{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T08:49:28Z","timestamp":1791362968478,"version":"4.3.1"},"reference-count":54,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100018553","name":"Science and Technology Plan Project of Wenzhou Municipality","doi-asserted-by":"publisher","award":["Y20190096"],"award-info":[{"award-number":["Y20190096"]}],"id":[{"id":"10.13039\/501100018553","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>According to reports, prenatal exposure to valproic acid can induce autism spectrum disorder (ASD)\u2010like symptoms in both humans and rodents. However, the exact cause and therapeutic method of ASD is not fully understood. Agmatine (AGM) is known for its neuroprotective effects, and this study aims to explore whether giving agmatine hydrochloride before birth can prevent autism\u2010like behaviors in mouse offspring exposed prenatally to valproic acid.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we investigated the effects of AGM prenatally on valproate (VPA)\u2010exposed mice. We established a mouse model of ASD by prenatally administering VPA. From birth to weaning, we evaluated mouse behavior using the marble burying test, open\u2010field test, and three\u2010chamber social interaction test on male offspring.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The results showed prenatal use of AGM relieved anxiety and hyperactivity behaviors as well as ameliorated sociability of VPA\u2010exposed mice in the marble burying test, open\u2010field test, and three\u2010chamber social interaction test, and this protective effect might be attributed to the activation of the ERK\/CREB\/BDNF signaling pathway.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Therefore, AGM can effectively reduce the likelihood of offspring developing autism to a certain extent when exposed to VPA during pregnancy, serving as a potential therapeutic drug.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2336","type":"journal-article","created":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T12:04:48Z","timestamp":1713269088000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["The prenatal use of agmatine prevents social behavior deficits in <scp>VPA<\/scp>\u2010exposed mice by activating the <scp>ERK<\/scp>\/<scp>CREB<\/scp>\/<scp>BDNF<\/scp> signaling pathway"],"prefix":"10.1002","volume":"116","author":[{"given":"Shihao","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Neurology the First Affiliated Hospital of Wenzhou Medical University  Wenzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Neurology the First Affiliated Hospital of Wenzhou Medical University  Wenzhou 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