts (OFCs) include cleft palate (CP), cleft lip (CL), and cleft lip with cleft palate (CLP) and require multidisciplinary healthcare services. Alberta, Canada has a publicly funded, universal access healthcare system. This study determined publicly funded healthcare costs for children with an OFC and compared these costs to children without congenital anomalies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective population\u2010based cohort analysis used the Alberta Congenital Anomalies Surveillance System to identify children born between 2002 and 2018 with an isolated OFC. They were matched 1:1 to a reference cohort based on sex and year of birth. The study population included 1614 children, from birth to 17\u2009years of age linked to administrative databases to estimate annual inpatient and outpatient costs. Average annual all\u2010cause costs were compared using two\u2010sample independent <jats:italic>t<\/jats:italic> tests.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean total cleft\u2010related costs per patient were highest for children with CLP ($74,138 CAD, standard deviation (<jats:italic>SD<\/jats:italic>) $43,447 CAD), followed by CP ($53,062 CAD, <jats:italic>SD<\/jats:italic> $74,366 CAD), and CL ($35,288 CAD, <jats:italic>SD<\/jats:italic> $49,720 CAD).<\/jats:p><jats:p>The mean total all\u2010cause costs per child were statistically significantly higher (<jats:italic>p<\/jats:italic>\u2009&lt;\u2009.001) in children with an OFC ($56,305 CAD, <jats:italic>SD<\/jats:italic> $57,744 CAD) compared to children without a congenital anomaly ($18,600 CAD, <jats:italic>SD<\/jats:italic> $61,300 CAD).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Despite public health strategies to mitigate risk factors, the trend for OFCs has remained stable in Alberta, Canada for over 20\u2009years. The costs reported are useful to other jurisdictions for comparison, and to families, healthcare professionals, service planners, and policy makers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2295","type":"journal-article","created":{"date-parts":[[2024,1,5]],"date-time":"2024-01-05T10:29:02Z","timestamp":1704450542000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Publicly funded healthcare costs associated with orofacial clefts for children born in Alberta, Canada between 2002 and 2018"],"prefix":"10.1002","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5496-5084","authenticated-orcid":false,"given":"Tanya","family":"Bedard","sequence":"first","affiliation":[{"name":"Alberta Congenital Anomalies Surveillance System Alberta Health Services  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8568-7598","authenticated-orcid":false,"given":"R. Brian","family":"Lowry","sequence":"additional","affiliation":[{"name":"Alberta Congenital Anomalies Surveillance System Alberta Health Services  Calgary Alberta Canada"},{"name":"Departments of Pediatrics and Medical Genetics University of Calgary and Alberta Children's Hospital  Calgary Alberta Canada"},{"name":"Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Crawford","sequence":"additional","affiliation":[{"name":"Alberta Perinatal Health Program Alberta Health Services  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ting (Grace)","family":"Wang","sequence":"additional","affiliation":[{"name":"Provincial Research Data Services Alberta Health Services  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeffrey","family":"Bakal","sequence":"additional","affiliation":[{"name":"Provincial Research Data Services Alberta Health Services  Edmonton Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amy","family":"Metcalfe","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Foothills Medical Centre Alberta Health Services  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A. Robertson","family":"Harrop","sequence":"additional","affiliation":[{"name":"Departments of Pediatrics and Surgery Cumming School of Medicine, University of Calgary  Calgary Alberta Canada"},{"name":"Section of Plastic Surgery University of Calgary and Alberta Children's Hospital  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xin","family":"Grevers","sequence":"additional","affiliation":[{"name":"Alberta Congenital Anomalies Surveillance System Alberta Health Services  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Ann","family":"Thomas","sequence":"additional","affiliation":[{"name":"Alberta Congenital Anomalies Surveillance System Alberta Health Services  Calgary Alberta Canada"},{"name":"Departments of Pediatrics and Medical Genetics University of Calgary and Alberta Children's Hospital  Calgary Alberta Canada"},{"name":"Alberta Children's Hospital Research Institute, Cumming School of Medicine, University of Calgary  Calgary Alberta Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,1,5]]},"reference":[{"key":"e_1_2_9_2_1","unstructured":"Alberta Dental Association. 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