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The potential for developmental neurotoxicity (DNT) at permissible DA levels has previously been noted, but not methodically assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Studies of DNT following DA exposure in experimental and wild animals were identified through a comprehensive search strategy. Evidence from papers meeting inclusion criteria was evaluated for specific outcomes reported for doses at which adverse effects were observed. Exposure levels associated with DNT were compared with those known to cause adult toxicity. The findings are discussed in the context of the well\u2010characterized mechanism of DA neurotoxicity, as well as the toxicokinetics of DA across species and life stages.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>DNT outcomes were reported with a no observed adverse effect level (NOAEL) 10 times lower than the NOAEL of 0.75\u2009mg DA\/kg for acute effects in adults. Apart from reviewing current regulatory action levels, public health outreach messaging to health care professionals and sensitive populations, such as pregnant or breastfeeding women, should be considered as a means of increasing awareness about risk for DNT from consumption of potentially DA\u2010contaminated seafood.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2419","type":"journal-article","created":{"date-parts":[[2024,12,13]],"date-time":"2024-12-13T12:03:45Z","timestamp":1734091425000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Life Course Considerations in Environmental Health: Developmental Neurotoxicity of Domoic Acid at Doses Below Acute Effect Levels in Adult Humans"],"prefix":"10.1002","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9033-7754","authenticated-orcid":false,"given":"Marlissa A.","family":"Campbell","sequence":"first","affiliation":[{"name":"Office of Environmental 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