{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,19]],"date-time":"2026-07-19T01:52:57Z","timestamp":1784425977162,"version":"3.55.0"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T00:00:00Z","timestamp":1733961600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000030","name":"Centers for Disease Control and Prevention","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000030","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Previous studies of maternal alcohol consumption and craniosynostosis have reported null or inverse associations. We updated a previous analysis of National Birth Defects Prevention Study (NBDPS) data to further examine associations between maternal alcohol consumption and craniosynostosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>NBDPS was a multi\u2010site, population\u2010based case\u2013control study. Mothers of craniosynostosis cases and randomly selected liveborn controls delivered during 1997\u20132011 completed a telephone interview about pregnancy exposures. We examined associations for self\u2010reported periconceptional maternal alcohol consumption (during the month before conception through the third gestational month) and odds of craniosynostosis in offspring. We used logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs) for associations between any alcohol consumption and binge consumption and craniosynostosis, overall and by affected suture. Finally, we performed a probabilistic bias analysis using a range of assumptions about the sensitivity and specificity of self\u2010reported consumption by case\/control status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analyzed interview data from 1435 mothers of craniosynostosis cases and 11,216 mothers of controls. Periconceptional alcohol consumption prevalence was similar among case (36.9%) and control (38.2%) mothers. We observed point estimates near or below 1.0 for alcohol consumption (any and binge) and all suture subtypes of craniosynostosis, with all CIs including the null. Our bias\u2010adjusted estimates for periconceptional alcohol consumption were higher than our conventional estimates but supported the null findings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We observed primarily null associations between maternal periconceptional alcohol consumption and craniosynostosis. However, our findings do not diminish the prevailing clinical guidance in the United States that pregnant people should abstain from alcohol consumption.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2420","type":"journal-article","created":{"date-parts":[[2024,12,12]],"date-time":"2024-12-12T09:44:18Z","timestamp":1733996658000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Associations Between Maternal Periconceptional Alcohol Consumption and Risk of Craniosynostosis Among Offspring, National Birth Defects Prevention Study, 1997\u20132011"],"prefix":"10.1002","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4702-1007","authenticated-orcid":false,"given":"Sarah C.","family":"Fisher","sequence":"first","affiliation":[{"name":"Birth Defects Registry New York State Department of Health  Albany New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5393-9984","authenticated-orcid":false,"given":"Paul A.","family":"Romitti","sequence":"additional","affiliation":[{"name":"Department of Epidemiology College of Public Health, University of Iowa  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Tracy","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Biostatistics School of Public Health, University at Albany  Rensselaer New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8420-5040","authenticated-orcid":false,"given":"Meredith M.","family":"Howley","sequence":"additional","affiliation":[{"name":"Birth Defects Registry New York State Department of Health  Albany New York USA"},{"name":"Department of Epidemiology and Biostatistics School of Public Health, University at Albany  Rensselaer New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ethylin Wang","family":"Jabs","sequence":"additional","affiliation":[{"name":"Department of Genetics and Genomic Sciences Icahn School of Medicine at Mount Sinai  New York New York USA"},{"name":"Department of Clinical Genomics Mayo Clinic  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1872-2787","authenticated-orcid":false,"given":"Marilyn L.","family":"Browne","sequence":"additional","affiliation":[{"name":"Birth Defects Registry New York State Department of Health  Albany New York USA"},{"name":"Department of Epidemiology and Biostatistics School of Public Health, University at Albany  Rensselaer New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the National Birth Defects Prevention Study","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jobcr.2020.11.016"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/tera.1420500103"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.aje.a114983"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2008.10.109"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.32208"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdrc.21129"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36953"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20426"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1044"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23292"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20716"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwq381"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ppe.12882"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/ije\/dyi184"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm7101a2"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa0907328"},{"key":"e_1_2_10_18_1","first-page":"2863","article-title":"Craniosynostosis","volume":"69","author":"Kabbani H.","year":"2004","journal-title":"American Family Physician"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1597\/04-031.1"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9926(199909)60:3<146::AID-TERA10>3.0.CO;2-3"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/pr.2012.36"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.2001.95.5.0778"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2393-14-127"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e318252d893"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1656"},{"key":"e_1_2_10_26_1","first-page":"79","article-title":"Cotinine Validation of Self\u2010Reported Smoking During Pregnancy in the Swedish Medical Birth Register","volume":"18","author":"Mattsson K.","year":"2016","journal-title":"Nicotine & Tobacco Research"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.a.36865"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.10012"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23384"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deq313"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.111.S1.1163"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20823"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1093\/aje\/kwm146"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1824"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.annepidem.2013.12.008"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000004997"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-8628(19990423)83:5<382::AID-AJMG8>3.0.CO;2-A"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1097\/GOX.0000000000005013"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1542\/peds.2013-3118"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.mm6437a3"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20529"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1097\/00001665-200209000-00002"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.23352"}],"container-title":["Birth Defects Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.2420","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T04:08:20Z","timestamp":1735358900000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdr2.2420"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":42,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2024,12]]}},"alternative-id":["10.1002\/bdr2.2420"],"URL":"https:\/\/doi.org\/10.1002\/bdr2.2420","archive":["Portico"],"relation":{},"ISSN":["2472-1727","2472-1727"],"issn-type":[{"value":"2472-1727","type":"print"},{"value":"2472-1727","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"2024-08-02","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-11-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-12-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2420"}}