{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T13:17:28Z","timestamp":1790687848934,"version":"4.1.0"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T00:00:00Z","timestamp":1716422400000},"content-version":"vor","delay-in-days":22,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>To describe and conclude the in vitro fertilization (IVF) results of patients with X chromosome abnormality.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective case series was conducted. According to the number of normal X, patients were allocated into two groups: Group A (patients with only a normal X, while other X has any types of abnormalities) and Group B (patients have two or more normal X chromosomes). Clinical data, including basic information, fertility information, and IVF outcomes, were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fourteen patients with X chromosome abnormality were included, among which 13 patients underwent a total of 29\u2009cycles. Patients in Group B had five successful pregnancies and three live births, while no patient in Group A had a clinical pregnancy. Furthermore, the blastocyst formation rate and incidence of pregnancy were significantly lower in Group A (<jats:italic>Z<\/jats:italic>\u2009=\u2009\u22123.135, <jats:italic>p<\/jats:italic>\u2009=\u2009.002; <jats:italic>Z<\/jats:italic>\u2009=\u2009\u22122.946, <jats:italic>p<\/jats:italic>\u2009=\u2009.003, respectively). When controlled covariates, the karyotype of one normal X was also a risk factor for both blastocyst formation rate and success pregnancy (<jats:italic>\u03b2<\/jats:italic>\u2009=\u2009.820, 95% confidence interval [CI] =\u20090.458\u20131.116, <jats:italic>\u03b2<\/jats:italic>\u2009=\u2009.333, 95% CI\u2009=\u20090.017\u20130.494, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our results revealed that women with only one normal X might suffer from worse IVF outcomes, mainly blastocyst formation rate, compared with those who had two or more normal X, including mosaic Turner syndrome and 47,XXX.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2349","type":"journal-article","created":{"date-parts":[[2024,5,23]],"date-time":"2024-05-23T07:14:12Z","timestamp":1716448452000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["In vitro fertilization and pregnancy outcomes of women with X chromosome abnormality: A case series"],"prefix":"10.1002","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8963-1105","authenticated-orcid":false,"given":"Ruohan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology West China Second University Hospital, Sichuan University  Chengdu Sichuan China"},{"name":"Department of Obstetrics and Gynecology, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education West China Second University Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linyu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology West China Second University Hospital, Sichuan University  Chengdu Sichuan China"},{"name":"Department of Obstetrics and Gynecology, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education West China Second University Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Liao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology West China Second University Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology West China Second University Hospital, Sichuan University  Chengdu Sichuan China"},{"name":"Department of Obstetrics and Gynecology, Center for Translational Medicine, Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education West China Second University Hospital, Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianhong","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology West China Second University Hospital, Sichuan University  Chengdu Sichuan China"},{"name":"Department of Obstetrics\/Gynecology, Key Laboratory of Obstetric, Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education West China Second University Hospital, Sichuan University  Chengdu Sichuan 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