{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T11:13:35Z","timestamp":1781867615974,"version":"3.54.5"},"reference-count":37,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T00:00:00Z","timestamp":1739836800000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Anorectal malformations are birth defects that affect 1 in 5000 live births. Despite the research, the cause is still unknown, but genetic and environmental factors have been described to contribute to its pathogenesis. We report the case of a child with an anterior ectopic anus in which prenatal environmental factors were systematically assessed using a screening evaluation interview, the Green Page, and a complete Pediatric Environmental History.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>A first born of a 29\u2009year old woman with a history of epilepsy treated with high doses of lamotrigine, levetiracetam, and clobazam, and a subclinical hypothyroidism treated with levothyroxine. Periconceptional supplementation with 400mcg of folic acid, maternal and paternal smoking habit, and some occupational exposures to chemical hazards. No personal or family history of congenital malformations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>Some previously related environmental factors were found, such as mother's epilepsy, high lamotrigine dose, tobacco exposure, air pollution, and in a lesser risk the use of levothyroxine. The Green Page and the Pediatric Environmental History could contribute to identifying and reducing environmental risks related to birth defects.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2445","type":"journal-article","created":{"date-parts":[[2025,2,18]],"date-time":"2025-02-18T14:00:49Z","timestamp":1739887249000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Assessing Environmental Risks Factors in Anorectal Malformations: Case Report and Literature Review"],"prefix":"10.1002","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0009-0000-0512-7156","authenticated-orcid":false,"given":"Claudia","family":"Ortiz\u2010Fernandez","sequence":"first","affiliation":[{"name":"Department of Pediatrics Hospital Adriana Cousi\u00f1o de Quintero  Valpara\u00edso Chile"},{"name":"Children's Environmental Health Committee Chilean Society of Pediatrics (SOCHIPE)  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0903-4499","authenticated-orcid":false,"given":"Ferran","family":"Campillo i L\u00f3pez","sequence":"additional","affiliation":[{"name":"Pediatric Environmental Health Specialty Unit (PEHSU), Garrotxa Regional Pediatric Team Olot and Garrotxa Regional Hospital Foundation  Olot Spain"},{"name":"Environmental Health Committee, Spanish Association of Pediatrics  Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9774-9020","authenticated-orcid":false,"given":"Stephan Otto","family":"Schneider","sequence":"additional","affiliation":[{"name":"Pediatric Gastroenterology, Garrotxa Regional Pediatric Team Olot and Garrotxa Regional Hospital Foundation  Olot Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7790-2166","authenticated-orcid":false,"given":"Bernardo","family":"N\u00fa\u00f1ez","sequence":"additional","affiliation":[{"name":"Pediatric Surgery, Hospital de Sabadell Consorci Corporaci\u00f3 Sanit\u00e0ria Parc Taul\u00ed  Sabadell Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4696-2312","authenticated-orcid":false,"given":"Anton Foguet i","family":"Vidal","sequence":"additional","affiliation":[{"name":"Pediatric Environmental Health Specialty Unit (PEHSU), Garrotxa Regional Pediatric Team Olot and Garrotxa Regional Hospital Foundation  Olot Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,2,18]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/s22165994"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdra.20573"},{"key":"e_1_2_5_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ohx.2019.e00070"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.25100\/cm.v52i3.4227"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000207996"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpediatrics.2009.188"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1136\/oem.2009.048256"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.15761\/PD.1000109"},{"key":"e_1_2_5_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tox.2015.10.006"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/160780"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pedneo.2020.09.008"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X19666210211150856"},{"key":"e_1_2_5_14_1","doi-asserted-by":"publisher","DOI":"10.2185\/jrm.2872"},{"key":"e_1_2_5_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sempedsurg.2022.151226"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijheh.2007.07.008"},{"key":"e_1_2_5_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anpedi.2009.10.016"},{"key":"e_1_2_5_18_1","volume-title":"Manual de la Hoja Verde de Salud Medioambiental Reproductiva","author":"Ortega\u2010Garc\u00eda J. 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