{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T01:59:46Z","timestamp":1755223186091,"version":"3.43.0"},"reference-count":37,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Birth Defects Research"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Maternal vaccines are upcoming. A clear picture of the adverse events (AEs) after maternal vaccination and whether this is comparable to a nonpregnant population is important. The objective of our study was to compare perceived AEs after COVID\u201019 vaccination between pregnant and nonpregnant women and to study if it is feasible to compare AEs within two independent Dutch cohort studies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data from the Dutch Pregnancy Drug Register (DPDR) and the cohort event monitoring (CEM) study on COVID\u201019 vaccines were used. At least one self\u2010reported (solicited) AE, more than one AE, and specific self\u2010reported AEs after the first doses of an mRNA COVID\u201019 vaccine were compared between pregnant and nonpregnant women using multivariable logistic regression analysis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The pattern of AEs was similar between pregnant (<jats:italic>n<\/jats:italic>\u2009=\u20092204) and nonpregnant (<jats:italic>n<\/jats:italic>\u2009=\u20092684) women, with the four most frequently reported AEs being: injection site reaction, myalgia, fatigue, and headache. Pregnant women reported less often at least one AE compared to nonpregnant women (65.9% vs. 72.3%; adjusted odds ratio [aOR]\u2009=\u20090.78; 95% confidence interval [CI]\u2009=\u20090.67\u20130.90), more than one AE, or specific AEs: nausea, chills, pyrexia, and arthralgia. Myalgia was more often reported among pregnant women compared to nonpregnant women.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Pregnant women perceived comparable or less often AEs after the first mRNA COVID\u201019 vaccination compared to nonpregnant women. The results aid pregnant women in making an informed decision about vaccination. A comparison between the pregnancy registry and the CEM study was feasible and this method can be used to compare AEs for other\/future maternal vaccines.<\/jats:p><\/jats:sec>","DOI":"10.1002\/bdr2.2490","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T06:13:39Z","timestamp":1749190419000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Comparison of Perceived Adverse Events After <scp>COVID<\/scp>\u201019 Vaccination Between Pregnant and NonPregnant Women Using Two Cohort Studies in the Netherlands"],"prefix":"10.1002","volume":"117","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1010-7373","authenticated-orcid":false,"given":"Petra J.","family":"Woestenberg","sequence":"first","affiliation":[{"name":"Netherlands Pharmacovigilance Centre Lareb  's\u2010Hertogenbosch the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika W.","family":"Terpstra","sequence":"additional","affiliation":[{"name":"Netherlands Pharmacovigilance Centre Lareb  's\u2010Hertogenbosch the Netherlands"},{"name":"Faculty of Medical Sciences, Radboudumc Radboud University  Nijmegen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Florence","family":"van Hunsel","sequence":"additional","affiliation":[{"name":"Netherlands Pharmacovigilance Centre Lareb  's\u2010Hertogenbosch the Netherlands"},{"name":"Groningen Research Institute of Pharmacy, PharmacoTherapy, \u2010Epidemiology and Economics University of Groningen  Groningen the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Lieber","sequence":"additional","affiliation":[{"name":"Netherlands Pharmacovigilance Centre Lareb  's\u2010Hertogenbosch the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2925-8174","authenticated-orcid":false,"given":"Veronique Y. F.","family":"Maas","sequence":"additional","affiliation":[{"name":"Netherlands Pharmacovigilance Centre Lareb  's\u2010Hertogenbosch the Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1016\/j.ajog.2024.02.008"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.1002\/uog.23729"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.1055\/s\u20100042\u20101748158"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.1016\/j.lanepe.2024.101069"},{"doi-asserted-by":"publisher","key":"e_1_2_10_6_1","DOI":"10.1016\/j.ejogrb.2020.10.035"},{"doi-asserted-by":"publisher","key":"e_1_2_10_7_1","DOI":"10.3389\/fimmu.2020.572567"},{"doi-asserted-by":"publisher","key":"e_1_2_10_8_1","DOI":"10.1136\/bmjgh\u20102023\u2010012376"},{"doi-asserted-by":"publisher","key":"e_1_2_10_9_1","DOI":"10.1002\/pds.5724"},{"doi-asserted-by":"publisher","key":"e_1_2_10_10_1","DOI":"10.3389\/fdsfr.2023.1235051"},{"key":"e_1_2_10_11_1","first-page":"D7850","article-title":"From This Autumn, Influenza Vaccination for All Pregnant Women","volume":"167","author":"Duvekot J. J.","year":"2023","journal-title":"Nederlands Tijdschrift voor Geneeskunde"},{"doi-asserted-by":"publisher","key":"e_1_2_10_12_1","DOI":"10.1016\/j.ajog.2021.10.041"},{"doi-asserted-by":"publisher","key":"e_1_2_10_13_1","DOI":"10.1002\/bdr2.1696"},{"doi-asserted-by":"publisher","key":"e_1_2_10_14_1","DOI":"10.1016\/j.ajog.2021.03.023"},{"doi-asserted-by":"publisher","key":"e_1_2_10_15_1","DOI":"10.4161\/hv.29610"},{"doi-asserted-by":"publisher","key":"e_1_2_10_16_1","DOI":"10.1001\/jamanetworkopen.2022.30495"},{"doi-asserted-by":"publisher","key":"e_1_2_10_17_1","DOI":"10.1001\/jamanetworkopen.2021.21310"},{"doi-asserted-by":"publisher","key":"e_1_2_10_18_1","DOI":"10.1016\/j.ajog.2021.06.007"},{"doi-asserted-by":"publisher","key":"e_1_2_10_19_1","DOI":"10.1007\/s40264\u2010022\u201001151\u2010w"},{"doi-asserted-by":"publisher","key":"e_1_2_10_20_1","DOI":"10.1055\/a\u20101745\u20101168"},{"doi-asserted-by":"publisher","key":"e_1_2_10_21_1","DOI":"10.1038\/s41467\u2010022\u201030052\u2010w"},{"doi-asserted-by":"publisher","key":"e_1_2_10_22_1","DOI":"10.1016\/j.vaccine.2024.03.001"},{"doi-asserted-by":"publisher","key":"e_1_2_10_23_1","DOI":"10.1007\/s40264\u2010023\u201001281\u20109"},{"doi-asserted-by":"publisher","key":"e_1_2_10_24_1","DOI":"10.1371\/journal.pone.0298407"},{"doi-asserted-by":"publisher","key":"e_1_2_10_25_1","DOI":"10.1097\/GRF.0000000000000882"},{"doi-asserted-by":"publisher","key":"e_1_2_10_26_1","DOI":"10.1016\/j.vaccine.2022.01.013"},{"doi-asserted-by":"publisher","key":"e_1_2_10_27_1","DOI":"10.1056\/NEJMoa2104983"},{"doi-asserted-by":"publisher","key":"e_1_2_10_28_1","DOI":"10.1055\/s\u20100040\u20101712103"},{"doi-asserted-by":"publisher","key":"e_1_2_10_29_1","DOI":"10.1136\/bmjgh\u20102022\u2010009495"},{"doi-asserted-by":"publisher","key":"e_1_2_10_30_1","DOI":"10.1007\/s40121\u2010019\u201000264\u20107"},{"doi-asserted-by":"publisher","key":"e_1_2_10_31_1","DOI":"10.1111\/joim.12159"},{"doi-asserted-by":"publisher","key":"e_1_2_10_32_1","DOI":"10.18637\/jss.v045.i03"},{"doi-asserted-by":"publisher","key":"e_1_2_10_33_1","DOI":"10.1016\/S0140\u20106736(22)02467\u20109"},{"doi-asserted-by":"publisher","key":"e_1_2_10_34_1","DOI":"10.1007\/s40264\u2010018\u20100722\u20107"},{"doi-asserted-by":"publisher","key":"e_1_2_10_35_1","DOI":"10.2165\/00002018\u2010200528110\u201000006"},{"doi-asserted-by":"publisher","key":"e_1_2_10_36_1","DOI":"10.1002\/bdr2.2251"},{"key":"e_1_2_10_37_1","first-page":"D6831","article-title":"Self\u2010Reported Maternal Adverse Events of Covid\u201019 Vaccination During Pregnancy","volume":"166","author":"Woestenberg P. J.","year":"2022","journal-title":"Nederlands Tijdschrift voor Geneeskunde"},{"doi-asserted-by":"publisher","key":"e_1_2_10_38_1","DOI":"10.1002\/ped4.12456"}],"container-title":["Birth Defects Research"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/bdr2.2490","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,11]],"date-time":"2025-08-11T12:51:55Z","timestamp":1754916715000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/bdr2.2490"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":37,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/bdr2.2490"],"URL":"https:\/\/doi.org\/10.1002\/bdr2.2490","archive":["Portico"],"relation":{},"ISSN":["2472-1727","2472-1727"],"issn-type":[{"type":"print","value":"2472-1727"},{"type":"electronic","value":"2472-1727"}],"subject":[],"published":{"date-parts":[[2025,6]]},"assertion":[{"value":"2024-11-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-05","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-06","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e2490"}}