{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T20:09:58Z","timestamp":1793390998538,"version":"4.5.0"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2024,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Craniosynostosis is a prevalent craniofacial malformation in Finland; however, comprehensive population\u2010based epidemiological data are limited. This study aimed to estimate the total and birth prevalence of craniosynostosis in Finland from 1987 to 2010 and examine temporal trends.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We collected the data from nationwide registers maintained by the Finnish Institute for Health and Welfare and Statistics Finland, as well as treating hospitals, encompassing live births, stillbirths, terminations for fetal anomalies, and infant deaths with suspected or diagnosed craniosynostosis or skull deformation. A craniofacial surgeon and a clinical geneticist reviewed 1878 medical records for diagnostic confirmation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Out of 877 craniosynostosis cases, 83% were single\u2010suture synostoses (all live births), 10% craniosynostosis syndromes, and 7% multisutural non\u2010syndromic synostoses. Live birth prevalence from 1987 to 2010 was 6.0\/10,000 live births, ranging from 5.0\/10,000 in 1987 to 7.5\/10,000 in 2010. Total prevalence, including live births, stillbirths, and terminations, varied from 5.0\/10,000 in 1987 to 8.0\/10,000 in 2010. Sagittal synostosis was the most common synostosis, with a prevalence of 3.9\/10,000 live births, followed by metopic (0.6\/10,000), unicoronal (0.4\/10,000), and unilambdoid (0.1\/10,000) synostoses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The total combined prevalence of all craniosynostosis types significantly increased driven by a nonsignificant rise across all subgroups and a significant increase in the syndrome group. In live births increase was significant only within the syndrome subgroup, primarily due to an increase in Muenke syndrome patients. The rising prevalence of syndromes necessitates further investigation. Contrasting with trends in Europe, Australia, and the USA, Finland showed no significant increase in metopic craniosynostosis.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2319","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T09:37:48Z","timestamp":1707817068000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Prevalence of craniosynostosis in Finland, 1987\u20132010: A population\u2010based study"],"prefix":"10.1002","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7403-9846","authenticated-orcid":false,"given":"Pia","family":"Vuola","sequence":"first","affiliation":[{"name":"The Cleft and Craniofacial Center, Department of Plastic Surgery Helsinki University Hospital and University of Helsinki  Helsinki 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