{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:04:04Z","timestamp":1753862644442,"version":"3.41.2"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T00:00:00Z","timestamp":1728864000000},"content-version":"vor","delay-in-days":13,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To identify cardiovascular ultrasound predictors for brain anomalies in fetuses with heart disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A literature search was performed in the following databases: MEDLINE through OVID, EMBASE, Cochrane Registry Center for Controlled Trials (CENTRAL), and LILACS, from their inception until May 2023. Clinical studies, cross\u2010sectional studies, case\u2013control studies, cohorts, and systematic reviews were included. Data extraction was performed, and the risk of bias was assessed using the QUADAS\u20102 tool.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 2705 studies evaluated, after filtering information, 10 articles were selected that met the inclusion criteria. These studies noted the following outcomes: a decrease in fetal head circumference, changes in brain maturation measured in days, decreased depth of brain fissures, and a decrease in total brain volume. The studies show a statistically significant correlation with the presence of the following cardiovascular predictors: low or mixed oxygen content in the ascending aorta (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), retrograde flow in the aortic arch (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), lower <jats:italic>z<\/jats:italic> values of the MCA\u2010PI (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05), higher UA\u2010PI <jats:italic>z<\/jats:italic> values (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), and lower CPR (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). In addition, lower values of left ventricular flow (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01), ductus arteriosus (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001), and combined cardiac output index (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.01) were reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This review describes the most relevant evidence correlating the effects of hemodynamic changes that lead to states of chronic hypoxia related to the aforementioned changes in the central nervous system.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2402","type":"journal-article","created":{"date-parts":[[2024,10,14]],"date-time":"2024-10-14T11:53:36Z","timestamp":1728906816000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cardiovascular Ultrasound Predictors for Brain Alterations in Fetuses With Heart Disease: An Exploratory Review of the Literature"],"prefix":"10.1002","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2565-2676","authenticated-orcid":false,"given":"Mar\u00eda Alejandra Aguirre","family":"Mart\u00ednez","sequence":"first","affiliation":[{"name":"Resident in Obstetrics and Gynecology Universidad Libre Seccional Cali  Cali Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Luisa Fernanda Cano","family":"Bautista","sequence":"additional","affiliation":[{"name":"Resident in Obstetrics and Gynecology Universidad Libre Seccional Cali  Cali Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mauricio","family":"Hern\u00e1ndez\u2010Carrillo","sequence":"additional","affiliation":[{"name":"Statistician, Master in Epidemiology, Doctor in Health Graduate Professor Universidad Libre Seccional Cali  Cali Colombia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Armicson Felipe Solano","family":"Montero","sequence":"additional","affiliation":[{"name":"Specialist in Maternal Fetal Medicine Fundaci\u00f3n Universitaria de Ciencias de la Salud FUCS  Bogota 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