{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:48:16Z","timestamp":1790704096951,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T00:00:00Z","timestamp":1709596800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Situs inversus is a rare congenital condition, defined by the mirror\u2010image transposition of the abdominothoracic organs. It is linked to an increased risk of different disorders, for example, congenital heart defects and primary ciliary dyskinesia. Recently, some reports have been on the increased incidence of situs inversus after the COVID\u201019 pandemic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To investigate the association between maternal COVID\u201019 infection and fetal situs inversus occurrence risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All pregnant women who underwent fetal ultrasound examinations at Jinan Maternal and Child Health Hospital from January to May of 2022 and 2023 were recruited. A chi\u2010square test was conducted to assess the association of maternal COVID\u201019 infection with the incidence rate of fetal situs inversus.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 8381 patients, including 25 with situs inversus fetuses were recruited. A total of 3956 patients had COVID\u201019, while 4400 did not. Among 25 mothers with situs inversus fetuses, 22 had COVID\u201019 and 3 without recent infection. Our analysis showed a strong link between COVID\u201019 and a higher risk of fetus situs inversus (<jats:italic>P<\/jats:italic>\u2009&lt;\u2009.001, odds ratio 8.196).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Maternal COVID\u201019 infection in the early stages of the pregnancy is associated with an increased risk of fetal situs inversion occurrence. Therefore, further research in this field seems necessary.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2324","type":"journal-article","created":{"date-parts":[[2024,3,5]],"date-time":"2024-03-05T13:14:33Z","timestamp":1709644473000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Correlation between COVID\u201019 infection and fetal situs inversus"],"prefix":"10.1002","volume":"116","author":[{"given":"Shuo","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Ultrasound, Jinan Maternity and Child Care Hospital Shandong First Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Jinan Maternity and Child Care Hospital Shandong First Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranran","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Outpatient Jinan Youfu Hospital  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Jinan Maternity and Child Care Hospital Shandong First Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongying","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound, Jinan Maternity and Child Care Hospital Shandong First Medical University  Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,3,5]]},"reference":[{"key":"e_1_2_9_2_1","first-page":"14","article-title":"World Medical Association Declaration of Helsinki: Ethical principles for medical research involving human subjects","volume":"81","author":"Association G. 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M.","year":"2014","journal-title":"The Journal of the American College of Dentists"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1652"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJGM.S295444"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2022.834771"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13052-022-01368-6"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-020-00459-7"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.3389\/fped.2021.662165"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2021.08.054"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.2217\/fvl-2023-0089"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijantimicag.2020.105924"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0253347"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.4236\/ojim.2022.122010"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.798767"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.61810"},{"key":"e_1_2_9_16_1","first-page":"2554","article-title":"COVID\u201019 in pregnant women, maternal\u2014Fetal involvement, and vertical mother\u2010to\u2010child transmission: A systematic review","volume":"10","author":"S\u00e1nchez\u2010Garc\u00eda J. C.","year":"2022","journal-title":"Biomedicine"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-63761-3_14"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc2309215"},{"key":"e_1_2_9_19_1","volume-title":"Textbook of gastroenterology","author":"Yamada T.","year":"2011"}],"container-title":["Birth Defects Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.2324","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,3,27]],"date-time":"2024-03-27T13:34:07Z","timestamp":1711546447000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdr2.2324"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,3]]},"references-count":18,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1002\/bdr2.2324"],"URL":"https:\/\/doi.org\/10.1002\/bdr2.2324","archive":["Portico"],"relation":{},"ISSN":["2472-1727","2472-1727"],"issn-type":[{"value":"2472-1727","type":"print"},{"value":"2472-1727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,3]]},"assertion":[{"value":"2023-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-02-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-03-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2324"}}