{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,25]],"date-time":"2026-04-25T09:15:49Z","timestamp":1777108549165,"version":"3.51.4"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T00:00:00Z","timestamp":1734566400000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2024,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Agnathia\u2010otocephaly complex (AOC) is a rare and complex craniofacial malformation characterized by mandibular hypoplasia or agnathia, auricular fusion, microstomia with oroglossal hypoplasia or aglossia. It has a very bad prognosis and can arise alone or in conjunction with heart defects and forebrain abnormalities.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case Report<\/jats:title><jats:p>A standard second\u2010trimester ultrasound exam was recommended for, a 23\u2010year\u2010old primigravida woman who was at 22\u2009weeks gestation. The oral fissure was \u201cpinhole\u2010shaped,\u201d the mouth was incredibly small, and the usual lower jaw and lower lip had vanished from the S\u2010curve. On the front of the neck were the two ears. Amniocentesis revealed a 46,XY normal karyotype. The family opted for a medically assisted termination. At 23\u2009weeks, the pregnancy was ended by vaginal delivery. Observation of the specimen revealed that the ear placements were remarkably low, and the specimen's observation revealed that the two earlobes were joined at the front of the neck.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Identifying the development of the mandible and locating auricles during prenatal ultrasound diagnosis was particularly challenging could be a better way to phrase this like in our recent example, the combination of two\u2010dimensional and three\u2010dimensional ultrasound was able to confirm the prenatal diagnosis of AOC.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2421","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T08:49:49Z","timestamp":1734598189000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Otocephaly Diagnosed Prenatally: A Case Study of a Rare Congenital Defect"],"prefix":"10.1002","volume":"116","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2235-4961","authenticated-orcid":false,"given":"Birsen","family":"Konukcu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Perinatology un\u0131t of Elaz\u0131\u011f City Hospital  Elaz\u0131\u011f Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"Brecht K. andC. 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