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Echinochrome (Ech) is the most common dark red pigment of sea urchin shells and possesses high antioxidant and hypoglycemic properties. Quercetin (Quer) is a flavonol widely distributed in plants with high antioxidant properties. Therefore, Ech and Quer as a combined protective therapy were investigated against letrozole and high\u2010fat diet\u2010induced PCOS model in rats.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty female rats were divided randomly into five groups: Control: received 2% DMSO with a normal diet, PCOS: received letrozole with HFD, Ech: received letrozole and Ech with HFD, Quer: received letrozole and Quer with HFD, Ech\u2009+\u2009Quer: received letrozole, Ech, and Quer together daily orally for 4\u2009weeks. Half of the rats in each group were sacrificed, and the remaining rats were examined for their ability to mate and fertility.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Ech and Quer treatment restored normal levels of lipid and hormonal profiles, oxidative status, kidney and liver functions with a marked amelioration in ovarian, uterine histopathology, and a good evidence in pregnancy analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Ech and Quer were found to have a potent protective effect against PCOS, minimal side effects, and improved progeny outcomes in rats.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2487","type":"journal-article","created":{"date-parts":[[2025,5,21]],"date-time":"2025-05-21T04:39:43Z","timestamp":1747802383000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Protective Impacts of Quercetin and Echinochrome on Female Fertility and Pregnancy Outcomes in Polycystic Ovary Syndrome in Rats"],"prefix":"10.1002","volume":"117","author":[{"given":"Rokia Gamal","family":"Mohamed","sequence":"first","affiliation":[{"name":"Zoology Department, Faculty of Science Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ayman Saber","family":"Mohamed","sequence":"additional","affiliation":[{"name":"Zoology Department, Faculty of Science Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed Imam","family":"Dakrory","sequence":"additional","affiliation":[{"name":"Zoology Department, Faculty of Science Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mennatallah H.","family":"Abdelaziz","sequence":"additional","affiliation":[{"name":"Zoology Department, Faculty of Science Cairo University  Giza Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.2131"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/bdr2.1535"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00404-020-05951-2"},{"issue":"4","key":"e_1_2_10_5_1","first-page":"651","article-title":"Protective Effects of Thymoquinone on Doxorubicin\u2010Induced Lipid Peroxidation and Antioxidant Enzyme Levels in Rat Peripheral Tissues","volume":"43","author":"Akpinar D.","year":"2023","journal-title":"Pakistan Veterinary Journal"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjbs.2021.06.066"},{"issue":"1","key":"e_1_2_10_7_1","first-page":"8","article-title":"Protective Role of Endothelial Nitric Oxide Synthase","volume":"199","author":"Albrecht E. 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